Cytotoxicity of Polyphenolic/Flavonoid Compounds in a Leukaemia Cell Culture

Oršolić N, Bašić I. Cancer chemoprevention by propolis and its polyphenolic compounds in experimental animals. In: Singh VK, Govil JN, Arunachalam C, editors. Recent Progress in Medicinal Plants. Phytochemistry and Pharmacology III. Vol. 17. Raleigh (NC): Sci Tech Publ Inc.; 2007. p. 55-114.Search in Google Scholar

Kosalec I, Sanković K, Zovko M, Oršolić N, Bakmaz M, Kalođera Z, Pepeljnjak S. Antimicrobial and antioxidant activity of propolis from Croatia and Brazil: a comparative study. Scientific evidence of the use of propolis in ehtnomedicine. In: Oršolić N, Bašić I, editors. Ethnopharmacology. Trivandrum: Research Signpost; (in press).Search in Google Scholar

Virgili F, Acconcia F, Ambra R, Rinna A, Totta P, Marino M. Nutritional flavonoids modulate estrogen receptor α signaling. IUBMB Life 2004;56:145-51.10.1080/15216540410001685083Search in Google Scholar

Oršolić N, Horvat-Knežević A, Benković V, Bašić I. Benefits of use of propolis and related flavonoids against the toxicity of chemotherapeutic agents. Scientific evidence of the use of propolis in ethnomedicine In: Oršolić N, Bašić I, editors. Ethnopharmacology. Trivandrum: Research Signpost; (in press).Search in Google Scholar

Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 2002;96:67-202.10.1016/S0163-7258(02)00298-XSearch in Google Scholar

de Vries JH, Janssen PL, Hollman PC, van Staveren WA, Katan MB. Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets. Cancer Lett 1997;114:141-4.10.1016/S0304-3835(97)04645-4Search in Google Scholar

Kim JH, Yu J, Mahoney N, Chan KL, Molyneux RJ, Varga J, Bhatnagar D, Cleveland TE, Nierman WC, Campbell BC. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. Int J Food Microbiol 2008;122:49-60.10.1016/j.ijfoodmicro.2007.11.05818166238Search in Google Scholar

Hirose M, Takesada Y, Tanaka H, Tamano S, Kato T, Shirai T. Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4- methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi- organ carcinogenesis model. Carcinogenesis 1998;19:207-12.10.1093/carcin/19.1.2079472713Search in Google Scholar

Oršolić N, Šver L, Terzić S, Tadić Z, Bašić I. Inhibitory effect of water-soluble derivative of propolis (WSDP) and its polyphenolic compounds on tumor growth and metastasing ability: A possible mode of antitumor action. Nutr Cancer 2003;47:156-63.10.1207/s15327914nc4702_815087268Search in Google Scholar

Orban Z, Mitsiades N, Burke TR, Tsokos M, Chrousos GP. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor - kappa B and suppresses acute inflammation. Neuroimmunomodulation 2000;7:99-105.10.1159/00002642710686520Search in Google Scholar

Staniforth V, Chiu LT, Yang NS. Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse. Carcinogenesis 2006;27:1803-11.10.1093/carcin/bgl00616524889Search in Google Scholar

Kellis JT Jr, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science 1984;225:1032-4.10.1126/science.64741636474163Search in Google Scholar

Oršolić N, Štajcar D, Bašić I. Cytotoxicity of propolis and its polyphenolic compounds on primary culture of human urinary bladder transitional cell carcinoma. Pharmacologyonline 2006;3: 408-15.Search in Google Scholar

Edwards DJ, Bernier SM. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Life Sci 1996;59:1025-30.Search in Google Scholar

Hsiao YC, Kuo WH, Chen PN, Chang HR, Lin TH, Yang WE, Hsieh YS, Chu SC. Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact 2007;167:193-206.10.1016/j.cbi.2007.02.01217376416Search in Google Scholar

Ho PC, Saville DJ, Coville PF, Wanwimorluk S. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv 2000;74:379-85.10.1016/S0031-6865(99)00062-XSearch in Google Scholar

Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983 65:55-63.10.1016/0022-1759(83)90303-4Search in Google Scholar

Plochmann K, Korte G, Koutsilieri E, Richling E, Riederer P, Rethwilm A, Schreier P, Scheller C. Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells. Arch Biochem Biophys 2007;460:1-9.10.1016/j.abb.2007.02.003Search in Google Scholar

Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QP. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol 2005;69:1421-32.10.1016/j.bcp.2005.02.022Search in Google Scholar

Yoshida M, Yamamoto M, Nikaido T. Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res 1992;52:6676-81.Search in Google Scholar

Liesveld J, Harbol A, Rosell K, Smith A, Abboud C. Effects of anti-oxidants on normal and leukemic hematopoiesis. Exp Hematol 2000;28:126.10.1016/S0301-472X(00)00477-XSearch in Google Scholar

Kim OH, Lee TJ, Kim YH, Lim JH, Kim S, Park JW, Kwon TK. Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells. Cancer Lett 2006;240:234-42.10.1016/j.canlet.2005.09.01316274926Search in Google Scholar

Park JB. Flavonoids are potential inhibitors of glucose uptake in U937 cells. Biochem Biophys Res Commun 1999;260:568-74.10.1006/bbrc.1999.089010403807Search in Google Scholar

Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 2007;18:427-42.10.1016/j.jnutbio.2006.11.00417321735Search in Google Scholar

Kanno S, Tomizawa A, Ohtake T, Koiwai K, Ujibe M, Ishikawa M. Naringenin-induced apoptosis via activation of NF-kB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells. Toxicol Lett 2006;166:131-9.10.1016/j.toxlet.2006.06.00516860949Search in Google Scholar

Chiao C, Carothers AM, Grunberger D, Solomon G, Preston AG, Barrett CJ. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res 1995;55:3576-83.Search in Google Scholar

Lee FYF, Siemann DW, Sutherland RM. Changes in cellular gluthatione content during adriamycin treatment in human ovarian cancer-possible indicator of chemosensitivity. Br J Cancer 1989;60:291-8.10.1038/bjc.1989.27322471862789934Search in Google Scholar

Meister A. Glutathione, ascorbate, and cellular protection. Cancer Res 1994;54:1969-75.Search in Google Scholar

Mayer M, Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trohic factor - mediated cell survival in vitro. Proc Natl Acad Sci USA 1994;91:7496-500.10.1073/pnas.91.16.7496Search in Google Scholar

Burdon R, Gill V. Cellular generated active oxygen species and HeLa cell proliferation. Free Radical Res Commun 1993;19: 203-213.10.3109/10715769309111603Search in Google Scholar

Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988;85:6465-7.10.1073/pnas.85.17.6465Search in Google Scholar

Burton RH. Supeoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radical Biol Med 1995;18:775-94.10.1016/0891-5849(94)00198-SSearch in Google Scholar

Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994;15:7-10.10.1016/0167-5699(94)90018-3Search in Google Scholar

Kass GEN, Duddy SK, Orrenius S. Activation of hepatocyte protein kinase C by redox - cycling quinones. Biochem J 1989;260:499-507.10.1042/bj2600499Search in Google Scholar

Cerutti PA, Trump BF. Inflammation and oxidative stress in carcinogenesis. Cancer Cells 1991;3:1-7.Search in Google Scholar

McConkey DJ, Hartzell P, Nicotera P, Orrenius S. Calcium - activated DNA fragmentation kills immature thymocytes. FASEB J 1989;3:1843-9.10.1096/fasebj.3.7.2497041Search in Google Scholar

Powis G. Signaling targets for anticancer drug development. Trends Pharmacol Sci 1991;12:188-94.10.1016/0165-6147(91)90545-4Search in Google Scholar

Zimmerman RJ, Marafino BJ, Chan A, Landre P, Winkelhake JL. The role of oxidant injury in tumor cell sensitivity to recombinant human tumor necrosis factor in vivo. Implications for mechanisms of action. J Immunol 1989;142:1405-9.10.4049/jimmunol.142.4.1405Search in Google Scholar