Voluntary deep inspiration breath-hold reduces the heart dose without compromising the target volume coverage during radiotherapy for left-sided breast cancer
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Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends - an update. Cancer Epidemiol Biomarkers Prev 2016; 25: 16-27. 10.1158/1055-996526667886TorreLASiegelRLWardEMJemalA.Global cancer incidence and mortality rates and trends - an update201625162710.1158/1055-9965Open DOISearch in Google Scholar
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013; 49: 1374-403. 10.1016/j.ejca.2012.12.02723485231FerlayJSteliarova-FoucherELortet-TieulentJRossoSCoeberghJWWComberHCancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012201349137440310.1016/j.ejca.2012.12.027Open DOISearch in Google Scholar
Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005; 366: 2087-106. 10.1016/S0140-6736(05)67887-7.16360786ClarkeMCollinsRDarbySDaviesCElphinstonePEvansVEffects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials2005366208710610.1016/S0140-6736(05)67887-7Open DOISearch in Google Scholar
Fisher B, Anderson S, Bryant J, Margoloese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347: 1233-41. 10.1056/NEJMoa02215212393820FisherBAndersonSBryantJMargoloeseRGDeutschMFisherERTwenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer200234712334110.1056/NEJMoa022152Open DOISearch in Google Scholar
Early Breast Cancer Trialists’ Collaborative Group. Effect of radiotherapy after breast conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011; 378: 1707-16. 10.1016/S0140-6736(11)61629-2Early Breast Cancer Trialists’ Collaborative Group. Effect of radiotherapy after breast conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials201137817071610.1016/S0140-6736(11)61629-2Open DOISearch in Google Scholar
Early Breast Cancer Trialists’ Collaborative Group. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 2014; 383: 2127-35. 10.1016/S0140-6736(14)60488-8Early Breast Cancer Trialists’ Collaborative Group. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials201438321273510.1016/S0140-6736(14)60488-8Open DOISearch in Google Scholar
Danish Breast Cancer Cooperative Group, Nielsen HM, Overgaard M, Grau C, Jensen AR, Overgaard J. Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies. J Clin Oncol 2006; 24: 2268-75. 10.1200/JCO.2005.02.873816618947Danish Breast Cancer Cooperative GroupNielsenHMOvergaardMGrauCJensenAROvergaardJ.Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies20062422687510.1200/JCO.2005.02.873816618947Open DOISearch in Google Scholar
Kanapuru B, Ershler WB, Hesdorffer C, Jemal A, Yates JW. Long-term survival of older breast cancer patients: population-based estimates over three decades. Breast Cancer Res Treat 2012; 134: 853-7. 10.1007/s10549-012-2115-422710707KanapuruBErshlerWBHesdorfferCJemalAYatesJW.Long-term survival of older breast cancer patients: population-based estimates over three decades2012134853710.1007/s10549-012-2115-422710707Open DOISearch in Google Scholar
Taylor CW, Brønnum D, Darby SC, Gagliardi G, Hall P, Jensen MB, et al. Cardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-2001. Radiother Oncol 2011; 100: 176-83. 10.1016/j.radonc.2011.01.02021376412TaylorCWBrønnumDDarbySCGagliardiGHallPJensenMBCardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-200120111001768310.1016/j.radonc.2011.01.020316873321376412Open DOISearch in Google Scholar
Duma MN, Molls M, Trott KR. From heart to heart for breast cancer patients - cardiovascular toxicities in breast cancer radiotherapy. Strahlenther Onkol 2014; 190: 5-7. 10.1007/s00066-013-0465-424253182DumaMNMollsMTrottKR.From heart to heart for breast cancer patients - cardiovascular toxicities in breast cancer radiotherapy20141905710.1007/s00066-013-0465-424253182Open DOISearch in Google Scholar
Carlson RG, Mayfield WR, Normann S, Alexander JA. Radiation-associated valvular disease. Chest 1991; 99: 538-45. http://dx.doi.org/10.1378/chest.99.3.53810.1378/chest.99.3.5381995208CarlsonRGMayfieldWRNormannSAlexanderJA.Radiation-associated valvular disease19919953845http://dx.doi.org/10.1378/chest.99.3.538Open DOISearch in Google Scholar
Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013; 368: 987-98. 10.1056/NEJMoa120982523484825DarbySCEwertzMMcGalePBennetAMBlom-GoldmanUBrønnumDRisk of ischemic heart disease in women after radiotherapy for breast cancer20133689879810.1056/NEJMoa1209825Open DOISearch in Google Scholar
Heidenreich PA, Hancock SL, Vagelos RH, Lee BK, Schnittger I. Diastolic dysfunction after mediastinal irradiation. Am Heart J 2005; 150: 977-82. 10.1016/j.ahj.2004.12.02616290974HeidenreichPAHancockSLVagelosRHLeeBKSchnittgerI.Diastolic dysfunction after mediastinal irradiation20051509778210.1016/j.ahj.2004.12.026Open DOISearch in Google Scholar
Orzan F, Brusca A, Gaita F, Giustetto C, Figliomeni MC, Libero L. Associated cardiac lesions in patients with radiation-induced complete heart block. Int J Cardiol 1993; 39: 151-6. 10.1016/0167-5273(93)90027-E8314649OrzanFBruscaAGaitaFGiustettoCFigliomeniMCLiberoL.Associated cardiac lesions in patients with radiation-induced complete heart block199339151610.1016/0167-5273(93)90027-EOpen DOISearch in Google Scholar
Larsen RL, Jakacki RI, Vetter VL, Meadows AT, Silber JH, Barber G. Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults. Am J Cardiol 1992; 70: 73-7. 10.1016/0002-9149(92)91393-ILarsenRLJakackiRIVetterVLMeadowsATSilberJHBarberG.Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults19927073710.1016/0002-9149(92)91393-IOpen DOISearch in Google Scholar
Giordano SH, Kuo YF, Freeman JL, Buchholz TA, Hortobagy GN, Goodwin JS. Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst 2005; 97: 419-24. 10.1093/jnci/dji06715770005GiordanoSHKuoYFFreemanJLBuchholzTAHortobagyGNGoodwinJS.Risk of cardiac death after adjuvant radiotherapy for breast cancer2005974192410.1093/jnci/dji067Open DOISearch in Google Scholar
Cheng YJ, Nie XY, Ji CC, Lin XX, Liu J, Chen XM, et al. Long-Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer. J Am Heart Assoc 2017; 6: e005633. 10.1161/JAHA.117.00563328529208ChengYJNieXYJiCCLinXXLiuJChenXMLong-Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer20176e00563310.1161/JAHA.117.005633Open DOISearch in Google Scholar
Højris I, Overgaard M, Christensen JJ, Overgaard J. Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group. Lancet 1999; 354: 1425-30. 10.1016/S0140-6736(99)02245-X.10543669HøjrisIOvergaardMChristensenJJOvergaardJ.Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group199935414253010.1016/S0140-6736(99)02245-XOpen DOISearch in Google Scholar
McGale P, Darby SC, Hall P, Adolfsson J, Bengtsson NO, Bennet AM, et al. Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden. Radiother Oncol 2011; 100: 167-75. 10.1016/j.radonc.2011.06.01621752480McGalePDarbySCHallPAdolfssonJBengtssonNOBennetAMIncidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden20111001677510.1016/j.radonc.2011.06.01621752480Open DOISearch in Google Scholar
Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, et al. Estimating the risks of breast cancer radiotherapy: evidence from modern radiation doses to the lungs and heart and from previous randomized trials. J Clin Oncol 2017; 35: 1641-9. 10.1200/JCO.2016.72.072228319436TaylorCCorreaCDuaneFKAznarMCAndersonSJBerghJEstimating the risks of breast cancer radiotherapy: evidence from modern radiation doses to the lungs and heart and from previous randomized trials2017351641910.1200/JCO.2016.72.0722554822628319436Open DOISearch in Google Scholar
Paszat LF, Mackillop WJ, Groome PA, Boyd C, Schulze K, Holowaty E. Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol 1998; 16: 2625-31. 10.1200/JCO.1998.16.8.26259704712PaszatLFMackillopWJGroomePABoydCSchulzeKHolowatyE.Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries19981626253110.1200/JCO.1998.16.8.26259704712Open DOISearch in Google Scholar
Lee MS, Finch W, Mahmud E. Cardiovascular complications of radiotherapy. Am J Cardiol 2013; 112: 1688-96. 10.1016/j.amjcard.2013.07.03124012026LeeMSFinchWMahmudE.Cardiovascular complications of radiotherapy201311216889610.1016/j.amjcard.2013.07.03124012026Open DOISearch in Google Scholar
Correa CR, Litt HI, Hwang WT, Ferrari VA, Solin LJ, Harris EE. Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer. J Clin Oncol 2007; 25: 3031-7. 10.1200/JCO.2006.08.659517634481CorreaCRLittHIHwangWTFerrariVASolinLJHarrisEE.Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer2007253031710.1200/JCO.2006.08.659517634481Open DOISearch in Google Scholar
Stranzl H, Zurl B. Postoperative irradiation of left-sided breast cancer patients and cardiac toxicity. Strahlenther Onkol 2008; 184: 354-8. 10.1007/s00066-008-1852-019016033StranzlHZurlB.Postoperative irradiation of left-sided breast cancer patients and cardiac toxicity2008184354810.1007/s00066-008-1852-019016033Open DOISearch in Google Scholar
Shah C, Badiyan S, Berry S, Khan AJ, Goyal S, Schulte K, et al. Cardiac dose sparing and avoidance techniques in breast cancer radiotherapy. Radiother Oncol 2014; 112: 9-16. 10.1016/j.radonc.2014.04.00924813095ShahCBadiyanSBerrySKhanAJGoyalSSchulteKCardiac dose sparing and avoidance techniques in breast cancer radiotherapy201411291610.1016/j.radonc.2014.04.00924813095Open DOISearch in Google Scholar
Latty D, Stuart KE, Wang W, Ahern V. Review of deep inspiration breath-hold technique for the treatment of breast cancer. J Med Radiat Sci 2015; 62: 74-81. 10.1002/jmrs.9626229670LattyDStuartKEWangWAhernV.Review of deep inspiration breath-hold technique for the treatment of breast cancer201562748110.1002/jmrs.96436480926229670Open DOISearch in Google Scholar
Marks LB, Yorke ED, Jackson A Ten Haken RK, Constine LS, Eisbruch A, et al. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys 2010; 76: 10-9. 10.1016/j.ijrobp.2009.07.1754MarksLBYorkeEDJackson A Ten HakenRKConstineLSEisbruchAUse of normal tissue complication probability models in the clinic20107610910.1016/j.ijrobp.2009.07.1754404154220171502Open DOISearch in Google Scholar
Korreman SS, Pederson AN, Aarup LR, Nøttrup TJ, Specht L, Nyström H. Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer. Int J Radiat Oncol Biol Phys 2006; 65: 1375-80. 10.1016/j.ijrobp.2006.03.04616750314KorremanSSPedersonANAarupLRNøttrupTJSpechtLNyströmH.Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer20066513758010.1016/j.ijrobp.2006.03.04616750314Open DOISearch in Google Scholar
Colgan R, James M, Bartlett FR, Kirby AM, Donovan EM. Voluntary breath-holding for breast cancer radiotherapy is consistent and stable. Br J Radiol 2015; 88: 1-8. 10.1259/bjr.20150309ColganRJamesMBartlettFRKirbyAMDonovanEM.Voluntary breath-holding for breast cancer radiotherapy is consistent and stable2015881810.1259/bjr.20150309473097526268141Open DOISearch in Google Scholar
Kapanen M, Laaksomaa M, Pehkonen J, Haltamo M, Luukkanen H, et al. Effects of multiple breath hold reproducibility on treatment localization and dosimetric accuracy in radiotherapy of left-sided breast cancer with voluntary deep inspiration breath hold technique. Med Dosim 2017; 42: 177-84. 10.1016/j.meddos.2017.02.00428526193KapanenMLaaksomaaMPehkonenJHaltamoMLuukkanenHEffects of multiple breath hold reproducibility on treatment localization and dosimetric accuracy in radiotherapy of left-sided breast cancer with voluntary deep inspiration breath hold technique2017421778410.1016/j.meddos.2017.02.00428526193Open DOISearch in Google Scholar
Bartlett FR, Colgan RM, Carr K, Donovan EM, McNAir HA, Locke I, et al. The UK HeartSpare Study: randomised evaluation of voluntary deep-inspiratory breath-hold in women undergoing breast radiotherapy. Radiother Oncol 2013; 108: 242-7. 10.1016/j.radonc.2013.04.02123726115BartlettFRColganRMCarrKDonovanEMMcNAirHALockeIThe UK HeartSpare Study: randomised evaluation of voluntary deep-inspiratory breath-hold in women undergoing breast radiotherapy2013108242710.1016/j.radonc.2013.04.02123726115Open DOISearch in Google Scholar
Radiation Therapy Oncology Group (RTOG). Breast cancer atlas for radiation therapy planning: consensus definitions. [cited 15 Avg 2017]. Available at: http://www.rtog.org/LinkClick.aspx?fileticket=vzJFhPaBipE%3d&tabid=236http://www.rtog.org/LinkClick.aspx?fileticket=vzJFhPaBipE%3d&tabid=236Search in Google Scholar
Duane F, Aznar M, Bartlett F, Cutter DJ, Darby SC, Jagsi R, et al. A cardiac contouring atlas for radiotherapy. Radiother Oncol 2017; 122: 416-22. 10.1016/j.radonc.2017.01.00828233564DuaneFAznarMBartlettFCutterDJDarbySCJagsiRA cardiac contouring atlas for radiotherapy20171224162210.1016/j.radonc.2017.01.008535650628233564Open DOISearch in Google Scholar
Pierce LJ, Feng M, Griffith KA, Jaqsi R, Boike T, Dryden D, et al. Recent time trends and predictors of heart dose from breast radiation therapy in a large quality consortium of radiation oncology practices. Int J Radiat Oncol Biol Phys 2017; 99: 1154-61. 10.1016/j.ijrobp.2017.07.022PierceLJFengMGriffithKAJaqsiRBoikeTDrydenDRecent time trends and predictors of heart dose from breast radiation therapy in a large quality consortium of radiation oncology practices20179911546110.1016/j.ijrobp.2017.07.02228927756Open DOISearch in Google Scholar
Hjelstuen MH, Mjaaland I, Vikstrom J, Dybvik Kl. Radiation during deep inspiration allows loco-regional treatment of left breast and axillary, supraclavicular, and internal mammary lymph nodes without compromising target coverage or dose restrictions to organs at risk. Acta Oncol 2012; 51: 333-44. 10.3109/0284186X.2011.61851022171587HjelstuenMHMjaalandIVikstromJDybvikKl.Radiation during deep inspiration allows loco-regional treatment of left breast and axillary, supraclavicular, and internal mammary lymph nodes without compromising target coverage or dose restrictions to organs at risk2012513334410.3109/0284186X.2011.61851022171587Open DOISearch in Google Scholar
Nissen HD, Appelt AL. Improved heart, lung, and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients. Radiother Oncol 2013: 106: 28-32. 10.1016/j.radonc.2012.10.016NissenHDAppeltAL.Improved heart, lung, and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients2013106283210.1016/j.radonc.2012.10.01623199652Open DOISearch in Google Scholar
Wang W, Purdie TG, Rahman M, Marshal A, Liu FF, Fyles A. Rapid automated treatment planning process to select breast cancer patients for active breathing control to achieve cardiac dose reduction. Int J Radiat Oncol Biol Phys 2012; 82: 386-93. 10.1016/j.ijrobp.2010.09.02621093165WangWPurdieTGRahmanMMarshalALiuFFFylesA.Rapid automated treatment planning process to select breast cancer patients for active breathing control to achieve cardiac dose reduction2012823869310.1016/j.ijrobp.2010.09.02621093165Open DOISearch in Google Scholar
Hayden AJ, Rains M, Tiver K. Deep inspiration breath hold technique reduces heart dose from radiotherapy for left-sided breast cancer. J Med Imaging Radiat Oncol 2012; 56: 462-72. 10.1111/j.1754-9485.2012.02405.xHaydenAJRainsMTiverK.Deep inspiration breath hold technique reduces heart dose from radiotherapy for left-sided breast cancer2012564627210.1111/j.1754-9485.2012.02405.x22883657Open DOISearch in Google Scholar
Reardon KA, Read PW, Morris MM, Reardon MA, Geesy C, Wijesooriya K. A comparative analysis of 3D conformal deep inspiratory-breath hold and free-breathing intensity-modulated radiation therapy for left-sided breast cancer. Med Dosim 2013; 38: 190-5. 10.1016/j.meddos.2013.01.00223453454ReardonKAReadPWMorrisMMReardonMAGeesyCWijesooriyaK.A comparative analysis of 3D conformal deep inspiratory-breath hold and free-breathing intensity-modulated radiation therapy for left-sided breast cancer201338190510.1016/j.meddos.2013.01.00223453454Open DOISearch in Google Scholar
Borst GR, Sonke JJ, den Hollander S, Betgen A, Remeijer P, van Giersbergen A, et al. Clinical results of image-guided deep inspiration breath hold breast irradiation. Int J Radiat Oncol Biol Phys 2010; 78: 1345-51. 10.1016/j.ijrobp.2009.10.00620207496BorstGRSonkeJJden HollanderSBetgenARemeijerPvan GiersbergenAClinical results of image-guided deep inspiration breath hold breast irradiation20107813455110.1016/j.ijrobp.2009.10.00620207496Open DOISearch in Google Scholar
McIntosh A, Soushtari AN, Benedict SH, Read PW, Wijesooriya K. Quantifying the reproducibility of heart position during treatment and corresponding delivered heart dose in voluntary deep inspiration breath hold for left breast cancer patients treated with external beam radiotherapy. Int J Radiat Oncol Biol Phys 2008; 81: 569-76. 10.1016/j.ijrobp.2011.01.044McIntoshASoushtariANBenedictSHReadPWWijesooriyaK.Quantifying the reproducibility of heart position during treatment and corresponding delivered heart dose in voluntary deep inspiration breath hold for left breast cancer patients treated with external beam radiotherapy2008815697610.1016/j.ijrobp.2011.01.04421531087Open DOISearch in Google Scholar
Segedin B, Petric P. Uncertainties in target volume delineation in radiotherapy - are they relevant and what can we do about them? Radiol Oncol 2016; 50: 254-62. 10.1515/raon-2016-0023.27679540SegedinBPetricP.Uncertainties in target volume delineation in radiotherapy - are they relevant and what can we do about them?2016502546210.1515/raon-2016-0023502465527679540Open DOISearch in Google Scholar
Gierga DP, Turcotte JC, Sharp GC, Sedlacek DE, Cotter CR, Taghian AG. A voluntary breath-hold treatment technique for the left breast with unfavorable cardiac anatomy using surface imaging. Int J Radiation Oncol Biol Phys 2012; 84: 663-8. 10.1016/j.ijrobp.2012.07.2379GiergaDPTurcotteJCSharpGCSedlacekDECotterCRTaghianAG.A voluntary breath-hold treatment technique for the left breast with unfavorable cardiac anatomy using surface imaging201284663810.1016/j.ijrobp.2012.07.237922975605Open DOISearch in Google Scholar