[1. Hervald H, Egesten A. Sepsis - Pro-Inflammatory and Anti-Inflammatory Responses. Contrib Microbiol. 2011; 17:1-11.]Search in Google Scholar
[2. James D. Faix. Biomarkers of sepsis. Crit Rev Clin Lab Sci. Jan 2013;23-36.10.3109/10408363.2013.764490361396223480440]Search in Google Scholar
[3. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med Feb 2013; 41:580-637. DOI: 10.1097/CCM.0b013e31827e83af.10.1097/CCM.0b013e31827e83af23353941]Search in Google Scholar
[4. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6.10.1097/01.CCM.0000050454.01978.3B12682500]Search in Google Scholar
[5. Romualdo LG, Torrella PE, González MV, Sánchez RJ, Holgado AH, Freire AO, et al. Diagnostic accuracy of presepsin (soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the Emergency Department. Clin Biochem Dec, 2014; 47:505-8. DOI: 10.1016/j.clinbiochem.2014.02.011.10.1016/j.clinbiochem.2014.02.01124560955]Search in Google Scholar
[6. Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother. May, 2011;66:33-40. DOI: 10.1093/jac/dkq523.10.1093/jac/dkq52321398306]Search in Google Scholar
[7. Kopterides P, Tsangaris I. Procalcitonin and sepsis: recent data on diagnostic utility prognostic potential and therapeutic implications in critically ill patients. Minerva Anestesiol. Jul 2012;78:823-835.]Search in Google Scholar
[8. Sridharan P, Chamberlain RS. The efficacy of procalcitonin as a biomarker in the management of sepsis: slaying dragons or tilting at windmills? Surg Infect (Larchmt). 2013; 14:489-511. DOI: 10.1089/ sur.2012.028.10.1089/sur.2012.02824274059]Search in Google Scholar
[9. Gucyetmez B, Atalan HK. C - reactive protein and Hemogram Parameters for the Non-Sepsis Systemic Inflammatory Response Syndrome and Sepsis: What Do They Mean? PLoS One. 2016; 11:e0148699. DOI: 10.1371/journal.pone.0148699.10.1371/journal.pone.0148699474922826863002]Search in Google Scholar
[10. Zou Q1, Wen W1, Zhang XC. Presepsin as a novel sepsis biomarker. World J Emerg Med. 2014;5(1):16-9. DOI: 10.5847/wjem.j.issn.1920-8642.2014.01.002.10.5847/wjem.j.issn.1920-8642.2014.01.002412985725215141]Search in Google Scholar
[11. Behnes M, Bertsch T, Lepiorz D, Lang S, Trinkmann F, Brueckmann M, et al. Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment. Crit Care. 2014;18(5):507. DOI: 10.1186/ s13054-014-0507-z.10.1186/s13054-014-0507-z417428325190134]Search in Google Scholar
[12. Biron BM, Ayala A, Lomas-Neira JL Biomarkers for Sepsis: What Is and What Might Be? Biomark Insights. 2015;10(4):7-17.]Search in Google Scholar
[13. Belloni D, Marcatti M, Ponzoni M, et al. Angiopoietin-2 in bone marrow milieu promotes multiple myeloma- associated angiogenesis. Exp Cell Res. Sep 2015;330(1):1-12. DOI: 10.1016/j.yexcr.2014.10.017.10.1016/j.yexcr.2014.10.01725447443]Search in Google Scholar
[14. Elhefny RA, Shaban MM, Shaker OG. Prognostic value of pro-inflammatory cytokine and pro-angiogenesis factor in differentiating malignant from benign exudative effusion. Clin Respir J. May, 2015. DOI: 10.1111/ crj.12302.10.1111/crj.12302]Search in Google Scholar
[15. Milam KE, Parikh SM. The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation. Tissue Barriers. 2014; 3:1-2.]Search in Google Scholar
[16. Scholz A, Plate KH, Reiss Y. Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation. Ann N Y Acad Sci. 2015;1347:45-51. DOI: 10.1111/nyas.12726.10.1111/nyas.1272625773744]Search in Google Scholar
[17. Szederjesi J, Almasy E, Lazar A, Huțanu A, Georgescu AM. The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis. J Crit Care Med. Jan 2015;1(1):18-23. DOI: 10.1515/jccm-2015-0004.10.1515/jccm-2015-0004595328029967811]Search in Google Scholar
[18. Kümpers P, Lukasz A, David S, Horn R, Hafer C, Faulhaber-Walter R, et al. Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care.May, 2008;12(6):R147. DOI: 10.1186/cc7130.10.1186/cc7130264631019025590]Search in Google Scholar
[19. Giuliano JS Jr, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, et al. Admission angiopoietin levels in children with septic shock. Shock. May, 2007;28:650-4. DOI: 10.1097/shk.0b013e318123867b.10.1097/shk.0b013e318123867b]Search in Google Scholar
[20. Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock. 2009 Apr;31(4):348-53. DOI: 10.1097/ SHK.0b013e318188bd06.10.1097/SHK.0b013e318188bd0618791490]Search in Google Scholar
[21. Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, et al. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit Care Med. 2007Jan; 35(1):199-206. DOI: 10.1097/01.CCM.0000251640.77679.D7.10.1097/01.CCM.0000251640.77679.D717110873]Search in Google Scholar
[22. David S, Kümpers P, Lukasz A, Fliser D, Martens- Lobenhoffer J, Bode-Böger SM, et al. Circulating angiopoietin-2 levels increase with progress of chronic kidney disease. Nephrol Dial Transplant. Aug, 2010;25:2571-6. DOI: 10.1093/ndt/gfq060.10.1093/ndt/gfq06020179005]Search in Google Scholar
[23. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006 Feb;34(2):344-53. DOI: 10.1097/01.CCM.0000194725.48928.3A.10.1097/01.CCM.0000194725.48928.3A16424713]Search in Google Scholar
[24. Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-54. DOI: 10.1056/NEJMoa022139.10.1056/NEJMoa02213912700374]Search in Google Scholar
[25. Phua J, Ngerng W, See K, Tay C, Kiong T, Lim H, et al. Characteristics and outcomes of culture-negative versus culture-positive severe sepsis. Crit Care. 2013 Sep 12;17(5):R202. DOI: 10.1186/cc12896.10.1186/cc12896405741624028771]Search in Google Scholar
[26. Nicolas de Prost, Keyvan Razazi, and Christian Brun- Buisson Unrevealing culture-negative severe sepsis. Crit Care. Sep, 2013; 17(5): 1001 DOI: 10.1186/ cc13022.10.1186/cc13022405635924074289]Search in Google Scholar
[27. De Busk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC. Tie-2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. Sep 2003;48(9):2461-71. DOI: 10.1002/art.11213.10.1002/art.1121313130465]Search in Google Scholar
[28. Nadar SK, Blann A, Beevers DG, Lip GY. Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]. J Intern Med. Oct 2005;258(4):336-43. DOI: 10.1111/j.1365-2796.2005.01550.x.10.1111/j.1365-2796.2005.01550.x16164572]Search in Google Scholar
[29. Schröder J, Staubach KH, Zabel P, Stüber F, Kremer B. Procalcitonin as a marker of severity in septic shock. Langenbecks Arch Surg. Feb 1999;384(1):33-8. DOI: 10.1007/s004230050170.10.1007/s00423005017010367627]Search in Google Scholar
[30. Samraj RS, Zingarelli B, Wong HR. Role of biomarkers in sepsis care. Shock. Nov 2013;40(5):358-65. DOI: 10.1097/SHK.0b013e3182a66bd6.10.1097/SHK.0b013e3182a66bd6380604724088989]Search in Google Scholar
[31. Koenig SM, Truwit JD. Ventilator-Associated Pneumonia: diagnosis, treatment, and prevention. Clin Microbiol Rev. Oct 2006;19(4):637-57. DOI: 10.1128/ CMR.00051-05.10.1128/CMR.00051-05159269417041138]Search in Google Scholar
[32. Michetti CP, Fakhry SM, Ferguson PL, Cook A, Moore FO, Gross R. Ventilator-associated pneumonia rates at major trauma centers compared with a national benchmark: a multi-institutional study of the AAST. J Trauma Acute Care Surg. May 2012;72(5):1165-73. DOI: 10.1097/TA.0b013e31824d10fa.10.1097/TA.0b013e31824d10fa22673241]Search in Google Scholar
[33. Cook D. Ventilator associated pneumonia: perspectives on the burden of illness. Intensive Care Med. Apr, 2000;26(1):31-7. DOI: 10.1007/s001340051116.10.1007/s00134005111610786956]Search in Google Scholar
[34. Aslan A, Jongman RM, Moser J, Stegeman CA, van Goor H, Diepstra A, et al. The renal angiopoietin/ Tie-2 system in lethal human sepsis, Crit Care. Mar 2014;18(2):423. DOI: 10.1186/cc13806.10.1186/cc13806405707424976393]Search in Google Scholar
[35. Alves BE, Montalvao SA, Aranha FJ, Siegl TF, Souza CA, Lorand-Metze I, et al. Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia. BMC Infect Dis. May 2010;10:143. DOI: 10.1186/1471-2334-10-143.10.1186/1471-2334-10-143289000420509945]Search in Google Scholar
[36. De Azevedo JR, Torres OJ, Beraldi RA, Ribas CA, Malafaia O. Prognostic evaluation of severe sepsis and septic shock: procalcitonin clearance vs Δ Sequential Organ Failure Assessment. J Crit Care. 2015; 30(1):219. DOI: 10.1016/j.jcrc.2014.08.018.10.1016/j.jcrc.2014.08.01825241933]Search in Google Scholar
[37. American College of Chest Physicians/Society of Critical Care Medicine, Consensus Conference, Crit Care Med 1992 Jun;20(6):864-74.10.1097/00003246-199206000-00025]Search in Google Scholar