<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used in the study. SUA levels were measured at 60 min of reperfusion for groups A and C and at 120 min of reperfusion for groups B and D. The drug U-74389G was administered only in groups C and D. U-74389G administration non-significantly increased the SUA levels by 15.43%±9.10% (p=0.096) at the representative endpoint of 1.5 h. The reperfusion time non-significantly decreased the SUA levels by 13.61%±9.18% (p=0.126). However, the interaction of U-74389G administration and reperfusion time non-significantly increased the SUA levels by 4.78%±5.64% (p= 0.387). Whether it interacted with the reperfusion time, U-74389G administration non-significantly increased SUA levels. It seems that U-74389G cannot reverse injury to IR tubular epithelial cells within 2 hours.</p></abstract>

This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used in the study. SUA levels were measured at 60 min of reperfusion for groups A and C and at 120 min of reperfusion for groups B and D. The drug U-74389G was administered only in groups C and D. U-74389G administration non-significantly increased the SUA levels by 15.43%±9.10% (p=0.096) at the representative endpoint of 1.5 h. The reperfusion time non-significantly decreased the SUA levels by 13.61%±9.18% (p=0.126). However, the interaction of U-74389G administration and reperfusion time non-significantly increased the SUA levels by 4.78%±5.64% (p= 0.387). Whether it interacted with the reperfusion time, U-74389G administration non-significantly increased SUA levels. It seems that U-74389G cannot reverse injury to IR tubular epithelial cells within 2 hours.

The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats

Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania,

Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki,

Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki,

Department of Biologic Chemistry, Athens University, Attiki,

Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki,

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of...

The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats

Published Online: Sep 24, 2016

Page range: 247 - 250

Received: Oct 29, 2015

Accepted: Mar 24, 2016

DOI: https://doi.org/10.1515/sjecr-2016-0035

Keywords
ischaemia, U-74389G, uric acid, reperfusion

© 2016 Constantinos Tsompos et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats

Published Online: Sep 24, 2016

Page range: 247 - 250

Received: Oct 29, 2015

Accepted: Mar 24, 2016

DOI: https://doi.org/10.1515/sjecr-2016-0035

Keywordsischaemia, U-74389G, uric acid, reperfusion

© 2016 Constantinos Tsompos et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ischaemia, U-74389G, uric acid, reperfusion