<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated concentrations of arsenic mainly via drinking water. Essential trace elements can affect toxicity of metals by interacting with metals at the primary site of action and can also modify the body's response to toxic metals by altering their metabolism and transport. This study investigates the effects of concomitant administration of selenium, magnesium, and calcium with arsenic on blood biochemistry and oxidative stress. Selenium was the most effective in reducing arsenic-induced inhibition of blood δ-aminolevulinic acid dehydratase (ALAD) activity and liver oxidative stress. Calcium and magnesium also showed favourable effects on haematological and other biochemical parameters. Because selenium was the most effective, it should be added to chelation therapy to achieve the best protective effects against arsenic poisoning in humans.</p></abstract>

Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated concentrations of arsenic mainly via drinking water. Essential trace elements can affect toxicity of metals by interacting with metals at the primary site of action and can also modify the body's response to toxic metals by altering their metabolism and transport. This study investigates the effects of concomitant administration of selenium, magnesium, and calcium with arsenic on blood biochemistry and oxidative stress. Selenium was the most effective in reducing arsenic-induced inhibition of blood δ-aminolevulinic acid dehydratase (ALAD) activity and liver oxidative stress. Calcium and magnesium also showed favourable effects on haematological and other biochemical parameters. Because selenium was the most effective, it should be added to chelation therapy to achieve the best protective effects against arsenic poisoning in humans.

Protective Effects of Selenium, Calcium, and Magnesium Against Arsenic-Induced Oxidative Stress in Male Rats

Brd School of Biosciences, Sardar Patel University, Vallabh Vidyanagar

Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India

Archives of Industrial Hygiene and Toxicology

Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated...

Protective Effects of Selenium, Calcium, and Magnesium Against Arsenic-Induced Oxidative Stress in Male Rats

Published Online: Jun 25, 2010

Page range: 153 - 159

DOI: https://doi.org/10.2478/10004-1254-61-2010-1993

Keywords
ALAD, elementi u tragovima, GSH, ROS, TBARS

This content is open access.

Protective Effects of Selenium, Calcium, and Magnesium Against Arsenic-Induced Oxidative Stress in Male Rats

Published Online: Jun 25, 2010

Page range: 153 - 159

DOI: https://doi.org/10.2478/10004-1254-61-2010-1993

KeywordsALAD, elementi u tragovima, GSH, ROS, TBARS

This content is open access.

Keywords
ALAD, elementi u tragovima, GSH, ROS, TBARS