VEGF expression in pancreatic cancer and other malignancies: a review of the literature

1. HOEBEN A., LANDUYT B., HIGHLEY M.S., WILDIERS H., VAN OOSTEROM A.T., DE BRUIJN E.A. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev. 2004; 56(4):549-580.10.1124/pr.56.4.3Search in Google Scholar

2. CRIVELLATO E.The role of angiogenic growth factors in organogenesis. Int J Dev Biol. 2011; 55(4-5):365-75.10.1387/ijdb.103214ecSearch in Google Scholar

3. GERHARDT H.. VEGF and endothelial guidance in angiogenic sprouting. Organogenesis. 2008; 4: 241-246.10.4161/org.4.4.7414Search in Google Scholar

4. TAKAHASHI H., SHIBUYA M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond). 2005 Sep; 109(3):227-41.10.1042/CS20040370Search in Google Scholar

5. TISCHER E., GOSPODAROWICZ D., MITCHELL R., SILVA M., SCHILLING J., LAU K., CRISP T., FIDDES J.C., ABRAHAM J.A. Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family. Biochem Biophys Res Commun. 1989 Dec 29; 165(3):1198-1206.10.1016/0006-291X(89)92729-0Search in Google Scholar

6. TAMMELA T., ENHOLM B., ALITALO K. AND PAAVONEN K. The biology of vascular endothelial growth factors. Cardiovas Res. 2005; 65: 550-563.10.1016/j.cardiores.2004.12.00215664381Search in Google Scholar

7. DELGHANIAN F., HOJATI Z., KAY M. New insights into VEGF-A alternative splicing: Key regulatory switching in pathological process. Avicenna J Med Biotechnol. 2014 Oct; 6(4):192-9.Search in Google Scholar

8. GIACCA M. Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA. Transcription 2010; 1(3):149-153.10.4161/trns.1.3.13229302357621326890Search in Google Scholar

9. NEUFELD G., COHEN T., GENGRINOVITCH S., AND POLTORAK Z.Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13:9-22.10.1096/fasebj.13.1.9Search in Google Scholar

10. POLTORAK Z., COHEN T., SIVAN R., KANDELIS Y., SPIRA G., VLODAVSKY I., KESHET E., AND NEUFELD G. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 1997; 272:7151-7158.10.1074/jbc.272.11.71519054410Search in Google Scholar

11. LEUNG D.W., CACHIANES G., KUANGW. J., GOEDDEL D. V. and FERRARA N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246, 1306-1309.10.1126/science.24799862479986Search in Google Scholar

12. KECK P. J., HAUSER S. D., KRIVI G. ET AL. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989; 246, 1309-1312.Search in Google Scholar

13. CONNOLLY, D. T., HEUVELMAN, D. M., NELSON, R. et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest. 1989; 84, 1470-1478.Search in Google Scholar

14. FERRARA N. AND HENZEL W. J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 1989; 161, 851-858.Search in Google Scholar

15. KAJDANIUK D., MAREK B., BORGIEL-MAREK H., KOS-KUDLA B. Vascular endothelial growth factor (VEGF) part 1: in physiology and pathophysiology. Endokrynol Pol 2011; 62(5):444-455.Search in Google Scholar

16. OLOFSSON, B., JELTSCH, M., ERIKSSON, U. AND ALITALO, K. Current biology of VEGF-B and VEGF-C. Curr. Opin. Biotechnol. 1999; 10, 528-535.Search in Google Scholar

17. ORTEGA N., HUTCHINGS H., AND PLOUET J. Signal relays in the VEGF system. Front Biosci 1999; 4:141-152.Search in Google Scholar

18. WALTENBERGER J, CLAESSON-WELSH L, SIEGBAHN A, SHIBUYA M, and HELDIN CH Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 1994; 269:26988-26995.10.1016/S0021-9258(18)47116-5Search in Google Scholar

19. NAGY J. A., VASILE E., FENG D. et al. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J. Exp. Med. 2002;196, 1497-1506.Search in Google Scholar

20. ACHEN M.G., JELTSCH M., KUKK E., MAKINEN T., VITALI A., WILKS A.F., ALITALO K., AND STACKER S.A. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc NatlAcad Sci USA. 1999;95:548–55310.1073/pnas.95.2.548184579435229Search in Google Scholar

21. ZARKADA G., HEINOLAINEN K., MAKINEN T., KUBOTA Y., ALITALO K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):761-6.10.1073/pnas.1423278112431185925561555Search in Google Scholar

22. FUKUMURA, D., XAVIER, R., SUGIURA, T. et al. Tumor induction of VEGF promoter activity in stromal cells. Cell. 1998; 94, 715-725.Search in Google Scholar

23. ZANG J., LI C., ZHAO L.N., SHI M., ZHOU Y.C., WANG J.H., LI X. Prognostic value of vascular endothelial growth factor in patients with head and neck cancer: A meta-analysis. Head Neck. 2013 Oct; 35(10):1507-14.10.1002/hed.2315622987573Search in Google Scholar

24. ANDISHEH-TADBIR A., HAMZAVI M., REZVANI G., ASHRAF M.J., FATTAHI M.J., KHADEMI B., KAMALI F. Tissue expression, serum and salivary levels of vascular endothelial growth factor in patients with HNSCC. Braz J Otorhinolaryngol. 2014 Nov-Dec; 80(6):503-7.10.1016/j.bjorl.2014.03.00125457070Search in Google Scholar

25. LUO H., LI J., YANG T., WANG J. Expression and significance of VEGF-C and VEGF-D in differentiated thyroid carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun; 23(12):531-4.Search in Google Scholar

26. LIU S.G., YUAN S.H., WU H.Y., LIU J., HUANG C.S. The Clinical Research of Serum VEGF, TGF-β1, and Endostatin in Non-small Cell Lung Cancer. Cell Biochem Biophys. 2014 Dec 30. [Epub ahead of print]10.1007/s12013-014-0431-525548002Search in Google Scholar

27. FU Z.Z., SUN X.D., LI P., ZHANG Z., LI G.Z., GU T., SHAO S.S. Relationship between serum VEGF level and radiosensitivity of patients with nonsmall cell lung cancer among asians: a meta-analysis. DNA Cell Biol. 2014 Jul; 33(7):426-37.10.1089/dna.2013.224924628278Search in Google Scholar

28. LIU G., XU S., JIAO F., REN T., LI Q. Vascular endothelial growth factor B coordinates metastasis of non-small cell lung cancer. Tumour Biol. 2015 Mar; 36(3):2185-9110.1007/s13277-014-2829-525424698Search in Google Scholar

29. JIANG H., SHAO W., ZHAO W. VEGF-C in non-small cell lung cancer: meta-analysis. Clin Chim Acta. 2014 Jan 1; 427:94-9.10.1016/j.cca.2013.10.00224144865Search in Google Scholar

30. SRABOVIC N., MUJAGIC Z., MUJANOVIC-MUSTEDANAGIC J., SOFTIC A., MUMINOVIC Z., RIFATBEGOVIC A., BEGIC L. Vascular endothelial growth factor receptor-1 expression in breast cancer and its correlation to vascular endothelial growth factor A.Int J Breast Cancer. 2013; 2013:746-749.10.1155/2013/746749387667724416596Search in Google Scholar

31. ZHANG F., LI C., LIU H., WANG Y., CHEN Y., WU X. The functional proteomics analysis of VEGF-treated human epithelial ovarian cancer cells. Tumour Biol. 2014 Dec; 35(12):12379-87.10.1007/s13277-014-2552-225192722Search in Google Scholar

32. WANG H., HUANG X., ZHANG J., SHAO N., CHEN L.O., MA D., JI C. The expression of VEGF and Dll4/Notch pathway molecules in ovarian cancer. Clin Chim Acta. 2014 Sep 25; 436:243-8.10.1016/j.cca.2014.06.00524949865Search in Google Scholar

33. WIMBERGER P., CHEBOUTI I., KASIMIR-BAUER S., LACHMANN R., KUHLISCH E., KIMMIG R., SÜLEYMAN E., KUHLMANN J.D. Explorative investigation of vascular endothelial growth factor receptor expression in primary ovarian cancer and its clinical relevance. Gynecol Oncol. 2014 Jun; 133(3):467-72.10.1016/j.ygyno.2014.03.57424713547Search in Google Scholar

34. MANDIC A., USAJ KNEZEVIC S., KAPICL IVKOVIC T. Tissue expression of VEGF in cervical intraepithelial neoplasia and cervical cancer. J BUON. 2014 Oct-Dec; 19(4):958-64.Search in Google Scholar

35. DEMEI M., XIANGXIN L., YONGPING X., YONGXIA Y., YUNHAI Y., LIN Z. Vascular endothelial growth factor C expression is closely correlated with lymph node recurrence and poor prognosis in patients with early stage cervical cancer. J Int Med Res. 2013 Oct; 41(5):1541-9.10.1177/030006051349303823963849Search in Google Scholar

36. WANG J., TAYLOR A., SHOWEIL R., TRIVEDI P., HORIMOTO Y., BAGWAN I., EWINGTON L., LAM E.W., EL-BAHRAWY M.A. Expression profiling and significance of VEGF-A, VEGFR2, VEGFR3 and related proteins in endometrial carcinoma. Cytokine. 2014 Aug; 68(2):94-100.10.1016/j.cyto.2014.04.00524845798Search in Google Scholar

37. ZHUANG Y., WEI M. Impact of vascular endothelial growth factor expression on overall survival in patients with osteosarcoma: a meta-analysis. Tumour Biol. 2014 Mar; 35(3):1745-9.10.1007/s13277-014-1692-824515658Search in Google Scholar

38. YU X.W., WU T.Y., YI X., REN W.P., ZHOU Z.B., SUN Y.Q., ZHANG C.Q. Prognostic significance of VEGF expression in osteosarcoma: a meta-analysis. Tumour Biol. 2014 Jan; 35(1):155-60.10.1007/s13277-013-1019-123907576Search in Google Scholar

39. WOOLLARD D.J., OPESKIN K., COSO S., WU D., BALDWIN M.E., WILLIAMS E.D. Differential expression of VEGF ligands and receptors in prostate cancer.Prostate. 2013 May; 73(6):563-72.10.1002/pros.2259623038639Search in Google Scholar

40. KOPPARAPU P.K., BOORJIAN S.A., ROBINSON B.D., DOWNES M., GUDAS L.J., MONGAN N.P., PERSSON J.L. Expression of VEGF and its receptors VEGFR1/VEGFR2 is associated with invasiveness of bladder cancer.Anticancer Res. 2013 Jun; 33(6):2381-90.Search in Google Scholar

41. SUI L., LIU K., SHEN W., ZHANG L. Relationships between VEGF protein expression and pathological characteristics of diffuse large B cell lymphoma: a meta-analysis. Tumour Biol. 2014 Sep; 35(9):9085-93.10.1007/s13277-014-2173-924913710Search in Google Scholar

42. KINOSHITA S., KASE S., ANDO R., DONG Z., FUKUHARA J., DONG Y., INAFUKU S., NODA K., NODA M., KANDA A., ISHIDA S. Expression of vascular endothelial growth factor in human ocular adnexal lymphoma. Invest Ophthalmol Vis Sci. 2014 May 13; 55(6):3461-7.10.1167/iovs.13-1351024825110Search in Google Scholar

43. ZHANG Y.H., DIAO L., YANG Q., DUO J., LIU Y.X., LIU S.X., YAO X. Expression of VEGFR-2 and VEGFR-3 in papillary renal cell carcinoma and their relationship with prognosis. Zhonghua Zhong Liu Za Zhi. 2010 Oct; 32(10):752-6.Search in Google Scholar

44. ZHAO S.F., YANG X.D., LU M.X., SUN G.W., WANG Y.X., ZHANG Y.K., PU Y.M., TANG E.Y. Prognostic significance of VEGF immunohistochemical expression in oral cancer: a meta-analysis of the literature. Tumour Biol. 2013 Oct; 34(5):3165-71.10.1007/s13277-013-0886-923737289Search in Google Scholar

45. YANASE M., KATO K., YOSHIZAWA K., NOGUCHI N., KITAHARA H., NAKAMURA H. Prognostic value of vascular endothelial growth factors A and C in oral squamous cell carcinoma. J Oral Pathol Med. 2014 Aug; 43(7):514-20.10.1111/jop.1216724762199Search in Google Scholar

46. AGGARWAL S., DEVARAJA K., SHARMA S.C., DAS S.N. Expression of vascular endothelial growth factor (VEGF) in patients with oral squamous cell carcinoma and its clinical significance. Clin Chim Acta. 2014 Sep 25; 436:35-40.10.1016/j.cca.2014.04.02724833243Search in Google Scholar

47. LI J.D., LIANG R.Y., ZHAO Y.P., XU Y.L. Correlation analysis of VEGF and PTEN expression in gingival carcinoma. Shanghai Kou Qiang Yi Xue. 2014 Oct; 23(5):619-23.Search in Google Scholar

48. OMOTO I., MATSUMOTO M., OKUMURA H., UCHIKADO Y., SETOYAMA T., KITA Y., OWAKI T., KIJIMA Y., SHINCHI H., ISHIGAMI S., UENO S., NATSUGOE S. Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma. Oncol Lett. 2014 Apr; 7(4):1027-1032.10.3892/ol.2014.1823396129024944663Search in Google Scholar

49. Yang Z, Wang YG, Su K. VEGF-C and VEGF-D expression and its correlation with lymph node metastasis in esophageal squamous cell cancer tissue. Asian Pac J Cancer Prev. 2015; 16(1):271-4.10.7314/APJCP.2015.16.1.271Search in Google Scholar

50. SU C.M., SU Y.H., CHIU C.F., CHANG Y.W., HONG CC, YU Y.H., HO Y.S., WU C.H., YEN C.S., SU J.L. Vascular endothelial growth factor-C upregulates cortactin and promotes metastasis of esophageal squamous cell carcinoma. Ann Surg Oncol. 2014 Dec; 21 Suppl 4:S767-75.10.1245/s10434-014-4009-725212831Search in Google Scholar

51. XU X.L., LING Z.Q., CHEN W., XU Y.P., MAO W.M. The overexpression of VEGF in esophageal cancer is associated with a more advanced TMN stage: a meta-analysis. Cancer Biomark. 2013;13(2):105-13.10.3233/CBM-13034323838139Search in Google Scholar

52. HOU X., WEI J.C., FU J.H., WANG X., LUO R.Z., HE J.H., ZHANG L.J., LIN P., YANG H.X. Vascular Endothelial Growth Factor is a Useful Predictor of Postoperative Distant Metastasis and Survival Prognosis in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2015 Feb 5 [Epub ahead of print].10.1245/s10434-015-4390-x25652047Search in Google Scholar

53. BLANK S., DECK C., DREIKHAUSEN L., WEICHERT W., GIESE N., FALK C., SCHMIDT T., OTT K. Angiogenic and growth factors in gastric cancer. J Surg Res. 2015 Apr; 194(2):420-9.10.1016/j.jss.2014.11.02825577146Search in Google Scholar

54. WANG L., LI H.G., WEN J.M., PENG T.S., ZENG H., WANG L.Y. Expression of CD44v3, erythropoietin and VEGF-C in gastric adenocarcinomas: correlations with clinicopathological features. Tumori. 2014 May-Jun; 100(3):321-7.10.1177/1578.17216Search in Google Scholar

55. CAO W., FAN R., YANG W., WU Y. VEGF-C expression is associated with the poor survival in gastric cancer tissue. Tumour Biol. 2014 Apr; 35(4):3377-83.10.1007/s13277-013-1445-0Search in Google Scholar

56. PENG L., ZHAN P., ZHOU Y., FANG W., ZHAO P., ZHENG Y., XU N. Prognostic significance of vascular endothelial growth factor immunohistochemical expression in gastric cancer: a meta-analysis. Mol Biol Rep. 2012 Oct; 39(10):9473-84.10.1007/s11033-012-1812-8Search in Google Scholar

57. JI Y.N., WANG Q., LI Y., WANG Z. Prognostic value of vascular endothelial growth factor A expression in gastric cancer: a meta-analysis.Tumour Biol. 2014 Mar; 35(3):2787-93.10.1007/s13277-013-1371-1Search in Google Scholar

58. WANG Y., YAO X., GE J., HU F., ZHAO Y. Can vascular endothelial growth factor and microvessel density be used as prognostic biomarkers for colorectal cancer? A systematic review and meta-analysis. ScientificWorld Journal. 2014; 2014:102736.10.1155/2014/102736Search in Google Scholar

59. BEŞTAŞ R., KAPLAN M.A., IŞIKDOĞAN A. The correlation between serum VEGF levels and known prognostic risk factors in colorectal carcinoma.Hepatogastroenterology. 2014 Mar-Apr; 61(130):267-71.Search in Google Scholar

60. ARAÚJO R.F. JR, LIRA G.A., VILAÇA J.A., GUEDES H.G., LEITÃO M.C., LUCENA H.F., RAMOS C.C. Prognostic and diagnostic implications of MMP-2, MMP-9, and VEGF-α expressions in colorectal cancer. Pathol Res Pract. 2015 Jan; 211(1):71-7.10.1016/j.prp.2014.09.007Search in Google Scholar

61. GOOS J.A., DE CUBA E.M., COUPÉ V.M., DIOSDADO B., DELIS-VAN DIEMEN P.M., KARGA C., BELIËN J.A., MENKE-VAN DER HOUVEN VAN OORDT C.W., GELDOF A.A., MEIJER G.A., HOEKSTRA O.S., FIJNEMAN R.J.; THE DECODE PET GROUP. Glucose transporter 1 (SLC2A1) and vascular endothelial growth factor A (VEGFA) predict survival after resection of colorectal cancer liver metastasis. Ann Surg. 2015 Jan 5. [Epub ahead of print]10.1097/SLA.0000000000001109Search in Google Scholar

62. XU C.J., XU F. MMP-11 and VEGF-C expression correlate with clinical features of colorectal adenocarcinoma. Int J Clin Exp Med. 2014 Sep 15; 7(9):2883-8.Search in Google Scholar

63. MARTINS S.F., GARCIA E.A., LUZ M.A., PARDAL F., RODRIGUES M., FILHO A.L. Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer.Cancer Genomics Proteomics. 2013 Mar-Apr; 10(2):55-67.Search in Google Scholar

64. HSIEH M.C., HSU H.T., HSIAO P.C., YANG S.F., YEH C.B., BIEN M.Y., LIN C.H., CHIEN M.H. Role of VEGF-C gene polymorphisms in susceptibility to hepatocellular carcinoma and its pathological development.J Clin Lab Anal. 2014 May; 28(3):237-44.10.1002/jcla.21672Search in Google Scholar

65. LETELIER P., GARCIA P., LEAL P., ILI C., BUCHEGGER K., RIQUELME I., SANDOVAL A., TAPIA O., ROA J.C. Immunohistochemical expression of vascular endothelial growth factor A in advanced gallbladder carcinoma. Appl Immunohistochem Mol Morphol. 2014 Aug; 22(7):530-6.10.1097/PAI.0b013e3182a318a9Search in Google Scholar

66. LIN W., JIANG L., CHEN Y., SHE F., HAN S., ZHU J., ZHOU L., TANG N., WANG X., LI X. Vascular endothelial growth factor-D promotes growth, lymphangiogenesis and lymphatic metastasis in gallbladder cancer. Cancer Lett. 2012 Jan 28; 314(2):127-36.10.1016/j.canlet.2011.09.004Search in Google Scholar

67. SIPOS B., KLAPPER W., KRUSE M.L., KALTHOFF H., KERJASCHKI D., KLÖPPEL G. Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors. Am J Pathol. 2004 Oct; 165(4):1187-97.10.1016/S0002-9440(10)63379-2Search in Google Scholar

68. HANSEL D.E., RAHMAN A., HERMANS J., DE KRIJGER R.R., ASHFAQ R., YEO C.J., CAMERON J.L., MAITRA A. Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression. Mod Pathol. 2003 Jul; 16(7):652-9.10.1097/01.MP.0000077416.68489.50Search in Google Scholar

69. REID M.D., CHOI H., BALCI S., AKKAS G., ADSAY V. Serous cystic neoplasms of the pancreas: clinicopathologic and molecular characteristics. Semin Diagn Pathol. 2014 Nov; 31(6):475-83.10.1053/j.semdp.2014.08.009Search in Google Scholar

70. YIP-SCHNEIDER M.T., WU H., DUMAS R.P. HANCOCK B.A., AGARAM N., RADOVICH M., SCHMIDT C.M. Vascular endothelial growth factor, a novel and highly accurate pancreatic fluid biomarker for serous pancreatic cysts. J Am Coll Surg. 2014 Apr; 218(4):608-17.10.1016/j.jamcollsurg.2013.12.019Search in Google Scholar

71. LISZKA Ł., PAJĄK J., GOŁKA D. Serous neoplasms of the pancreas share many, but not all aspects of their microvascular and angiogenic profile with low-grade clear cell renal cell carcinomas. Pathol Res Pract. 2014 Dec; 210(12):901-8.10.1016/j.prp.2014.06.033Search in Google Scholar

72. AI K.X., LU L.Y., HUANG X.Y., CHEN W., ZHANG H.Z. Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer.World J Gastroenterol. 2008 Mar 28; 14(12):1931-5.10.3748/wjg.14.1931Search in Google Scholar

73. VON MARSCHALL Z., CRAMER T., HÖCKER M., BURDE R., PLATH T., SCHIRNER M., HEIDENREICH R., BREIER G., RIECKEN E.O., WIEDENMANN B., ROSEWICZ S. De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop. Gastroenterology. 2000 Nov; 119(5):1358-72.10.1053/gast.2000.19578Search in Google Scholar

74. SEO Y., BABA H., FUKUDA T., TAKASHIMA M., SUGIMACHI K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer. 2000 May 15; 88(10):2239-45.10.1002/(SICI)1097-0142(20000515)88:10<2239::AID-CNCR6>3.0.CO;2-VSearch in Google Scholar

75. LIANG Q.L., WANG B.R., CHEN G.Q., LI G.H., XU Y.Y. Clinical significance of vascular endothelial growth factor and connexin43 for predicting pancreatic cancerclinicopathologic parameters. Med Oncol. 2010 Dec; 27(4):1164-70.10.1007/s12032-009-9354-1Search in Google Scholar

76. ZORGETTO V.A., SILVEIRA G.G., OLIVEIRA-COSTA J.P., SOAVE D.F., SOARES F.A., RIBEIRO-SILVA A. The relationship between lymphatic vascular density and vascular endothelial growth factor A (VEGF-A)expression with clinical-pathological features and survival in pancreatic adenocarcinomas. Diagn Pathol. 2013 Oct 18; 8:170.10.1186/1746-1596-8-170Search in Google Scholar

77. GEORGIADOU D., SERGENTANIS T.N., SAKELLARIOU S., FILIPPAKIS G.M., ZAGOURI F., VLACHODIMITROPOULOS D., PSALTOPOULOU T., LAZARIS A.C., PATSOURIS E., ZOGRAFOS G.C.VEGF and Id-1 in pancreatic adenocarcinoma: prognostic significance and impact on angiogenesis. Eur J Surg Oncol. 2014 Oct; 40(10):1331-7.10.1016/j.ejso.2014.01.004Search in Google Scholar

78. SMITH R.A., TANG J., TUDUR-SMITH C., NEOPTOLEMOS J.P., GHANEH P. Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. Br J Cancer. 2011 Apr 26; 104(9):1440-51.10.1038/bjc.2011.110310192821448172Search in Google Scholar

79. PATSOURAS D., PAPAXOINIS K., KOSTAKIS A., SAFIOLEAS M.C., LAZARIS A.C., NICOLOPOULOU-STAMATI P. Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Mol Med Rep. 2015 Jun; 11(6):4585-9010.3892/mmr.2015.325925625587Search in Google Scholar

80. SIPOS B., WEBER D., UNGEFROREN H., KALTHOFF H., ZÜHLSDORFF A., LUTHER C., TÖRÖK V., KLÖPPEL G. Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study. Int J Cancer. 2002 Dec 20; 102(6):592-600.10.1002/ijc.1075312448000Search in Google Scholar

81. ANDREOZZI M., QUAGLIATA L., GSPONER J.R., RUIZ C., VUAROQUEAUX V., EPPENBERGER-CASTORI S., TORNILLO L., TERRACCIANO L.M. VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities. Angiogenesis. 2014 Jul; 17(3):519-27.10.1007/s10456-013-9396-z24114200Search in Google Scholar

82. TANG R.F., WANG S.X., PENG L., WANG S.X., ZHANG M., LI Z.F., ZHANG Z.M., XIAO Y., ZHANG F.R. Expression of vascular endothelial growth factors A and C in human pancreatic cancer.World J Gastroenterol. 2006 Jan 14; 12(2):280-6.10.3748/wjg.v12.i2.280406603916482630Search in Google Scholar

83. DOI Y., YASHIRO M., YAMADA N., AMANO R., NODA S., HIRAKAWA K. VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. Ann Surg Oncol. 2012 Aug; 19(8):2733-43.10.1245/s10434-011-2181-622207048Search in Google Scholar

84. DOI Y., YASHIRO M., YAMADA N., AMANO R., OHIRA G., KOMOTO M., NODA S., KASHIWAGI S., KATO Y., FUYUHIRO Y., HIRAKAWA K. Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer. Cancer Sci. 2010 Jun; 101(6):1529-35.10.1111/j.1349-7006.2010.01547.x20367641Search in Google Scholar

85. KNOLL M.R., RUDNITZKI D., STURM J., MANEGOLD B.C., POST S., JAEGER T.M. Correlation of postoperative survival and angiogenic growth factors in pancreatic carcinoma. Hepatogastroenterology. 2001 Jul-Aug; 48(40):1162-5.Search in Google Scholar

86. TANG R.F., ITAKURA J., AIKAWA T., MATSUDA K., FUJII H., KORC M., MATSUMOTO Y. Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer. Pancreas. 2001 Apr; 22(3):285-92.10.1097/00006676-200104000-0001011291931Search in Google Scholar

87. SCHNEIDER M., BÜCHLER P., GIESE N., GIESE T., WILTING J., BÜCHLER M.W., FRIESS H. Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread. Int J Oncol. 2006 Apr; 28(4):883-90.10.3892/ijo.28.4.883Search in Google Scholar

88. CHENG P., JIN G., HU X., SHI M., ZHANG Y., LIU R., ZHOU Y., SHAO C., ZHENG J., ZHU M. Analysis of tumor-induced lymphangiogenesis and lymphatic vessel invasion of pancreatic carcinoma in the peripheral nerve plexus. Cancer Sci. 2012 Oct; 103(10):1756-63.10.1111/j.1349-7006.2012.02364.x765926622716017Search in Google Scholar

89. LI K., LI M.J., HE T., ZHENG Z., ZHENG X.L., QU B.H., WANG Y., DUAN X., ZHENG Y.J. Expression of vascular endothelial growth factor C in pancreatic cancer and its effect upon lymph node metastasis. Zhonghua Yi Xue Za Zhi. 2009 Sep 15; 89(34):2386-90.Search in Google Scholar

90. VON MARSCHALL Z., SCHOLZ A., STACKER S.A., ACHEN M.G., JACKSON D.G., ALVES F., SCHIRNER M., HABEREY M., THIERAUCH K.H., WIEDENMANN B., ROSEWICZ S. Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. Int J Oncol. 2005 Sep; 27(3):669-79.Search in Google Scholar

91. KURAHARA H., TAKAO S., MAEMURA K., SHINCHI H., NATSUGOE S., AIKOU T. Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis.Clin Cancer Res. 2004 Dec 15; 10(24):8413-20.10.1158/1078-0432.CCR-04-037915623620Search in Google Scholar

92. WEY J.S., FAN F., GRAY M.J., BAUER T.W., MCCARTY M.F., SOMCIO R., LIU W., EVANS D.B., WU Y., HICKLIN D.J., ELLIS L.M. Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines.Cancer. 2005 Jul 15; 104(2):427-38.10.1002/cncr.2114515952180Search in Google Scholar

93. YANG A.D., CAMP E.R., FAN F., SHEN L., GRAY M.J., LIU W., SOMCIO R., BAUER T.W., WU Y., HICKLIN D.J., ELLIS L.M.. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res. 2006 Jan 1; 66(1):46-51.10.1158/0008-5472.CAN-05-308616397214Search in Google Scholar

94. CHUNG G.G., YOON H.H., ZERKOWSKI M.P., GHOSH S., THOMAS L., HARIGOPAL M., CHARETTE L.A., SALEM R.R., CAMP R.L., RIMM D.L., BURTNESS B.A. Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray.Cancer. 2006 Apr 15; 106(8):1677-84.10.1002/cncr.2178316532435Search in Google Scholar

95. ANGELESCU R., BURADA F., ANGELESCU C., GHEONEA D.I., IORDACHE S., MIXICH F., IOANA M., SĂFTOIU A. Expression of vascular endothelial growth factor and epidermal growth factor receptor in pancreatic ductal adenocarcinomas, neuroendocrine tumours and chronic pancreatitis. Endosc Ultrasound. 2013 Apr; 2(2):86-91.10.4103/2303-9027.117692406225024949370Search in Google Scholar