Serological Tests for Acquired Syphilis in Immuno-competent Patients

1. Larsen SA, Steiner BM, Rudolph AH. Laboratory diagnosis and interpretation of tests for syphilis. Clin Microbiol Rev. 1995;8(1):1-21.10.1128/CMR.8.1.1Search in Google Scholar

2. Stary A, Stary G. Sexually transmitted infections. In: Bolognia JL, Jorizzo JL, Schaffer JV. Dermatology. 3^rd ed. Philadelphia: Elsevier; 2012. p. 1367-89.Search in Google Scholar

3. Ratnam S. The laboratory diagnosis of syphilis. Can J Infect Dis Med Microbiol. 2005;16(1):45-51.10.1155/2005/597580Search in Google Scholar

4. Ray K, Lahta R, Sachdeva KG, Ganguly DD, Bhargava NC. Screening and confirmation of syphilis by serology - a five year experience. Indian J Sex Transm Dis. 1991;12:47-50.Search in Google Scholar

5. Workowski KA, Berman S, Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010;59(RR-12):1-110.Search in Google Scholar

6. Geusau A, Kittler H, Hein U, Dangl-Erlach E, Stingl G, Tschachler E. Biological false-positive tests comprise a high proportion of venereal disease research laboratory reactions in an analysis of 300,000 sera. Int J STD AIDS. 2005;16(11):722-6.10.1258/095646205774763207Search in Google Scholar

7. Soreng K, Levy R, Fakile Y. Serologic testing for syphilis: benefits and challenges of a reverse algorithm. Clinical Microbiology Newsletter. 2014;36(24):195-202.10.1016/j.clinmicnews.2014.12.001Search in Google Scholar

8. Janier M, Hegyi V, Dupin N, Unemo M, Tiplica GS, Potočnik M, et al. 2014 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2014;28(12):1581-93.10.1111/jdv.12734Search in Google Scholar

9. Lewis DA, Lukehart SA. Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: evolution, therapeutic challenges and the need to strengthen global surveillance. Sex Transm Infect. 2011;87 Suppl 2:ii39-43.10.1136/sti.2010.047712Search in Google Scholar

10. Romanowski B, Sutherland R, Fick GH, Mooney D, Love EJ. Serologic response to treatment of infectious syphilis. Ann Intern Med. 1991;114(12):1005-9.10.7326/0003-4819-114-12-1005Search in Google Scholar

11. Bosshard PP. Usefulness of IgM-specific enzyme immunoassays for serodiagnosis of syphilis: comparative evaluation of three different assays. J Infect. 2013;67(1):35-42.10.1016/j.jinf.2013.03.011Search in Google Scholar

12. Gutierrez J, Vergara MJ, Soto MJ, Piedrola G, Maroto Md. Clinical utility of a competitive ELISA to detect antibodies against Treponema pallidum. J Clin Lab Anal. 2000;14(2):83-6.10.1002/(SICI)1098-2825(2000)14:2<83::AID-JCLA8>3.0.CO;2-ASearch in Google Scholar

13. Sena AC, White BL, Sparling PF. Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century. Clin Infect Dis. 2010;51(6):700–8.10.1086/655832Search in Google Scholar

14. Hagedorn HJ. Laboratory diagnosis of syphilis. In: Gross G, Tyring SK, editors. Sexually transmitted infections and sexually transmitted diseases. Berlin: Springer-Verlag; 2011. p. 143-50.10.1007/978-3-642-14663-3_12Search in Google Scholar

15. Kingston M, French P, Goh B, Goold P, Higgins S, Sukthankar A, et al. UK National Guidelines on the Management of Syphilis 2008. Int J STD AIDS. 2008;19(11):729–40.10.1258/ijsa.2008.008279Search in Google Scholar

16. Tucker JD, Bu J, Brown LB, Yin YP, Chen XS, Cohen MS. Accelerating worldwide syphilis screening through rapid testing: a systematic review. Lancet Infect Dis. 2010;10(6):381-6.10.1016/S1473-3099(10)70092-XSearch in Google Scholar

17. Zanto SN. Changing algorithms in syphilis laboratory diagnosis. Clinical Microbiology Newsletter. 2010;32(8):59-64.10.1016/j.clinmicnews.2010.03.006Search in Google Scholar

18. Owusu-Edusei K Jr, Peterman TA, Ballard RC. Serologic testing for syphilis in the United States: a cost-effectiveness analysis of two screening algorithms. Sex Transm Dis. 2011;38(1):1–7.10.1097/OLQ.0b013e3181ec51f120739911Search in Google Scholar

19. Binnicker MJ. Which algorithm should be used to screen for syphilis? Curr Opin Infect Dis. 2012;25(1):79-85.10.1097/QCO.0b013e32834e9a3c22156894Search in Google Scholar

20. Centers for Disease Control and Prevention (CDC). Syphilis testing algorithms using treponemal tests for initial screening: four laboratories, New York City, 2005–2006. MMWR Morb Mortal Wkly Rep. 2008;57(32):872–5.Search in Google Scholar

21. Tong ML, Lin LR, Liu LL, Zhang HL, Huang SJ, Chen YY, et al. Analysis of 3 algorithms for syphilis serodiagnosis and implications for clinical management. Clin Infect Dis. 2014;58(8):1116–24.10.1093/cid/ciu08724550376Search in Google Scholar

22. Jost H, Castro A, Cox D, Fakile Y, Kikkert S, Tun Y, et al. A comparison of the analytical level of agreement of nine treponemal assays for syphilis and possible implications for screening algorithms. BMJ Open. 2013;3(9):e003347.10.1136/bmjopen-2013-003347378029924056483Search in Google Scholar

23. Malm K, Andersson S, Fredlund H, Norrgren H, Biague A, Mansson F, et al. Analytical evaluation of nine serological assays for diagnosis of syphilis. J Eur Acad Dermatol Venereol. 2015;29(12):2369-76.10.1111/jdv.1323726370737Search in Google Scholar

24. Gayet-Ageron A, Ninet B, Toutous-Trellu L, Lautenschlager S, Furrer H, Piguet V, et al. Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples. Sex Transm Infect. 2009;85(4):264–9.10.1136/sti.2008.03431419155240Search in Google Scholar

25. Castro AR, Mody HC, Parab SY, Patel MT, Kikkert SE, Park MM, et al. An immunofiltration device for the simultaneous detection of non-treponemal and treponemal antibodies in patients with syphilis. Sex Transm Infect. 2010;86(7):532–6.10.1136/sti.2010.042937Search in Google Scholar

26. Brown ST, Zaidi A, Larsen SA, Reynolds GH. Serological response to syphilis treatment. A new analysis of old data. JAMA. 1985;253(9):1296-9.10.1001/jama.1985.03350330094030Search in Google Scholar

27. Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention. MMWR Recomm Rep. 2002;51(RR-6):1-78.Search in Google Scholar

28. Wicher K, Horowitz HW, Wicher V. Laboratory methods of diagnosis of syphilis for the beginning of the third millennium. Microbes Infect. 1999;1(12):1035-49.10.1016/S1286-4579(99)80521-8Search in Google Scholar

29. Farhi D, Dupin N. Origins of syphilis and management in the immunocompetent patient: facts and controversies. Clin Dermatol. 2010;28(5):533–8.10.1016/j.clindermatol.2010.03.01120797514Search in Google Scholar

30. Smith NH, Musher DM, Huang DB, Rodriguez PS, Dowell ME, Ace W, et al. Response of HIV-infected patients with asymptomatic syphilis to intensive intramuscular therapy with ceftriaxone or procaine penicillin. Int J STD AIDS. 2004;15(5):328-32.10.1177/09564624040150051115117503Search in Google Scholar

31. Larsen SA, Hambie EA, Wobig GH, Kennedy EJ. Cerebrospinal serologic test for syphilis: treponemal and nontreponemal tests. In: Morisett R, Kurstak E, editors. Advances in sexually transmitted diseases. Utrecht: VNU Science Press; 1985. p. 157-62.Search in Google Scholar

32. Luger AF, Schmidt BL, Kaulich M. Significance of laboratory findings for the diagnosis of neurosyphilis. Int J STD AIDS. 2000;11(4):224-34.10.1258/095646200191575010772085Search in Google Scholar