<abstract xmlns="http://www.w3.org/1999/xhtml">Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2−), superoxide anion radicals (O2−), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors.Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism.Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia</abstract>

Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2−), superoxide anion radicals (O2−), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors.Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism.Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia

Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart

Department of Pharmaceutical chemistry, Faculty of Medical Sciences

Department of Physiology, Faculty of Medical Sciences

Department of Pharmacy, Faculty of Medical Sciences

1st Moscow State Medical University IM Sechenov

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2−), superoxide anion radicals (O2−), index of...

Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart

Published Online: Jul 17, 2018

Page range: 131 - 139

Received: Mar 11, 2017

Accepted: Mar 14, 2017

DOI: https://doi.org/10.1515/sjecr-2017-0008

Keywords
ischemic preconditioning, myocardial infarction, proton pump inhibitors, oxidative stress

© 2018 Nevena Jeremic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart

Published Online: Jul 17, 2018

Page range: 131 - 139

Received: Mar 11, 2017

Accepted: Mar 14, 2017

DOI: https://doi.org/10.1515/sjecr-2017-0008

Keywordsischemic preconditioning, myocardial infarction, proton pump inhibitors, oxidative stress

© 2018 Nevena Jeremic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ischemic preconditioning, myocardial infarction, proton pump inhibitors, oxidative stress