<abstract xmlns="http://www.w3.org/1999/xhtml">Febrile conditions of unidentified origin are still unknown in modern medicine despite the development of diagnostic procedures. There are various agents of long-term temperature encompassing numerous infectious or non-infectious diseases.The aim of this study was to determine if there was a statistically significant difference in the values of proinflammatory cytokines (IL-1, TNFα, IL-6) in patients who meet the criteria for febrile conditions of unidentified origin, between the group of infectious, malignant, rheumatic, “other” diseases and undiagnosed patients.The study was conducted in the Immunology laboratory of the Center for Molecular Medicine and Stem Cells Research of the Faculty of Medical Sciences in Kragujevac. Blood samples were taken from patients tested at the Clinic for Infectious Diseases, of the Clinical Center of Kragujevac, in the period from 2014 to 2016. The study included 70 patients.The measured values of the level of TNFα showed significantly higher values in a group of malignant diseases than in the group of infectious diseases, while the values of IL-1 and IL-6 did not show statistical significance.TNFα can improve diagnosing in case of patients with an unknown febrile condition, which can shorten the length of the hospital stay and reduce the volume of performance of diagnostic procedures.</abstract>

Febrile conditions of unidentified origin are still unknown in modern medicine despite the development of diagnostic procedures. There are various agents of long-term temperature encompassing numerous infectious or non-infectious diseases.The aim of this study was to determine if there was a statistically significant difference in the values of proinflammatory cytokines (IL-1, TNFα, IL-6) in patients who meet the criteria for febrile conditions of unidentified origin, between the group of infectious, malignant, rheumatic, “other” diseases and undiagnosed patients.The study was conducted in the Immunology laboratory of the Center for Molecular Medicine and Stem Cells Research of the Faculty of Medical Sciences in Kragujevac. Blood samples were taken from patients tested at the Clinic for Infectious Diseases, of the Clinical Center of Kragujevac, in the period from 2014 to 2016. The study included 70 patients.The measured values of the level of TNFα showed significantly higher values in a group of malignant diseases than in the group of infectious diseases, while the values of IL-1 and IL-6 did not show statistical significance.TNFα can improve diagnosing in case of patients with an unknown febrile condition, which can shorten the length of the hospital stay and reduce the volume of performance of diagnostic procedures.

Tumor Necrosis Factor-Alpha as Differential Diagnostic Marker for Patients with Fever of Unknown Origin

Department of Infectious diseases, Faculty of Medical Sciences

Department of Biochemistry, Faculty of Medical Sciences

Department of Internal medicine, Faculty of Medical Sciences

Department of Microbiology and immunology, Faculty of Medical Sciences

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences

Department of Histology and embryology, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Febrile conditions of unidentified origin are still unknown in modern medicine despite the development of diagnostic procedures. There are various agents of...

Tumor Necrosis Factor-Alpha as Differential Diagnostic Marker for Patients with Fever of Unknown Origin

Published Online: May 16, 2019

Page range: 33 - 38

Received: Apr 04, 2017

Accepted: May 18, 2017

DOI: https://doi.org/10.1515/sjecr-2017-0023

Keywords
temperature, temperature of an unknown cause, IL-1, TNFα, IL-6

© 2019 Biljana Popovska-Jovicic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Tumor Necrosis Factor-Alpha as Differential Diagnostic Marker for Patients with Fever of Unknown Origin

Published Online: May 16, 2019

Page range: 33 - 38

Received: Apr 04, 2017

Accepted: May 18, 2017

DOI: https://doi.org/10.1515/sjecr-2017-0023

Keywordstemperature, temperature of an unknown cause, IL-1, TNFα, IL-6

© 2019 Biljana Popovska-Jovicic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
temperature, temperature of an unknown cause, IL-1, TNFα, IL-6