<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Aim:</bold> The present study aim to analyze the relationship between GST M/T genotypes of glutathione S-transferases and cervical intraepithelial neoplasia.<bold>Materials and Methods:</bold> A prospective case-control study has been designed including 69 cases with different degrees of cervical dysplasia and 107 controls. All patients had been examined colposcopically. For every patient both cervical and blood specimen have been obtained. The peripheral blood was used for GST M/T genotyping. The statistical analysis was performed using OR and chi-square at a level of significance inferior to 0.05.<bold>Results:</bold> No statistically significant differences had been found between cases and controls for GST T-/M- geno-type (T-/M-, χ2=0.03, p= 0.8610) and T+/M+ χ2=0.65, p = 0.4197. Patients with in situ carcinoma had significant GST genotype association for T-/M+ genotype (OR=4.66, CI 95% [0.6528,24.9725], χ2=4.6, p=0.0314) and for T+/M- genotype (OR=0.12, CI 95% [0.0027,0.9465], χ2=0.05, p=0.0219).<bold>Conclusion:</bold> The combination of GST genotypes can be included in a predictive score for patients with cervical carcinoma.</abstract>

Aim: The present study aim to analyze the relationship between GST M/T genotypes of glutathione S-transferases and cervical intraepithelial neoplasia.Materials and Methods: A prospective case-control study has been designed including 69 cases with different degrees of cervical dysplasia and 107 controls. All patients had been examined colposcopically. For every patient both cervical and blood specimen have been obtained. The peripheral blood was used for GST M/T genotyping. The statistical analysis was performed using OR and chi-square at a level of significance inferior to 0.05.Results: No statistically significant differences had been found between cases and controls for GST T-/M- geno-type (T-/M-, χ2=0.03, p= 0.8610) and T+/M+ χ2=0.65, p = 0.4197. Patients with in situ carcinoma had significant GST genotype association for T-/M+ genotype (OR=4.66, CI 95% [0.6528,24.9725], χ2=4.6, p=0.0314) and for T+/M- genotype (OR=0.12, CI 95% [0.0027,0.9465], χ2=0.05, p=0.0219).Conclusion: The combination of GST genotypes can be included in a predictive score for patients with cervical carcinoma.

Genetic polymorphisms of glutathione S transferase and cervical intraepithelial neoplasia

Department of Mother and the Baby, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj Napoca,

Department of Molecular Sciences, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj Napoca,

Department of Economic Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca,

1 Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj Napoca,

Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca,

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Aim: The present study aim to analyze the relationship between GST M/T genotypes of glutathione S-transferases and cervical intraepithelial neoplasia.Materials...

Genetic polymorphisms of glutathione S transferase and cervical intraepithelial neoplasia

Published Online: Dec 30, 2016

Page range: 377 - 386

Received: Apr 26, 2016

Accepted: Sep 26, 2016

DOI: https://doi.org/10.1515/rrlm-2016-0036

Keywords
cervical intraepithelial neoplasia, HPV, SNP, GST

© 2016 Mureșan Daniel et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Genetic polymorphisms of glutathione S transferase and cervical intraepithelial neoplasia

Published Online: Dec 30, 2016

Page range: 377 - 386

Received: Apr 26, 2016

Accepted: Sep 26, 2016

DOI: https://doi.org/10.1515/rrlm-2016-0036

Keywordscervical intraepithelial neoplasia, HPV, SNP, GST

© 2016 Mureșan Daniel et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
cervical intraepithelial neoplasia, HPV, SNP, GST