<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has lead to a high need for developing new diagnostic strategies. Our aim was to evaluate the diagnostic performance of two routine hematologic indices for CD. Methods. In a prospective observational study, 34 newly diagnosed CD patients, 34 age-sex matched controls with irritable bowel syndrome (IBS) and 16 treated CD patients were assessed regarding the differences in mean lymphocyte count (LY), red blood cell distribution width (RDW) and their ratio (RDW/LY). <inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/7607_rrlm_45.jpg"></inline-graphic> Results. Elevated RDW (>14) and lymphopenia (&lt;1.5 x 10e9/L) were more frequently seen in newly diagnosed CD patients compared to IBS control group and treated CD patients. Newly diagnosed CD patients had significantly higher mean values of RDW/LY - 10.09, compared to 7.72 in the CD-treated group and 6.79 in IBS controls (p&lt;0.01). Subgroup analysis revealed that RDW/LY was higher in patients with destructive histology (Marsh≥3a), 10.54 vs. 7.99. For a value over 7, RDW/LY had a sensitivity of 88.24% (95% CI 72.55-96.70%) and AUROC of 0.785 (95% CI 0.683- 0.887). Conclusions. RDW/LY ratio is a widely available tool which could be used routinely in clinical practice for CD screening.</p></abstract>

Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has lead to a high need for developing new diagnostic strategies. Our aim was to evaluate the diagnostic performance of two routine hematologic indices for CD. Methods. In a prospective observational study, 34 newly diagnosed CD patients, 34 age-sex matched controls with irritable bowel syndrome (IBS) and 16 treated CD patients were assessed regarding the differences in mean lymphocyte count (LY), red blood cell distribution width (RDW) and their ratio (RDW/LY).  Results. Elevated RDW (>14) and lymphopenia (<1.5 x 10e9/L) were more frequently seen in newly diagnosed CD patients compared to IBS control group and treated CD patients. Newly diagnosed CD patients had significantly higher mean values of RDW/LY - 10.09, compared to 7.72 in the CD-treated group and 6.79 in IBS controls (p<0.01). Subgroup analysis revealed that RDW/LY was higher in patients with destructive histology (Marsh≥3a), 10.54 vs. 7.99. For a value over 7, RDW/LY had a sensitivity of 88.24% (95% CI 72.55-96.70%) and AUROC of 0.785 (95% CI 0.683- 0.887). Conclusions. RDW/LY ratio is a widely available tool which could be used routinely in clinical practice for CD screening.

Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has...

Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

Published Online: Jan 30, 2018

Page range: 45 - 50

Received: Aug 17, 2017

Accepted: Dec 15, 2017

DOI: https://doi.org/10.1515/rrlm-2017-0040

Keywords
celiac disease, screening, red blood cell distribution width, lymphopenia

© by Alina Popp

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

Published Online: Jan 30, 2018

Page range: 45 - 50

Received: Aug 17, 2017

Accepted: Dec 15, 2017

DOI: https://doi.org/10.1515/rrlm-2017-0040

Keywordsceliac disease, screening, red blood cell distribution width, lymphopenia

© by Alina Popp

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
celiac disease, screening, red blood cell distribution width, lymphopenia