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Breast dynamic contrast enhanced MRI: fibrocystic changes presenting as a non-mass enhancement mimicking malignancy

Zorica C. Milosevic
Zorica C. Milosevic
, 
Mirjan M. Nadrljanski
Mirjan M. Nadrljanski
, 
Zorka M. Milovanovic
Zorka M. Milovanovic
, 
Nina Z. Gusic
Nina Z. Gusic
, 
Slavko S. Vucicevic
Slavko S. Vucicevic
 and 
Olga S. Radulovic
Olga S. Radulovic
   | May 07, 2017
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Article Category: Research Articles
Published Online: May 07, 2017
Page range: 130 - 136
Received: Oct 18, 2016
Accepted: Feb 20, 2017
DOI: https://doi.org/10.1515/raon-2017-0016
Keywords
© 2017 Zorica C. Milosevic, Mirjan M. Nadrljanski, Zorka M. Milovanovic, Nina Z. Gusic, Slavko S. Vucicevic, Olga S. Radulovic
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

DCE-MRI findings of proliferative fibrocystic changes. Axial T1-weighted images, precontrast image (A) and contrast-enhanced image 1 min 23 s after administration of gadolinium (B) with corresponding subtraction image (C), show the segmental, non-mass enhancement (long arrows), measured 2.5×1×2.5 cm, with clumped internal pattern of enhancement. Time-intensity curve is plateau (type 2) with fast wash-in (D) Turbo inversion recovery magnitude (TIRM) sequence (E) show clustered microcysts (short arrows).
DCE-MRI findings of proliferative fibrocystic changes. Axial T1-weighted images, precontrast image (A) and contrast-enhanced image 1 min 23 s after administration of gadolinium (B) with corresponding subtraction image (C), show the segmental, non-mass enhancement (long arrows), measured 2.5×1×2.5 cm, with clumped internal pattern of enhancement. Time-intensity curve is plateau (type 2) with fast wash-in (D) Turbo inversion recovery magnitude (TIRM) sequence (E) show clustered microcysts (short arrows).

Nonproliferative lesion, proliferative lesions without atypia and proliferative lesions with atypia: dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) morphological and enhancement kinetics features, based on BI-RADS lexicon

Statistical differenceProliferative lesions without atypia (N = 6)Proliferative lesions with atypia (N = 29)Non proliferative lesions (N = 11)The DCE-MRI features of fibrocystic change
p = 0.4541110.5 < d < 1 cmSize
52810d ≥ 1cm
p = 0.168371SegmentalNME distribution
32210Regional or diffuse
p = 0.722020HomogeneousNME internalenhancement
143Stippled
5238Heterogeneous orclumped
p = 0.097386PersistentTIC
3193Plateau
022Wash out
p = 0.752285SlowWash-in
1103Moderate
3113Fast
p = 0.0141182PresentMicrocysts (T2Wimages)
5119Absent

Standard dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) protocol for axial-plane images for T1-weighted FLASH 3D precontrast and five postcontrast series

T2-T2-T1-T1-
weightedweightedweightedweighted
MRI sequence/ parametersTIRMTSETSEFLASH 3D
Echo time (ms)6070124.8
Repetition time (ms)769059009109.1
Inversion time (ms)180
Flip angle (°)1501809025
Field of view (mm×mm)340×340340×340340×340340×340
Image matrix320×256384×319320×234576×564
eISSN:
1581-3207
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Radiology, Internal Medicine, Haematology, Oncology
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