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MRI reduces variation of contouring for boost clinical target volume in breast cancer patients without surgical clips in the tumour bed

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Radiology and Oncology

Volume 51 (2017): Issue 2 (June 2017)

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Article Category: Research Articles

Published Online: Mar 17, 2017

Page range: 160 - 168

Received: Dec 05, 2016

Accepted: Feb 19, 2017

DOI: https://doi.org/10.1515/raon-2017-0014

© 2017 Noora Al-Hammadi, Palmira Caparrotti, Saju Divakar, Mohamed Riyas, Suparna Halsnad Chandramouli, Rabih Hammoud, Jillian Hayes, Maeve Mc Garry, Satheesh Prasad Paloor, Primoz Petric

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

(A) Generalized conformity index (CIgen) and (B) accuracy index (AI) as a function of the cavity visualization score (CVS) for CT and MRI based contouring of lumpectomy cavity clinical target volume. None of the patients had surgical clips inserted in the tumor bed. Case numbers are indicated for each modality.

CT and MRI based contouring in two examples with high and low cavity visualization scores (CVS). Observers’ delineations are white and expert consensus (EC) contours black. (A) Case with a CVS of 4.8 on CT and 5 on MRI: mean generalized conformity index (CIgen), accuracy index (AI) and inter-delineation distance (IDD) were 0.79, 0.85 and 2.4 mm on CT and 0.80, 0.86 and 2.2 mm on MRI. (B) Case with a CVS of 2 on CT and 3 on MRI: mean CIgen, AI and IDD were 0.46, 0.61 and 6 mm for CT and 0.63, 0.73 and 4.5 mm for MRI.

Accuracy index (AI) and inter-delineation distances (IDD), based on the expert consensus (EC) delineation as the reference. The differences in AI and IDD between CT and MRI were statistically significant (p < 0.05)

			CT						MRI

Case
		IDD [mm]			AI			IDD [mm]			AI

	Mean	SD	CoV [%]	Mean	SD	CoV [%]	Mean	(SD)	CoV [%]	Mean	SD	CoV [%]
1	2.1	0.8	38	0.88	0.02	3	1.8	0.58	32	0.88	0.01	2
2	3.6	1.9	53	0.78	0.1	12	3.2	1.9	59	0.83	0.02	3
3	3.9	2.6	67	0.67	0.07	10	3.2	1.8	56	0.78	0.02	2
4	2.3	1	43	0.75	0.06	8	2.3	0.9	39	0.77	0.05	6
5	6	4	67	0.61	0.15	24	4.5	2.1	47	0.73	0.14	20
6	2.6	1.1	42	0.82	0.02	2	2.6	1	38	0.83	0.02	2
7	6	4.1	68	0.64	0.09	14	3.6	1.8	50	0.76	0.05	7
8	2.4	1.2	50	0.85	0.02	2	2.2	1	45	0.86	0.04	4
9	3	2.9	97	0.81	0.04	5	2.9	1.8	62	0.80	0.05	6
10	4.5	3.5	78	0.77	0.07	9	3.3	2	61	0.84	0.02	2
11	3.3	2	61	0.74	0.09	12	2.5	1.3	52	0.83	0.02	3
12	3.4	2.3	68	0.77	0.06	8	3.6	1.7	47	0.80	0.02	2
MEAN	3.6	2.3	61	0.76	0.07	9	3	1.5	49	0.81	0.04	5

Results for inter-observer variation in contouring. The difference in mean generalized conformity index (CIgen) between the CT and MRI based contouring was statistically significant (p = 0.007)

Case		CT			MRI

	Mean V [cm3] (SD)	CoV [%]	CIgen	Mean V [cm3] (SD)	CoV [%]	CIgen
1	198 (10)	5	0.85	106 (4)	4	0.87
2	241 (37.5)	16	0.69	256 (28)	11	0.77
3	108 (20.7)	19	0.56	125 (10)	8	0.75
4	75 (18.1)	24	0.64	92 (12)	13	0.69
5	175 (47.9)	27	0.46	217 (68)	31	0.63
6	140 (10.1)	7	0.76	125 (14)	11	0.76
7	103(39.7)	39	0.48	64 (2)	4	0.66
8	180 (22.5)	12	0.79	158 (14)	9	0.8
9	135 (19.8)	15	0.77	126 (20)	16	0.71
10	204 (44.3)	22	0.68	215 (19)	9	0.76
11	99 (14.4)	15	0.66	135 (11)	8	0.79
12	195 (27.3)	14	0.69	210 (29)	14	0.74
MEAN (SD)	154 (26)	18	0.67 (0.12)	152 (19)	12	0.74 (0.07)

eISSN:: 1581-3207
Language:: English

Publication timeframe:: 4 times per year
Journal Subjects:: Medicine, Clinical Medicine, Radiology, Internal Medicine, Haematology, Oncology

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