<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Coronary heart disease is the leading cause of mortality and morbidity worldwide. The effects of coronary heart disease are usually attributable to the detrimental effects of acute myocardial ischaemia-reperfusion injury. Newer strategies such as ischaemic or pharmacological preconditioning have been shown to condition the myocardium to ischaemia-reperfusion injury and thus reduce the final infarct size. This review investigates the role of calcium channel blockers in myocardial preconditioning. Additionally, special attention is given to nicorandil whose mechanism of action may be associated with the cardioprotective effects of preconditioning. There are still many uncertainties in understanding the role of these agents in preconditioning, but future research in this direction will certainly help reduce coronary heart disease.</p></abstract>

Coronary heart disease is the leading cause of mortality and morbidity worldwide. The effects of coronary heart disease are usually attributable to the detrimental effects of acute myocardial ischaemia-reperfusion injury. Newer strategies such as ischaemic or pharmacological preconditioning have been shown to condition the myocardium to ischaemia-reperfusion injury and thus reduce the final infarct size. This review investigates the role of calcium channel blockers in myocardial preconditioning. Additionally, special attention is given to nicorandil whose mechanism of action may be associated with the cardioprotective effects of preconditioning. There are still many uncertainties in understanding the role of these agents in preconditioning, but future research in this direction will certainly help reduce coronary heart disease.

Role of Calcium Channel Blockers in Myocardial Preconditioning

Department of Pharmacy, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Role of Calcium Channel Blockers in Myocardial Preconditioning"}

Coronary heart disease is the leading cause of mortality and morbidity worldwide. The effects of coronary heart disease are usually attributable to the...

Role of Calcium Channel Blockers in Myocardial Preconditioning

Published Online: Dec 29, 2017

Page range: 281 - 287

Received: May 10, 2016

Accepted: May 10, 2016

DOI: https://doi.org/10.1515/sjecr-2016-0073

Keywords
Preconditioning, Calcium channel blockers, Nicorandil

© 2017 Nina Simonovic et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Role of Calcium Channel Blockers in Myocardial Preconditioning

Published Online: Dec 29, 2017

Page range: 281 - 287

Received: May 10, 2016

Accepted: May 10, 2016

DOI: https://doi.org/10.1515/sjecr-2016-0073

KeywordsPreconditioning, Calcium channel blockers, Nicorandil

© 2017 Nina Simonovic et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Preconditioning, Calcium channel blockers, Nicorandil