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Survival of node-negative breast cancer patients treated at the university medical centre Maribor in the period 2000–2009

Nina Fokter Dovnik
Nina Fokter Dovnik
, 
Darja Arko
Darja Arko
, 
Nina Čas Sikošek
Nina Čas Sikošek
 and 
Iztok Takač
Iztok Takač
   | May 26, 2017
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Article Category: Original scientific article
Published Online: May 26, 2017
Page range: 185 - 192
Received: May 21, 2016
Accepted: Apr 21, 2017
DOI: https://doi.org/10.1515/sjph-2017-0025
Keywords
© National Institute of Public Health, Slovenia
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Kaplan-Meier plot of overall survival (OS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor, according to the period of diagnosis (N=858). The difference in OS between the two periods of diagnosis is not statistically significant (p=0.086).
Kaplan-Meier plot of overall survival (OS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor, according to the period of diagnosis (N=858). The difference in OS between the two periods of diagnosis is not statistically significant (p=0.086).

Figure 2

Kaplan-Meier plot of overall survival (OS) probability for all Slovenian node-negative breast cancer patients according to the period of diagnosis (N=4740). OS was significantly better for patients diagnosed in the period 2005–2009, compared to those diagnosed in the period 2000–2004 (p<0.001).
Kaplan-Meier plot of overall survival (OS) probability for all Slovenian node-negative breast cancer patients according to the period of diagnosis (N=4740). OS was significantly better for patients diagnosed in the period 2005–2009, compared to those diagnosed in the period 2000–2004 (p<0.001).

Figure 3

Kaplan-Meier plot of overall survival (OS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858), compared to all Slovenian node-negative breast cancer patients (N=4740) diagnosed in the period 2000–2009. No difference in OS was observed (p=0.413). The fi nal part of the line representing the Maribor data is less reliable, because of the small number of patients at risk.
Kaplan-Meier plot of overall survival (OS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858), compared to all Slovenian node-negative breast cancer patients (N=4740) diagnosed in the period 2000–2009. No difference in OS was observed (p=0.413). The fi nal part of the line representing the Maribor data is less reliable, because of the small number of patients at risk.

Figure 4

Kaplan-Meier plot of breast cancer specifi c survival (BCSS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor, according to the period of diagnosis (N=858). BCSS was significantly better for patients diagnosed in the period 2005–2009, compared to the patients diagnosed in the period 2000–2004 (p=0.028).
Kaplan-Meier plot of breast cancer specifi c survival (BCSS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor, according to the period of diagnosis (N=858). BCSS was significantly better for patients diagnosed in the period 2005–2009, compared to the patients diagnosed in the period 2000–2004 (p=0.028).

Figure 5

Kaplan-Meier plot of breast cancer specifi c survival (BCSS) probability for all Slovenian node-negative breast cancer patients according to the period of diagnosis (N=4740). BCSS was significantly better for patients diagnosed in the period 2005–2009, compared to those diagnosed in the period 2000–2004 (p<0.001).
Kaplan-Meier plot of breast cancer specifi c survival (BCSS) probability for all Slovenian node-negative breast cancer patients according to the period of diagnosis (N=4740). BCSS was significantly better for patients diagnosed in the period 2005–2009, compared to those diagnosed in the period 2000–2004 (p<0.001).

Figure 6

Kaplan-Meier plot of breast cancer specifi c survival (BCSS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858), compared to all Slovenian nodenegative breast cancer patients (N=4740) diagnosed in the period 2000–2009. No difference in BCSS was observed (p=0.233).
Kaplan-Meier plot of breast cancer specifi c survival (BCSS) probability for node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858), compared to all Slovenian nodenegative breast cancer patients (N=4740) diagnosed in the period 2000–2009. No difference in BCSS was observed (p=0.233).

Comparison of 1-, 3- and 5-year overall survival (OS) probabilities for node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858) and in Slovenia (N=4740) in the period 2000–2009. The only statistically significant OS difference was observed between the two periods in Slovenian patients (p<0.001).

MariborSlovenia
2000-20042005-20092000-20042005-2009
OS%95% CI%95% CI%95% CI%95% CI
1-year98.797.5-99.999.498.6-10098.998.5-99.399.098.6-99.4
3-year94.391.9-96.796.795.1-98.395.294.2-96.295.594.7-96.3
5-year89.286.1-92.394.692.6-96.690.188.9-91.392.491.4-93.4

Comparison of 1-, 3- and 5-year breast cancer specifi c survival (BCSS) probabilities for node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858) and in Slovenia (N=4740) in the period 2000–2009. Statistically significant BCSS differences were observed between the two periods in patients treated in Maribor (p=0.028) and in all Slovenian patients (p<0.001). No differences were observed according to the site of treatment (p=0.233).

MariborSlovenia
2000-20042005-20092000-20042005-2009
BCSS%95% CI%95% CI%95% CI%95% CI
1-year99.598.7-10010099.6-10099.499.0-99.899.499.0-99.8
3-year97.595.9-99.198.397.1-99.597.396.7-97.997.396.7-97.9
5-year95.393.1-97.497.395.9-98.794.593.5-95.595.694.8-96.4

Multivariate analysis of factors influencing overall survival (OS) and breast cancer specific survival (BCSS) in node-negative breast cancer patients treated at the University Medical Centre Maribor in the period 2000–2009 (N=858).

OSBCSS
  FactorHR (95% CI)pHR (95% CI)p
Treatment period
(2005-2009 vs. 2000-2004)0.63 (0.44-0.90)0.0110.51 (0.29-0.91)0.021
Adjuvant radiotherapy
(yes vs. no)0.36 (0.22-0.57)<0.0010.41 (0.22-0.76)0.005
Adjuvant chemotherapy
(yes vs. no)0.56 (0.36-0.85)0.0070.39 (0.20-0.78)0.007
Age<0.0010.105
<40 years vs. ≥70 years0.55 (0.22-1.42)0.2172.17 (0.77-6.13)0.142
40-70 years vs. ≥70 years0.33 (0.23-0.49)<0.0010.80 (0.45-1.42)0.442

Characteristics of node-negative breast cancer patients treated at the University Medical Centre Maribor (N=858) and in Slovenia (N=4740) in the period 2000–2009.

Maribor N (%)Slovenia N (%)
Time period
  2000-2004373 (43.5)2253 (47.5)
  2005-2009485 (56.5)2487 (52.5)
Age
  <40 years37 (4.3)208 (4.4)
  ≥40 and <70 years561 (65.4)3316 (70.0)
  ≥70 years260 (30.3)1216 (25.6)
Postoperative radiation therapy
  no439 (51.2)2504 (52.8)
  yes419 (48.8)2236 (47.2)
Adjuvant systemic therapy
  no71 (8.3)839 (17.7)
  yes787 (91.7)3901 (82.3)

Multivariate analysis of factors influencing overall survival (OS) and breast cancer specific survival (BCSS) in node-negative breast cancer patients treated in Slovenia in the period 2000–2009 (N=4740).

OSBCSS
  FactorHR (95% CI)pHR (95% CI)p
Treatment period
(2005-2009 vs. 2000-2004)0.76 (0.66-0.88)<0.0010.67 (0.55-0.82)<0.001
Adjuvant radiotherapy
(yes vs. no)0.60 (0.51-0.71)<0.0010.65 (0.52-0.81)<0.001
Adjuvant chemotherapy
(yes vs. no)0.75 (0.65-0.87)<0.0010.77 (0.62-0.96)0.019
Age<0.001<0.001
<40 years vs. ≥70 years0.37 (0.26-0.54)<0.0010.86 (0.57-1.30)0.475
40-70 years vs. ≥70 years0.30 (0.26-0.34)<0.0010.47 (0.38-0.58)<0.001
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