<abstract xmlns="http://www.w3.org/1999/xhtml">The femur transfers the body weight from the pelvic bone to the shinbone. Femur fractures are a significant cause of morbidity and mortality among the group of locomotor apparatus injuries, especially in the elderly population. Considering that oxidative stress occurs as a result of increased production of free radicals that damage cell function and cause numerous pathological conditions and diseases, the aim of this study was to investigate oxidative stress parameters in older patients with femoral neck fractures. This clinical study included 70 patients, of which 35 had femoral neck fractures (26 males and 9 females), while the other half of the patients formed the matched control group. Markers of oxidative stress (NO2−, TBARS, H2O2 and O2-) and anti-oxidative enzymes (SOD, CAT, and GSH) were measured. Results showed that the levels of O2- increased, while levels of NO2-, H2O2 and all the antioxidative enzymes decreased in patients with femoral neck fractures. These findings indicate that fractures cause oxidative stress, probably because of the reduced activity of osteoblasts and the increased activity of osteoclasts.</abstract>

The femur transfers the body weight from the pelvic bone to the shinbone. Femur fractures are a significant cause of morbidity and mortality among the group of locomotor apparatus injuries, especially in the elderly population. Considering that oxidative stress occurs as a result of increased production of free radicals that damage cell function and cause numerous pathological conditions and diseases, the aim of this study was to investigate oxidative stress parameters in older patients with femoral neck fractures. This clinical study included 70 patients, of which 35 had femoral neck fractures (26 males and 9 females), while the other half of the patients formed the matched control group. Markers of oxidative stress (NO2−, TBARS, H2O2 and O2-) and anti-oxidative enzymes (SOD, CAT, and GSH) were measured. Results showed that the levels of O2- increased, while levels of NO2-, H2O2 and all the antioxidative enzymes decreased in patients with femoral neck fractures. These findings indicate that fractures cause oxidative stress, probably because of the reduced activity of osteoblasts and the increased activity of osteoclasts.

Redox Status in Patients with Femoral Neck Fractures

Orthopedic and Traumatology Clinic, Podgorica, Montenegro

Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac,

Department of Orthopedics, Clinical Center of Kragujevac, Kragujevac

Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac,

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Redox Status in Patients with Femoral Neck Fractures"}

The femur transfers the body weight from the pelvic bone to the shinbone. Femur fractures are a significant cause of morbidity and mortality among the group of...

Redox Status in Patients with Femoral Neck Fractures

Published Online: Sep 24, 2016

Page range: 199 - 206

Received: Nov 06, 2015

Accepted: Dec 22, 2015

DOI: https://doi.org/10.1515/sjecr-2015-0061

Keywords
Oxidative stress, Antioxidant enzymes, Fracture, Femoral neck

© 2016 Goran Pesic et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Redox Status in Patients with Femoral Neck Fractures

Published Online: Sep 24, 2016

Page range: 199 - 206

Received: Nov 06, 2015

Accepted: Dec 22, 2015

DOI: https://doi.org/10.1515/sjecr-2015-0061

KeywordsOxidative stress, Antioxidant enzymes, Fracture, Femoral neck

© 2016 Goran Pesic et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Oxidative stress, Antioxidant enzymes, Fracture, Femoral neck