Human term placenta as source of stem cells for regenerative medicine

1. Parolini O, De D, Rodrigues MF, and Caruso M Placental Stem/Progenitor Cells: Isolation and Characterization, in Perinatal Stem Cells, A. Atala and S.V. Murphy, Editors. 2014, Springer Science: New York. p.373.10.1007/978-1-4939-1118-9_13Search in Google Scholar

2. Debashree D, Kmiecik G, Cargnoni A, and Parolini O Placenta-Derived Cells and Their Therapeutic Applications, in Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, N.S. Templeton, Editor. 2015, CRC Press.10.1201/b18002-35Search in Google Scholar

3. Parolini O and Soncini M Placenta as a Source of Stem Cells and as a Key Organ for Fetomaternal Tolerance, in Regenerative Medicine Using Pregnancy-Specific Biological Substances, N. Bhattacharya and P. Stubblefield, Editors. 2011, Springer-Verlag: London. p. 460.10.1007/978-1-84882-718-9_2Search in Google Scholar

4. Parolini O, Alviano F, Bagnara GP, Bilic G, Buhring HJ, Evangelista M, Hennerbichler S, Liu B, Magatti M, Mao N, Miki T, Marongiu F, Nakajima H, Nikaido T, Portmann-Lanz CB, Sankar V, Soncini M, Stadler G, Surbek D, Takahashi TA, Redl H, Sakuragawa N, Wolbank S, Zeisberger S, Zisch A, and Strom SC Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells. 2008; 26(2):300-11.Search in Google Scholar

5. Fukuchi Y, Nakajima H, Sugiyama D, Hirose I, Kitamura T, and Tsuji K Human placenta-derived cells have mesenchymal stem/progenitor cell potential. Stem Cells. 2004; 22(5):649-58.10.1634/stemcells.22-5-64915342929Open DOISearch in Google Scholar

6. Igura K, Zhang X, Takahashi K, Mitsuru A, Yamaguchi S, and Takashi TA Isolation and characterization of mesenchymal progenitor cells from chorionic villi of human placenta. Cytotherapy. 2004; 6(6):543-53.10.1080/14653240410005366-115770794Open DOISearch in Google Scholar

7. Portmann-Lanz CB, Schoeberlein A, Huber A, Sager R, Malek A, Holzgreve W, and Surbek DV Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration. Am J Obstet Gynecol. 2006; 194(3):664-73.10.1016/j.ajog.2006.01.10116522395Search in Google Scholar

8. Castrechini NM, Murthi P, Gude NM, Erwich JJ, Gronthos S, Zannettino A, Brennecke SP, and Kalionis B Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche. Placenta. 2010;31(3):203-12.10.1016/j.placenta.2009.12.00620060164Search in Google Scholar

9. In ‘t Anker PS, Scherjon SA, Kleijburg-van der Keur C, de Groot-Swings GM, Claas FH, Fibbe WE, and Kanhai HH Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells. 2004; 22(7):1338-45.10.1634/stemcells.2004-005815579651Search in Google Scholar

10. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, and Chen CC Mesenchymal stem cells in the Wharton’s jelly of the human umbilical cord. Stem Cells. 2004; 22(7):1330-7.10.1634/stemcells.2004-001315579650Search in Google Scholar

11. Troyer DL and Weiss ML Wharton’s jelly-derived cells are a primitive stromal cell population. Stem Cells. 2008; 26(3):591-9. 10.1634/stemcells.2007-0439331122618065397Open DOISearch in Google Scholar

12. La Rocca G, Anzalone R, Corrao S, Magno F, Loria T, Lo Iacono M, Di Stefano A, Giannuzzi P, Marasa L, Cappello F, Zummo G, and Farina F Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers. Histochem Cell Biol. 2009; 131(2):267-82.10.1007/s00418-008-0519-318836737Search in Google Scholar

13. Robin C and Dzierzak E Preparation of hematopoietic stem and progenitor cells from the human placenta. Curr Protoc Stem Cell Biol. 2010; Chapter 2:Unit 2A 9.10.1002/9780470151808.sc02a09s1420814938Search in Google Scholar

14. Dzierzak E and Robin C Placenta as a source of hematopoietic stem cells. Trends Mol Med. 2010; 16(8):361-7.10.1016/j.molmed.2010.05.005358631420580607Search in Google Scholar

15. Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE, and Scott EW Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature. 2002; 416(6880):542-5.10.1038/nature73011932747Search in Google Scholar

16. Nygren JM, Jovinge S, Breitbach M, Sawen P, Roll W, Hescheler J, Taneera J, Fleischmann BK, and Jacobsen SE Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med. 2004; 10(5):494-501.10.1038/nm104015107841Open DOISearch in Google Scholar

17. Manuelpillai U, Tchongue J, Lourensz D, Vaghjiani V, Samuel CS, Liu A, Williams ED, and Sievert W Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl(4)-treated mice. Cell Transplant. 2010; 19(9):1157-68.10.3727/096368910X50449620447339Search in Google Scholar

18. Manuelpillai U, Lourensz D, Vaghjiani V, Tchongue J, Lacey D, Tee JY, Murthi P, Chan J, Hodge A, and Sievert W Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis. PLoS One. 2012; 7(6):e38631.10.1371/journal.pone.0038631337529622719909Search in Google Scholar

19. Cargnoni A, Gibelli L, Tosini A, Signoroni PB, Nassuato C, Arienti D, Lombardi G, Albertini A, Wengler GS, and Parolini O Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin- induced lung fibrosis. Cell Transplant. 2009; 18(4):405-22.10.3727/09636890978880985719622228Open DOISearch in Google Scholar

20. Moodley Y, Ilancheran S, Samuel C, Vaghjiani V, Atienza D, Williams ED, Jenkin G, Wallace E, Trounson A, and Manuelpillai U Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair. Am J Respir Crit Care Med. 2010; 182(5):643-51.10.1164/rccm.201001-0014OC20522792Search in Google Scholar

21. Murphy SV, Shiyun SC, Tan JL, Chan S, Jenkin G, Wallace EM, and Lim R Human amnion epithelial cells do not abrogate pulmonary fibrosis in mice with impaired macrophage function. Cell Transplant. 2012; 21(7):1477-92.10.3727/096368911X60102822507554Open DOISearch in Google Scholar

22. Murphy S, Lim R, Dickinson H, Acharya R, Rosli S, Jenkin G, and Wallace E Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function. Cell Transplant. 2011; 20(6):909-23.10.3727/096368910X54338521092408Open DOISearch in Google Scholar

23. Vosdoganes P, Wallace EM, Chan ST, Acharya R, Moss TJ, and Lim R Human amnion epithelial cells repair established lung injury. Cell Transplant. 2013; 22(8):1337-49.10.3727/096368912X65765723044339Search in Google Scholar

24. Tan JL, Chan ST, Wallace EM, and Lim R Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization. Cell Transplant. 2014; 23(3):319-28.10.3727/096368912X66140923294809Open DOISearch in Google Scholar

25. Parolini O, Souza-Moreira L, O’Valle F, Magatti M, Hernandez-Cortes P, Gonzalez-Rey E, and Delgado M Therapeutic effect of human amniotic membrane-derived cells on experimental arthritis and other inflammatory disorders. Arthritis Rheumatol. 2014; 66(2):327-39.10.1002/art.3820624504805Search in Google Scholar

26. Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, and Sakamoto N Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats. Cell Transplant. 2015; 24(12):2601-14.10.3727/096368915X68757025812083Search in Google Scholar

27. Pischiutta F, Brunelli L, Romele P, Silini A, Sammali E, Paracchini L, Marchini S, Talamini L, Bigini P, Boncoraglio GB, Pastorelli R, De Simoni MG, Parolini O, and Zanier ER Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites. Crit Care Med.2016.10.1097/CCM.000000000000186427441900Search in Google Scholar

28. Yan ZJ, Zhang P, Hu YQ, Zhang HT, Hong SQ, Zhou HL, Zhang MY, and Xu RX Neural stem-like cells derived from human amnion tissue are effective in treating traumatic brain injury in rat. Neurochem Res. 2013; 38(5):1022-33.10.1007/s11064-013-1012-523475428Open DOISearch in Google Scholar

29. Ventura C, Cantoni S, Bianchi F, Lionetti V, Cavallini C, Scarlata I, Foroni L, Maioli M, Bonsi L, Alviano F, Fossati V, Bagnara GP, Pasquinelli G, Recchia FA, and Perbellini A Hyaluronan mixed esters of butyric and retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts. J Biol Chem. 2007; 282(19):14243-52.10.1074/jbc.M60935020017363374Search in Google Scholar

30. Tsuji H, Miyoshi S, Ikegami Y, Hida N, Asada H, Togashi I, Suzuki J, Satake M, Nakamizo H, Tanaka M, Mori T, Segawa K, Nishiyama N, Inoue J, Makino H, Miyado K, Ogawa S, Yoshimura Y, and Umezawa A Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes. Circ Res. 2010; 106(10):1613-23.Search in Google Scholar

31. Fang CH, Jin J, Joe JH, Song YS, So BI, Lim SM, Cheon GJ, Woo SK, Ra JC, Lee YY, and Kim KS In vivo differentiation of human amniotic epithelial cells into cardiomyocyte-like cells and cell transplantation effect on myocardial infarction in rats: comparison with cord blood and adipose tissue-derived mesenchymal stem cells. Cell Transplant. 2012; 21(8):1687-96.10.3727/096368912X65303922776022Search in Google Scholar

32. Vosdoganes P, Lim R, Koulaeva E, Chan ST, Acharya R, Moss TJ, and Wallace EM Human amnion epithelial cells modulate hyperoxia-induced neonatal lung injury in mice. Cytotherapy. 2013; 15(8):1021-9.10.1016/j.jcyt.2013.03.00423643416Search in Google Scholar

33. Hodges RJ, Jenkin G, Hooper SB, Allison B, Lim R, Dickinson H, Miller SL, Vosdoganes P, and Wallace EM Human amnion epithelial cells reduce ventilation-induced preterm lung injury in fetal sheep. Am J Obstet Gynecol. 2012; 206(5):448 e8-15.10.1016/j.ajog.2012.02.03822542124Search in Google Scholar

34. Vosdoganes P, Hodges RJ, Lim R, Westover AJ, Acharya RY, Wallace EM, and Moss TJ Human amnion epithelial cells as a treatment for inflammation- induced fetal lung injury in sheep. Am J Obstet Gynecol. 2011; 205(2):156 e26-33.10.1016/j.ajog.2011.03.05421640967Search in Google Scholar

35. Barboni B, Russo V, Curini V, Mauro A, Martelli A, Muttini A, Bernabo N, Valbonetti L, Marchisio M, Di Giacinto O, Berardinelli P, and Mattioli M Achilles tendon regeneration can be improved by amniotic epithelial cell allotransplantation. Cell Transplant. 2012; 21(11):2377-95.10.3727/096368912X63889222507232Open DOISearch in Google Scholar

36. Mauro A, Russo V, Di Marcantonio L, Berardinelli P, Martelli A, Muttini A, Mattioli M, and Barboni B M1 and M2 macrophage recruitment during tendon regeneration induced by amniotic epithelial cell allotransplantation in ovine. Research in Veterinary Science. 2016; 105:92-102.10.1016/j.rvsc.2016.01.01427033915Open DOISearch in Google Scholar

37. Kranz A, Wagner DC, Kamprad M, Scholz M, Schmidt UR, Nitzsche F, Aberman Z, Emmrich F, Riegelsberger UM, and Boltze J Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats. Brain Res. 2010; 1315:128-36.10.1016/j.brainres.2009.12.00120004649Search in Google Scholar

38. Zhao B, Liu JQ, Zheng Z, Zhang J, Wang SY, Han SC, Zhou Q, Guan H, Li C, Su LL, and Hu DH Human amniotic epithelial stem cells promote wound healing by facilitating migration and proliferation of keratinocytes via ERK, JNK and AKT signaling pathways. Cell Tissue Res. 2016; 365(1):85-99.10.1007/s00441-016-2366-126888423Search in Google Scholar

39. Jin E, Kim TH, Han S, and Kim SW Amniotic epithelial cells promote wound healing in mice through high epithelialization and engraftment. J Tissue Eng Regen Med. 2015.10.1002/term.206926174407Search in Google Scholar

40. Cargnoni A, Piccinelli EC, Ressel L, Rossi D, Magatti M, Toschi I, Cesari V, Albertini M, Mazzola S, and Parolini O Conditioned medium from amniotic membrane-derived cells prevents lung fibrosis and preserves blood gas exchanges in bleomycin-injured mice-specificity of the effects and insights into possible mechanisms. Cytotherapy. 2014; 16(1):17-32.10.1016/j.jcyt.2013.07.00224094500Open DOISearch in Google Scholar

41. Cargnoni A, Ressel L, Rossi D, Poli A, Arienti D, Lombardi G, and Parolini O Conditioned medium from amniotic mesenchymal tissue cells reduces progression of bleomycin-induced lung fibrosis. Cytotherapy. 2012; 14(2):153-61.10.3109/14653249.2011.613930327914021954836Open DOISearch in Google Scholar

42. Danieli P, Malpasso G, Ciuffreda MC, Cervio E, Calvillo L, Copes F, Pisano F, Mura M, Kleijn L, de Boer RA, Viarengo G, Rosti V, Spinillo A, Roccio M, and Gnecchi M Conditioned medium from human amniotic mesenchymal stromal cells limits infarct size and enhances angiogenesis. Stem Cells Transl Med. 2015; 4(5):448-58.10.5966/sctm.2014-0253441422425824141Search in Google Scholar

43. Magatti M, Vertua E, De Munari S, Caro M, Caruso M, Silini A, Delgado M, and Parolini O Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features. J Tissue Eng Regen Med. 2016.10.1002/term.2193569770027396853Search in Google Scholar

44. Lange-Consiglio A, Rossi D, Tassan S, Perego R, Cremonesi F, and Parolini O Conditioned medium from horse amniotic membrane-derived multipotent progenitor cells: immunomodulatory activity in vitro and first clinical application in tendon and ligament injuries in vivo. Stem Cells Dev. 2013; 22(22):3015-24.10.1089/scd.2013.021423795963Open DOISearch in Google Scholar

45. Kim TH, Park YW, Ahn JS, Ahn JT, Kim SE, Jeong MB, Seo MS, Kang KS, and Seo KM Effects of conditioned media from human amniotic epithelial cells on corneal alkali injuries in rabbits. J Vet Sci. 2013; 14(1):61-7.10.4142/jvs.2013.14.1.61361523323388445Open DOISearch in Google Scholar

46. Wichayacoop T, Briksawan P, Tuntivanich P, and Yibchok-Anun S Anti- inflammatory effects of topical supernatant from human amniotic membrane cell culture on canine deep corneal ulcer after human amniotic membrane transplantation. Vet Ophthalmol. 2009; 12(1):28-35.10.1111/j.1463-5224.2009.00670.x19152595Open DOISearch in Google Scholar

47. Ricci E, Vanosi G, Lindenmair A, Hennerbichler S, Peterbauer-Scherb A, Wolbank S, Cargnoni A, Signoroni PB, Campagnol M, Gabriel C, Redl H, and Parolini O Anti-fibrotic effects of fresh and cryopreserved human amniotic membrane in a rat liver fibrosis model. Cell Tissue Bank. 2013; 14(3):475-88.10.1007/s10561-012-9337-x22926336Open DOISearch in Google Scholar

48. Sant’Anna LB, Cargnoni A, Ressel L, Vanosi G, and Parolini O Amniotic membrane application reduces liver fibrosis in a bile duct ligation rat model. Cell Transplant. 2011; 20(3):441-53.10.3727/096368910X52225220719087Open DOISearch in Google Scholar

49. Cargnoni A, Di Marcello M, Campagnol M, Nassuato C, Albertini A, and Parolini O Amniotic membrane patching promotes ischemic rat heart repair. Cell Transplant. 2009; 18(10):1147-59.Search in Google Scholar

50. Magatti M, De Munari S, Vertua E, Gibelli L, Wengler GS, and Parolini O Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities. Stem Cells. 2008; 26(1):182-92.10.1634/stemcells.2007-049117901399Open DOISearch in Google Scholar

51. Magatti M, De Munari S, Vertua E, Nassauto C, Albertini A, Wengler GS, and Parolini O Amniotic mesenchymal tissue cells inhibit dendritic cell differentiation of peripheral blood and amnion resident monocytes. Cell Transplant. 2009; 18(8):899-914.10.3727/096368909X47131419523334Search in Google Scholar

52. Magatti M, Caruso M, De Munari S, Vertua E, De D, Manuelpillai U, and Parolini O Human Amniotic Membrane-Derived Mesenchymal and Epithelial Cells Exert Different Effects on Monocyte-Derived Dendritic Cell Differentiation and Function. Cell Transplant. 2015; 24(9):1733-52.10.3727/096368914X68403325259480Search in Google Scholar

53. Rossi D, Pianta S, Magatti M, Sedlmayr P, and Parolini O Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity. PLoS One. 2012; 7(10):e46956.10.1371/journal.pone.0046956346861423071674Search in Google Scholar

54. Pianta S, Bonassi Signoroni P, Muradore I, Rodrigues MF, Rossi D, Silini A, and Parolini O Amniotic membrane mesenchymal cells-derived factors skew T cell polarization toward Treg and downregulate Th1 and Th17 cells subsets. Stem Cell Rev. 2015; 11(3):394-407.10.1007/s12015-014-9558-4445147225348066Search in Google Scholar