About this article
Article Category: Research Article
Published Online: Jun 24, 2016
Page range: 1 - 7
Received: Mar 18, 2015
Accepted: May 20, 2016
DOI: https://doi.org/10.1515/raon-2016-0038
© 2017 Ziga Snoj, Igor Kocijancic, Erik Skof
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Possible prognostic factors
| Characteristic | n | MST (months) | 1-year survival (%) | 2-year survival (%) | p-value | ||
|---|---|---|---|---|---|---|---|
| Gender | Female | 31 | - | 77.3 | 77.3 | ||
| Male | 16 | 4 | 31.3 | 20.8 | 0.004 | ||
| Age | < 40 | 29 | - | 75.9 | 58.4 | ||
| ≥ | 40 | 18 4 | 33.3 | 33.3 | 0.009 | ||
| Size (cm) | < 5 | 20 | - | 80.0 | 80.0 | ||
| ≥ 5 | 16 3 | 25.0 | 0.0 | 0.000 | |||
| Metastasis | Yes | 21 | 4 | 42.9 | 0.95 | ||
| No | 26 | - | 84.6 | 84.6 | 0.000 | ||
| Smoking | Yes | 11 4 | 0.0 | 0.0 | |||
| No | 36 | - | 69.4 | 69.4 | 0.001 | ||
| Female – gestational history | Positive | 14 | - | 69.6 | 69.6 | ||
| Negative | 16 | - | 56.3 | 56.3 | 0.040 | ||
| S | Yes | 9 | - | 55.6 | 55.6 | ||
| No | 32 | - | 71.0 | 64.5 | 0.458 | ||
| C | Yes | 7 | 3 | 28.6 | 28.6 | ||
| No | 34 | - | 75.8 | 69.9 | 0.016 | ||
| S+C | Yes | 24 | - | 83.3 | 56.3 | ||
| No | 17 | 4 | 41.2 | 41.2 | 0.010 | ||
Primary pulmonary choriocarcinoma: Summary of reported cases
| No of patients | 55 |
|---|---|
| Gender, male/female | 17/38 |
| Median age all patients, years | 34 |
| Median age female, years | 33 |
| Median age male, years | 60 |
| Initial symptom | |
| Cough | 22 |
| Dyspnea | 17 |
| Hemoptysis | 14 |
| Chest pain | 11 |
| Asymptomatic | 8 |
| Location | |
| Right / Left lung | 29/18 |
| Right upper lobe | 11 |
| Right middle lobe | 3 |
| Right lower lobe | 15 |
| Left upper lobe | 12 |
| Left lower lobe | 4 |
| Bilateral | 2 |
| Tumor size, cm | |
| ≤5 | 23 |
| > 5, ≤ 10 | 13 |
| > 10 | 8 |
| Treatment | |
| S | 10 |
| C | 8 |
| RT | 3 |
| S + C | 24 |
| S + C + RT | 3 |
Differences between female and male patients primary pulmonary choriocarcinoma
| Characteristics | Female | Male | p-value | |
|---|---|---|---|---|
| Age | < 40 | 30 | 4 | |
| ≥ 40 | 9 | 13 | 0.000 | |
| Size, cm | < 5 | 17 | 7 | |
| ≥ 5 | 12 | 8 | 0.162 | |
| Metastasis | Yes | 15 | 10 | |
| No | 24 | 7 | 0.161 | |
| Smoking | Yes | 2 | 9 | |
| No | 37 | 8 | 0.000 | |
| Hemoptysis | Yes | 13 | 5 | |
| No | 25 | 11 | 0.780 | |
| Treatment | ||||
| S | Yes | 24 | 9 | |
| No | 4 | 4 | 0.221 | |
| C | Yes | 21 | 10 | |
| No | 7 | 3 | 0.895 | |
| S+C | Yes | 17 | 7 | |
| No | 11 | 6 | 0.682 |
Multivariate analysis of prognostic factors, Cox proportional hazards model
| S+C | HR | 95% CI | p-value |
|---|---|---|---|
| Yes | 0.147 | 0.036 – 0.598 | 0.007 |
| No | 1 | ||
| Smoking | |||
| Yes | 1.827 | 0.418–7.982 | 0.423 |
| No | 1 | ||
| Gender | |||
| Male | 1.266 | 0.248–6.466 | 0.776 |
| Female | 1 | ||
| Tumour size, cm | |||
| ≥ 5 | 6.622 | 1.622–27.031 | 0.008 |
| < 5 | 1 | ||
| Age, years | |||
| ≥ 40 | 0.879 | 0.164–4.703 | 0.880 |
| < 40 | 1 |