<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Prometryne is a methylthio-<italic>s</italic>-triazine herbicide. Significant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg<sup>-1</sup>) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne kinetics was similar to that reported for the structurally related herbicide atrazine.</p></abstract>

Prometryne is a methylthio-s-triazine herbicide. Significant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg-1) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne kinetics was similar to that reported for the structurally related herbicide atrazine.

Brain Toxicokinetics of Prometryne in Mice

Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia

Forensic Centre Ivan Vučetić, Ministry of Interior, Zagreb, Croatia

University Hospital for Tumours, Zagreb, Croatia

College of Applied Health Studies, Zagreb, Croatia

Archives of Industrial Hygiene and Toxicology

{"article-title":"Brain Toxicokinetics of Prometryne in Mice"}

Prometryne is a methylthio-s-triazine herbicide. Significant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of...

Brain Toxicokinetics of Prometryne in Mice

Published Online: Mar 25, 2010

Page range: 19 - 27

DOI: https://doi.org/10.2478/10004-1254-61-2010-1986

Keywords
herbicidi, krv, otrovnost, triazini, živčani sustav

This content is open access.

Brain Toxicokinetics of Prometryne in Mice

Published Online: Mar 25, 2010

Page range: 19 - 27

DOI: https://doi.org/10.2478/10004-1254-61-2010-1986

Keywordsherbicidi, krv, otrovnost, triazini, živčani sustav

This content is open access.

Keywords
herbicidi, krv, otrovnost, triazini, živčani sustav