Open Access

Comet Assay in Evaluating DNA Damage Associated With Ischaemia-Reperfusion Injury in Patients Undergoing Coronary Surgery

Taskıran A, Eskiocak S, Ege T, Duran E, Gülen S. Koroner bypass operasyonunda miyokard doku hasarının ve oksidan stresin araştırılması [Investigation of myocardial tissue injury and oxidant stress during coronary bypass, in Turk]. Turk J Biochem 2004;29:193-8.Search in Google Scholar

Ozer MK, Parlakpınar H, Acet A. Reduction of ischemia-reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE). Clin Biochem 2004;37:702-5.10.1016/j.clinbiochem.2004.01.012Search in Google Scholar

Piper HM, Meuter K, Schäfer C. Cellular mechanisms of ischemia-reperfusion injury. Ann Thorac Surg 2003;75: S644-8.10.1016/S0003-4975(02)04686-6Search in Google Scholar

Collard CD, Gelman S. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology 2001;94:1133-8.10.1097/00000542-200106000-00030Search in Google Scholar

Cordis GA, Maulik G, Bagchi D, Riedel W, Das DK. Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8-hydroxydeoxyguanosine formation. J Mol Cell Cardiol 1998;30:1939-44.10.1006/jmcc.1998.0752Search in Google Scholar

Giovannelli L, Cozzi A, Guarnieri I, Dolara P, Moroni F. Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. J Cereb Blood Flow Metab 2002;22:697-704.10.1097/00004647-200206000-00008Search in Google Scholar

Hauser B, Gröger M, Ehrmann U, Albicini M, Brückner UB, Schelzig H, Venkatesh B, Li H, Szabó C, Speit G, Radermacher P, Kick J. The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induce breakage ischemia/reperfusion. Shock 2006;25:633-40.10.1097/01.shk.0000209561.61951.2eSearch in Google Scholar

Alleva R, Tomasetti M, Solenghi MD, Stagni F, Gamberini F, Bassi A, Fornasari PM, Fanelli G, Borghi B. Lymphocyte DNA damage precedes DNA repair or cell death after orthopaedic surgery under general anaesthesia. Mutagenesis 2003;18:423-8.10.1093/mutage/geg013Search in Google Scholar

Karabiyik L, Sardaş S, Polat U, Kocaba S NA, Karakaya AE. Comparison of genotoxicity of sevoflurane and isoflurane in human lymphocytes studied in vivo using the comet assay. Mutat Res 2001;492:99-107.10.1016/S1383-5718(01)00159-0Search in Google Scholar

Oshida K, Iwanaga E, Miyamoto-Kuramitsu K, Miyamoto YJ. An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry. J Toxicol Sci 2008;33:515-24.10.2131/jts.33.51519043273Search in Google Scholar

Pincheira J, Carrera P, Marcelain K, De La Torre C. Hepatocytes, rather than leukocytes reverse DNA damage in vivo induced by whole body gamma- irradiation of mice, as shown by the alkaline comet assay. Biol Res 2008;41:217-25.10.4067/S0716-97602008000200011Search in Google Scholar

Collins A. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004;26:249-61.10.1385/MB:26:3:249Search in Google Scholar

Favreau F, Petit-Paris I, Hauet T, Dutheil D, Papet Y, Mauco G, Tallineau C. Cyclooxygenase 1-dependent production of F2-isoprostane and changes in redox status during warm renal ischemia-reperfusion. Free Rad Biol Med 2004;36:1034-42.10.1016/j.freeradbiomed.2004.01.010Search in Google Scholar

Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, Chen Z. Similarities between ozone oxidative preconditioning and ischemic preconditioning in renal ischemia/reperfusion injury. Arch Med Res 2008;39:169-78.10.1016/j.arcmed.2007.09.005Search in Google Scholar

Maulik G, Cordis GA, Das DK. Oxidative damage to myocardial proteins and DNA during ischemia and reperfusion. Ann NY Acad Sci 1996;793:431-6.10.1111/j.1749-6632.1996.tb33536.xSearch in Google Scholar

Tobita M, Nagano I, Nakamura S, Itoyama Y, Kogure K. DNA single-strand breaks in postischemic gerbil brain detected by in situ nick translation procedure. Neurosci Lett 1995;200:129-32.10.1016/0304-3940(95)12097-NSearch in Google Scholar

Chen J, Jin K, Chen M, Pei W, Kawaguchi K, Greenberg DA, Simon RP. Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death. J Neurochem 1997;69:232-45.10.1046/j.1471-4159.1997.69010232.xSearch in Google Scholar

Loft S, Larsen PN, Rasmussen A, Fischer NA, Bondesen S, Kirkegaard P, Rasmussen LS, Ejlersen E, Tornøe K, Bergholdt R. Oxidative DNA damage after transplantation of the liver and small intestine in pigs. Transplantation 1995;59:16-20.10.1097/00007890-199501150-00004Search in Google Scholar

Izdes S, Sepici-Dincel A, Gozdemir M, Ozkan Y, Kanbak O. The effect of general and regional anesthesia on ischemia-reperfusion injury. Anaesth Intensive Care 2007;35:451-2.Search in Google Scholar

Szyfter K, Szulc R, Mikstacki A, Stachecki I, Rydzanicz M, Jałoszyński P. Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo. J Appl Gen 2004;45:369-74.Search in Google Scholar

Reitz M, Antonini-Rumpf E, Lanz E. DNA single strand breaks in peripheral human lymphocytes after anesthesia with isoflurane-nitrous oxide-oxygen. Arzneimittelforschung 1993;3:1258-61.Search in Google Scholar

Sardaş S, Karabiyik L, Aygün N, Karakaya AE. DNA damage evaluated by the alkaline comet assay in lymphocytes of humans anaesthetized with isoflurane. Mutat Res 1998;418:1-6.10.1016/S1383-5718(98)00099-0Search in Google Scholar

Nagayoshi N, Kawano H, Hokamaki J, Miyamoto S, Kojima S, Shimomura H, Tsujita K, Sakamoto T, Yoshimura M, Ogawa H. Urinary 8-hydroxy-2'-deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events. Am J Cardiol 2005;95:514-7.10.1016/j.amjcard.2004.09.062Search in Google Scholar

Willy C, Dahouk S, Starck C, Kaffenberger W, Gerngrob H, Plappert UG. DNA damage in human leukocytes after ischemia/reperfusion injury. Free Rad Biol Med 2000;28:1-12.10.1016/S0891-5849(99)00211-7Search in Google Scholar

Vogt AM, Ackermann C, Yildiz M, Schoels W, Kübler W. Lactate accumulation rather than ATP depletion predicts ischemic myocardial necrosis: implications for the development of lethal myocardial injury. Biochim Biophys Acta 2002;1586:219-26.10.1016/S0925-4439(01)00100-4Search in Google Scholar

Gladden LB. Lactate metabolism: a new paradigm for the third millennium. J Physiol 2004;558:5-30.10.1113/jphysiol.2003.058701166492015131240Search in Google Scholar

Gal J, Riedel B, Kertai MD, Jancso G, Acsady G, Royston D, Roth E. Effects of fructose-1,6-diphosphate on endo- and myocardial purine metabolism during coronary artery bypass grafting surgery. J Cardiovasc Surg 2007 48:751-6.Search in Google Scholar

Guth BD, Wisneski JA, Neese RA, White FC, Heusch G, Mazer CD, Gertz EW. Myocardial lactate release during ischemia in swine. Relation to regional blood flow. Circulation 1990;81:1948-58.10.1161/01.CIR.81.6.1948Search in Google Scholar

ISSN:
0004-1254
Languages:
English, Slovenian
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Basic Medical Science, other