<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.</p></abstract>

Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.

Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

“Colentina” Clinical Hospital, Department of Pathology, Bucharest, Romania

“Carol Davila” University of Medicine, Bucharest, Romania

“Colentina” Clinical Hospital, Department of Gastroenterology, Bucharest, Romania

“Spiru Haret” University, Bucharest, Romania

“Ştefan S. Nicolau” Institute of Virology, Bucharest, Romania

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor...

Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

Published Online: May 20, 2016

Page range: 113 - 120

Received: Nov 08, 2015

DOI: https://doi.org/10.1515/rjim-2016-0016

Keywords
gastric cancer, mast cells, tryptase, new vessel density, Helicobacter pylori infection

© 2016 Gianina Viorica Micu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

Published Online: May 20, 2016

Page range: 113 - 120

Received: Nov 08, 2015

DOI: https://doi.org/10.1515/rjim-2016-0016

Keywordsgastric cancer, mast cells, tryptase, new vessel density, Helicobacter pylori infection

© 2016 Gianina Viorica Micu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
gastric cancer, mast cells, tryptase, new vessel density, Helicobacter pylori infection