<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm.</p></sec><sec><h3>Patients and methods</h3><p>Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma.</p></sec><sec><h3>Results</h3><p>Carcinoma was diagnosed in follicular and Hürthle cell neoplasm in 143/428 and 64/309 of cases, respectively. A recurrence in regional lymph nodes occurred in 12/207 patients (6%) during a median follow-up of 55 months. Among patients with carcinoma a recurrence in regional lymph nodes was diagnosed in follicular and Hürthle cell neoplasms in 2% and 14%, respectively (p = 0.002). Recurrence in regional lymph nodes was diagnosed in 3/428 of all patients with follicular neoplasm and 9/309 of all patients with Hürthle cell neoplasm.</p></sec><sec><h3>Conclusions</h3><p>Recurrence in lymph nodes was diagnosed in 0.7% of patients with a preoperative diagnosis of follicular neoplasm and 3% of patients with a Hürthle cell neoplasm. A recurrence in regional lymph nodes is rare in patients with carcinoma and preoperative diagnosis of follicular neoplasm. Preoperative neck ultrasound examination in patients with a follicular neoplasm is probably not useful, but in patients with Hurtle cell neoplasm it may be useful.</p></sec></abstract>

BackgroundPreoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm.Patients and methodsAltogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma.ResultsCarcinoma was diagnosed in follicular and Hürthle cell neoplasm in 143/428 and 64/309 of cases, respectively. A recurrence in regional lymph nodes occurred in 12/207 patients (6%) during a median follow-up of 55 months. Among patients with carcinoma a recurrence in regional lymph nodes was diagnosed in follicular and Hürthle cell neoplasms in 2% and 14%, respectively (p = 0.002). Recurrence in regional lymph nodes was diagnosed in 3/428 of all patients with follicular neoplasm and 9/309 of all patients with Hürthle cell neoplasm.ConclusionsRecurrence in lymph nodes was diagnosed in 0.7% of patients with a preoperative diagnosis of follicular neoplasm and 3% of patients with a Hürthle cell neoplasm. A recurrence in regional lymph nodes is rare in patients with carcinoma and preoperative diagnosis of follicular neoplasm. Preoperative neck ultrasound examination in patients with a follicular neoplasm is probably not useful, but in patients with Hurtle cell neoplasm it may be useful.

Recurrence rate in regional lymph nodes in 737 patients with follicular or Hürthle cell neoplasms

Department of Radiology, Institute of Oncology Ljubljana, Ljubljana, Slovenia

Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia

Radiology and Oncology

BackgroundPreoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for...

Carcinoma type	Total	Recurrence in regional lymph nodes		p-value
Carcinoma type	Total	No	Yes	p-value
Follicular	39	37	2	0.008
Hürthle cell	50	42	8
Papillary – classical variant	21	20	1
Papillary – follicular variant	90	89	1
Papillary – other variant	7	7	0
pT1	69	69	0	0.067
pT2	68	62	6
pT3	64	59	5
pT4	6	5	1
pN0	205	194	11	0.113
pN1	2	1	1	0.113
M0	197	188	9	0.014
M1	10	7	3	0.014
Tumor diameter 0.4-4 cm	145	137	8	0.75
Tumor diameter 4.01-11 cm	62	58	4	0.75
Total	207	195	12	–

Type of neoplasm	Recurrence in regional lymph nodes		Total
Type of neoplasm	No	Yes	Total
Follicular	19	0	19
Hüthle cell	7	1	8
Total	26	1	27

Carcinoma type	Type of neoplasm		Total
Carcinoma type	Follicular neoplasm	Hürthle cell neoplasm	Total
Follicular	31	8	39
Hürthle cell	12	38	50
P apillary - classical variant	16	5	21
Papillary - follicular variant	81	9	90
Papillary - other variant Oncocytic variant in 4 cases, trabecular variant in 2 cases, poorly differentiated thyroid carcinoma in 1 case	3	4	7
Total	143	64	207

Recurrence rate in regional lymph nodes in 737 patients with follicular or Hürthle cell neoplasms

Article Category: Research Article

Published Online: Jul 19, 2016

Page range: 269 - 273

Received: Nov 05, 2015

Accepted: Mar 07, 2016

DOI: https://doi.org/10.1515/raon-2016-0025

© 2016 Radiol Oncol

This content is free.

Recurrence rate in regional lymph nodes and subtype of carcinoma, pT, pN, M and tumor size in 207 patients with malignant follicular or Hürthle cell neoplasm

Preoperative neck US and recurrence in regional lymph nodes in patients with follicular and Hürthle cell neoplasms (Fisher’s exact test p = 0.296)

Distribution of follicular and Hürthle cell neoplasms and carcinoma subtype