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The role of neoadjuvant chemotherapy in patients with advanced (stage IIIC) epithelial ovarian cancer

Erik Škof
Erik Škof
, 
Sebastjan Merlo
Sebastjan Merlo
, 
Gasper Pilko
Gasper Pilko
 and 
Borut Kobal
Borut Kobal
   | Jul 19, 2016
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Article Category: Research Article
Published Online: Jul 19, 2016
Page range: 341 - 346
Received: May 29, 2015
Accepted: Sep 05, 2015
DOI: https://doi.org/10.1515/raon-2016-0034
Keywords
© 2016 Radiol Oncol
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Figure 1

Progression free survival of patients after primary surgery and neoadjuvant chemotherapy (NACT).
Progression free survival of patients after primary surgery and neoadjuvant chemotherapy (NACT).

Figure 2

Overall survival of patients after primary surgery and neoadjuvant chemotherapy (NACT).
Overall survival of patients after primary surgery and neoadjuvant chemotherapy (NACT).

Figure 3

Survival curves of patients after different surgical outcomes.NACT = neoadjuvant chemotherapy; R0 = no macroscopic residual disease; R1= < 1 cm residual disease; R2= >1 cm residual disease
Survival curves of patients after different surgical outcomes.NACT = neoadjuvant chemotherapy; R0 = no macroscopic residual disease; R1= < 1 cm residual disease; R2= >1 cm residual disease

Five-year and eight-year survival of patients after different surgical outcomes

Five-year survivalEight year survivalp
Surgery - R0 resection62.5%62.5%P < 0.0001
NACT -R0 resection20.6%17.1%
Surgery - R1 resection38.9%27.8%P < 0.0001
NACT -R1 resection16.7%11.1%
Surgery - R2 resection15.5%0%P < 0.0001
NACT -R2 resection0%0%
Inoperable disease0%0%-

Factors correlated with survival on multivariate analysis

p
Age (years)
                                        < 600.775
                                        ≥ 60
Histology
                                        High grade serous0.370
                                        Other histology
Performance status
                                        0 or 1
                                        > 10.003
Extent of residual disease
                                        R0
                                        R1< 0.0001
                                        R2
Therapy
                                        Primary surgery
                                        NACT0.038

The characteristics of patients and surgical outcomes

Primary surgery N = 80NACT N = 80p
Age (years)60.264.80.006
High grade serous43 (54%)53 (66%)0.307
Performance 0 or 166 (83%)32 (40%)< 0.0001
                                                    >114 (17%)48 (60%)
R0 resection16 (20%)34 (42%)0.011
R1 resection18 (23%)18 (22%)1.0
R2 resection46 (57%)11 (14%)< 0.0001
Inoperable-17 (21%)-
PFS (months)17.714.10.213
OS (months)31.624.80.012

Factors correlated with survival on univariate analysis

p
Age (years)
                                        < 600.008
                                        ≥ 60
Histology
                                        High grade serous0.066
                                        Other histology
Performance status
                                        0 or 1
                                        > 1< 0.0001
Extent of residual disease
                                        R0
                                        R1< 0.0001
                                        R2
Therapy
                                        surgery Primary
                                        NACT0.012
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