Expression Of The Bcl2 Gene In Chronic Lymphocytic Leukaemia Patients

1. Sagatys EM, Zhang L. Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia. Cancer Control 2012;19(1):18-25.10.1177/10732748120190010322143059Search in Google Scholar

2. Chiorazzi N. Implications of new prognostic markers in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2012;2012:76-87.10.1182/asheducation.V2012.1.76.3806845Search in Google Scholar

3. Obermann EC, Went P, Tzankov A, et al. Cell cycle phase distribution analysis in chronic lymphocytic leukaemia: a significant number of cells reside in early G1-phase. J Clin Pathol 2007;60(7):794-7.10.1136/jcp.2006.040956199579516950856Search in Google Scholar

4. Thomadaki H, Scorilas A. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Crit Rev Clin Lab Sci 2006;43(1):1-67.10.1080/1040836050029562616531274Search in Google Scholar

5. Garrido C, Galluzzi L, Brunet M, et al. Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 2006;13(9):1423-33.10.1038/sj.cdd.440195016676004Search in Google Scholar

6. Leibowitz B, Yu J. Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther 2010;9(6):417-22.10.4161/cbt.9.6.11392287411620190564Search in Google Scholar

7. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 2003;7(3):249-57.10.1111/j.1582-4934.2003.tb00225.x674133514594549Search in Google Scholar

8. Tzifi F, Economopoulou C, Gourgiotis D, et al. The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias. Adv Hematol 2012;2012:524308.10.1155/2012/524308317372821941553Search in Google Scholar

9. Mariano MT, Moretti L, Donelli A, et al. bcl-2 gene expression in hematopoietic cell differentiation. Blood 1992;80(3):768-75.10.1182/blood.V80.3.768.768Search in Google Scholar

10. Meijerink JP. t(14;18), a journey to eternity. Leukemia 1997;11(12):2175-87.10.1038/sj.leu.24008499447838Search in Google Scholar

11. Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 1993;82(6):1820-8.10.1182/blood.V82.6.1820.1820Search in Google Scholar

12. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002;99(24):15524-9.10.1073/pnas.24260679913775012434020Search in Google Scholar

13. Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005;102(39):13944-9.10.1073/pnas.0506654102123657716166262Search in Google Scholar

14. Nuckel H, Frey UH, Bau M, et al. Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia. Blood 2007;109(1):290-7.10.1182/blood-2006-03-00756716960146Search in Google Scholar

15. Majid A, Tsoulakis O, Walewska R, et al. BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism. Blood 2008;111(2):874-7.10.1182/blood-2007-07-09868117959858Search in Google Scholar

16. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000;343(26):1910-6.10.1056/NEJM20001228343260211136261Search in Google Scholar

17. Pettitt AR, Sherrington PD, Stewart G, et al. p53 dys-function in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood 2001;98(3):814-22.10.1182/blood.V98.3.81411468183Search in Google Scholar

18. Rossi D, Cerri M, Deambrogi C, et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin Cancer Res 2009;15(3):995-1004.10.1158/1078-0432.CCR-08-163019188171Search in Google Scholar

19. Cuni S, Perez-Aciego P, Perez-Chacon G, et al. A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia 2004;18(8):1391-400.10.1038/sj.leu.240339815175625Search in Google Scholar

20. Ringshausen I, Schneller F, Bogner C, et al. Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in BCLL: association with protein kinase Cdelta. Blood 2002;100(10):3741-8.10.1182/blood-2002-02-053912393602Search in Google Scholar

21. Barragan M, Bellosillo B, Campas C, et al. Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. Blood 2002;99(8):2969-76.10.1182/blood.V99.8.2969Search in Google Scholar

22. Hewamana S, Alghazal S, Lin TT, et al. The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 2008;111(9):4681-9.10.1182/blood-2007-11-12527818227347Search in Google Scholar

23. Panayiotidis P, Ganeshaguru K, Foroni L, Hoffbrand AV. Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. Leukemia 1995;9(7):1227-32.Search in Google Scholar

24. Osorio LM, Aguilar-Santelises M, De Santiago A, et al. Increased serum levels of soluble Fas in progressive BCLL. Eur J Haematol 2001;66(5):342-6.10.1034/j.1600-0609.2001.066005342.x11422415Search in Google Scholar

25. Pepper C, Lin TT, Pratt G, et al. Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood 2008;112(9):3807-17.10.1182/blood-2008-05-15713118599795Search in Google Scholar

26. Vogler M, Butterworth M, Majid A, et al. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood 2009;113(18):4403-13.10.1182/blood-2008-08-17331019008458Search in Google Scholar

27. Karan-Djurasevic T, Palibrk V, Zukic B, et al. Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers. Med Oncol 2013;30(1):405.10.1007/s12032-012-0405-723292833Search in Google Scholar

28. Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 1996;10(3):456-9.Search in Google Scholar

29. Caligaris-Cappio F, Hamblin TJ. B-cell chronic lymphocytic leukemia: a bird of a different feather. Journal of Clinical Oncology 1999;17:399-408.10.1200/JCO.1999.17.1.39910458259Search in Google Scholar

30. Faderl S, Keating MJ, Do KA, et al. Expression profile of 11 proteins and their prognostic significance in patients with chronic lymphocytic leukemia (CLL). Leukemia 2002;16(6):1045-52.10.1038/sj.leu.240254012040436Search in Google Scholar

31. Aviram A, Rabizadeh E, Zimra Y, et al. Expression of bcl-2 and bax in cells isolated from B-chronic lymphocytic leukemia patients at different stages of the disease. Eur J Haematol 2000;64(2):80-4.10.1034/j.1600-0609.2000.90042.x10997327Search in Google Scholar

32. Saxena A, Viswanathan S, Moshynska O, et al. Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia. Am J Hematol 2004;75(1):22-33.10.1002/ajh.1045314695629Search in Google Scholar

33. Packham G, Stevenson FK. Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia. Immunology 2005;114(4):441-9.10.1111/j.1365-2567.2005.02117.x178211815804279Search in Google Scholar

34. Placzek WJ, Wei J, Kitada S, et al. A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis 2010;1:e40.10.1038/cddis.2010.18303231221364647Search in Google Scholar

35. Rogalinska M, Franiak-Pietryga I, Blonski JZ, et al. Toward personalized therapy for chronic lymphocytic leukemia: DSC and cDNA microarray assessment of two cases. Cancer Biol Ther 2013;14(1):6-12.10.4161/cbt.22623356605423114648Search in Google Scholar