<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2016-0040_s_101_w2aab3b8c49b1b7b1aab1c16b1Aa"><h3>Background</h3><p>Advanced follicular lymphoma (FL) and mantle cell lymphoma (MCL) are incurable diseases with conventional treatment. The high dose treatment (HDT) with autologous stem cell transplantation (ASCT), however, offers a certain proportion of these patients the prospect of a prolonged disease-free and overall survival. The aim of this study was to investigate the event free survival (EFS) and overall survival (OS) in patients with FL and MCL treated with ASCT.</p></sec><sec id="j_raon-2016-0040_s_102_w2aab3b8c49b1b7b1aab1c16b2Aa"><h3>Patients and methods</h3><p>Seventeen patients with FL and 29 patients with MCL were included, 15 of them were transplanted to consolidate the response to second line treatment and 24 to consolidate their first remission, respectively. All were conditioned with total body irradiation (TBI) and high dose cyclophosphamide between 2006 and 2014 and all were transplanted with peripheral blood stem cells.</p></sec><sec id="j_raon-2016-0040_s_103_w2aab3b8c49b1b7b1aab1c16b3Aa"><h3>Results</h3><p>The estimated 5-year OS for FL was 87.8% (95% confidence interval [CI] 59.5%–96.8%) and for MCL 79.3% (95% CI 56.1%–91.1%), respectively. The estimated 5-year EFS for FL was 76.0% (95% CI 48.0%–90.3%) and for MCL 69.8% (95% CI 45.5%–84.8%), respectively. There were no secondary hematological malignancies observed in either group.</p></sec><sec id="j_raon-2016-0040_s_104_w2aab3b8c49b1b7b1aab1c16b4Aa"><h3>Conclusions</h3><p>Based on above results, the ASCT with TBI is a good treatment option in terms of long-term survival for patients with follicular and mantle cell lymphoma demonstrating a relatively low rate of late toxicities and secondary malignancies.</p></sec></abstract>

BackgroundAdvanced follicular lymphoma (FL) and mantle cell lymphoma (MCL) are incurable diseases with conventional treatment. The high dose treatment (HDT) with autologous stem cell transplantation (ASCT), however, offers a certain proportion of these patients the prospect of a prolonged disease-free and overall survival. The aim of this study was to investigate the event free survival (EFS) and overall survival (OS) in patients with FL and MCL treated with ASCT.Patients and methodsSeventeen patients with FL and 29 patients with MCL were included, 15 of them were transplanted to consolidate the response to second line treatment and 24 to consolidate their first remission, respectively. All were conditioned with total body irradiation (TBI) and high dose cyclophosphamide between 2006 and 2014 and all were transplanted with peripheral blood stem cells.ResultsThe estimated 5-year OS for FL was 87.8% (95% confidence interval [CI] 59.5%–96.8%) and for MCL 79.3% (95% CI 56.1%–91.1%), respectively. The estimated 5-year EFS for FL was 76.0% (95% CI 48.0%–90.3%) and for MCL 69.8% (95% CI 45.5%–84.8%), respectively. There were no secondary hematological malignancies observed in either group.ConclusionsBased on above results, the ASCT with TBI is a good treatment option in terms of long-term survival for patients with follicular and mantle cell lymphoma demonstrating a relatively low rate of late toxicities and secondary malignancies.

Long-term outcomes of high dose treatment and autologous stem cell transplantation in follicular and mantle cell lymphomas – a single centre experience

Department of Biostatistics and Medical Informatics

Radiology and Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

BackgroundAdvanced follicular lymphoma (FL) and mantle cell lymphoma (MCL) are incurable diseases with conventional treatment. The high dose treatment (HDT)...

	Follicular lymphoma group N = 17	Mantle cell lymphoma group N = 29
Sex (F/M)	7 (41.2%) / 10 (58.8%)	6 (20.7%) / 23 (79. 3%)
Age at diagnosis in years, median FL grade I/II IIIa Pleomorphic/blastoid MCL	46 (range 29–62) 13 (76.5%) 4 (23.5%) /	54 (range 38–65) / 10 (34.5%)
Distribution according to FLIPI or MIPI low risk/intermediate/high risk HDT/ASCT After first line treatment* After second line treatment or later according to national guidelines; CR = complete remission; F = female; FL = follicular lymphoma; FLIPI = follicular lymphoma international prognostic index; HDT/ASCT = high dose treatment/autologous stem cell transplantation; M = male; MCL = mantle cell lymphoma; MIPI = international prognostic index for mantle cell lymphoma; N = number; PR = partial remission	4 (23.5%) / 9 (52.9%) / 4 (23.5%) 3 (17.6%) 14 (82.4%)	24 (82.8%) / 4 (13.8%) / 1 (3.4%) 24 (82.7%) 5 (17.2%)
Disease status prior HDT/ASCT CR PR Documented rituximab treatment before HDT/ ASCT	5 (29.4%) 12 (70.6%) 17 (100%)	13 (44.8%) 16 (55.2%) 29 (100%)

Long-term outcomes of high dose treatment and autologous stem cell transplantation in follicular and mantle cell lymphomas – a single centre experience

Article Category: Research Article

Published Online: Jun 24, 2016

Page range: 81 - 87

Received: Jan 06, 2016

Accepted: May 24, 2016

DOI: https://doi.org/10.1515/raon-2016-0040

© 2017 Lucka Boltezar, Karlo Pintaric, Jože Pretnar, Maja Pohar Perme, Barbara Jezersek Novakovic

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Patients’ characteristics