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Uncertainties in target volume delineation in radiotherapy – are they relevant and what can we do about them?


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Pötter R, Georg P, Dimopoulos JC, Grimm M, Berger D, Nesvacil N, et al. Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer. Radiother Oncol 2011; 100: 116-23.PötterRGeorgPDimopoulosJCGrimmMBergerDNesvacilNClinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancerRadiother Oncol20111001162310.1016/j.radonc.2011.07.012Search in Google Scholar

van Rij C, Oughlane-Heemsbergen W, Ackerstaff A, Lamers E, Balm A, Rasch C. Parotid gland sparing IMRT for head and neck cancer improves xerostomia related quality of life. Radiat Oncol 2008; 3: 41.van RijCOughlane-HeemsbergenWAckerstaffALamersEBalmARaschCParotid gland sparing IMRT for head and neck cancer improves xerostomia related quality of lifeRadiat Oncol200834110.1186/1748-717X-3-41Search in Google Scholar

Van de Steene J, Linthout N, De Mey J, Vinh-Hung V, Claassens C, Noppen M, et al. Definition of gross tumor volume in lung cancer: Inter-observer variability. Radiother Oncol 2002; 62: 37-9.Van de SteeneJLinthoutNDe MeyJVinh-HungVClaassensCNoppenMDefinition of gross tumor volume in lung cancer: Inter-observer variabilityRadiother Oncol20026237910.1016/S0167-8140(01)00453-4Search in Google Scholar

Lee WR, Roach M. III, Michalski J, Moran B, Beyer D. Interobserver variability leads to significant differences in quantifiers of prostate implant adequacy. Int J Radiat Oncol Biol Phys 2002; 54: 457-61.LeeWRRoachMIIIMichalskiJMoranBBeyerDInterobserver variability leads to significant differences in quantifiers of prostate implant adequacyInt J Radiat Oncol Biol Phys2002544576110.1016/S0360-3016(02)02950-4Search in Google Scholar

Kim RY, McGinnis SL, Spencer SA, Meredith RF, Jennelle RLS, Salter MM. Conventional four-field pelvic radiotherapy technique without computed tomography-treatment planning in cancer of the cervix: potential geographic miss and its impact on pelvic control. Int J Radiat Oncol Biol Phys 1995; 31: 109-12.KimRYMcGinnisSLSpencerSAMeredithRFJennelleRLSSalterMMConventional four-field pelvic radiotherapy technique without computed tomography-treatment planning in cancer of the cervix: potential geographic miss and its impact on pelvic controlInt J Radiat Oncol Biol Phys1995311091210.1016/0360-3016(94)00337-KSearch in Google Scholar

Jansen EPM, Nijkamp J, Gubanski M, Lind PARM, Verheij M. Interobserver variation of clinical target volume delineation in gastric cancer. Int J Radiat Oncol 2010; 77: 1166-70.JansenEPMNijkampJGubanskiMLindPARMVerheijMInterobserver variation of clinical target volume delineation in gastric cancerInt J Radiat Oncol20107711667010.1016/j.ijrobp.2009.06.023Search in Google Scholar

Njeh CF, Dong L, Orton CG. IGRT has limited clinical value due to lack of accurate tumor delineation. Med Phys 2008; 33: 136-40.NjehCFDongLOrtonCGIGRT has limited clinical value due to lack of accurate tumor delineationMed Phys2008331364010.1118/1.4789492Search in Google Scholar

Weiss E, Hess CF. The impact of gross tumor volume (GTV) and clinical target volume (CTV) definition on the total accuracy in radiotherapy. Strahlenther Onkol 2003; 179: 21-30.WeissEHessCFThe impact of gross tumor volume (GTV) and clinical target volume (CTV) definition on the total accuracy in radiotherapyStrahlenther Onkol2003179213010.1007/s00066-003-0976-5Search in Google Scholar

Thiagarajan A, Caria N, Schöder H, Iyer NG, Wolden S, Wong RJ, et al. Target volume delineation in oropharyngeal cancer: impact of PET, MRI, and physical examination. Int J Radiat Oncol 2012; 83: 220-7.ThiagarajanACariaNSchöderHIyerNGWoldenSWongRJTarget volume delineation in oropharyngeal cancer: impact of PET, MRI, and physical examinationInt J Radiat Oncol201283220710.1016/j.ijrobp.2011.05.060Search in Google Scholar

Weiss E, Richter S, Krauss T, Metzelthin SI, Hille A, Pradier O, et al. Conformal radiotherapy planning of cervix carcinoma: differences in the delineation of the clinical target volume. A comparison between gynaecologic and radiation oncologists. Radiother Oncol 2003; 67: 87-95.WeissERichterSKraussTMetzelthinSIHilleAPradierOConformal radiotherapy planning of cervix carcinoma: differences in the delineation of the clinical target volume. A comparison between gynaecologic and radiation oncologistsRadiother Oncol200367879510.1016/S0167-8140(02)00373-0Search in Google Scholar

Boersma LJ, Janssen T, Elkhuizen PHM, Poortmans P, van der Sangen M, Scholten AN, et al. Reducing interobserver variation of boost-CTV delineation in breast conserving radiation therapy using a pre-operative CT and delineation guidelines. Radiother Oncol 2012; 103: 178-82.BoersmaLJJanssenTElkhuizenPHMPoortmansPvan der SangenMScholtenANReducing interobserver variation of boost-CTV delineation in breast conserving radiation therapy using a pre-operative CT and delineation guidelinesRadiother Oncol20121031788210.1016/j.radonc.2011.12.021Search in Google Scholar

van Mourik AM, Elkhuizen PHM, Minkema D, Duppen JC, van Vliet-Vroegindeweij C. Multiinstitutional study on target volume delineation variation in breast radiotherapy in the presence of guidelines. Radiother Oncol 2010; 94: 286-91.van MourikAMElkhuizenPHMMinkemaDDuppenJCvan Vliet-VroegindeweijCMultiinstitutional study on target volume delineation variation in breast radiotherapy in the presence of guidelinesRadiother Oncol2010942869110.1016/j.radonc.2010.01.009Search in Google Scholar

Struikmans H, Wárlám-Rodenhuis C, Stam T, Stapper G, Tersteeg RJ, Bol GH, et al. Interobserver variability of clinical target volume delineation of glandular breast tissue and of boost volume in tangential breast irradiation. Radiother Oncol 2005; 76: 293-9.StruikmansHWárlám-RodenhuisCStamTStapperGTersteegRJBolGHInterobserver variability of clinical target volume delineation of glandular breast tissue and of boost volume in tangential breast irradiationRadiother Oncol200576293910.1016/j.radonc.2005.03.029Search in Google Scholar

Altorjai G, Fotina I, Lütgendorf-Caucig C, Stock M, Pötter R, Georg D, et al. Cone-beam CT-based delineation of stereotactic lung targets: the influence of image modality and target size on interobserver variability. Int J Radiat Oncol 2012; 82: e265-e72.AltorjaiGFotinaILütgendorf-CaucigCStockMPötterRGeorgDCone-beam CT-based delineation of stereotactic lung targets: the influence of image modality and target size on interobserver variabilityInt J Radiat Oncol201282e265e7210.1016/j.ijrobp.2011.03.042Search in Google Scholar

Giraud P, Elles S, Helfre S, De Rycke Y, Servois V, Carette MF, et al. Conformal radiotherapy for lung cancer: Different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists. Radiother Oncol 2002; 62: 27-36.GiraudPEllesSHelfreSDe RyckeYServoisVCaretteMFConformal radiotherapy for lung cancer: Different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologistsRadiother Oncol200262273610.1016/S0167-8140(01)00444-3Search in Google Scholar

Cattaneo GM, Reni M, Rizzo G, Castellone P, Ceresoli GL, Cozzarini C, et al. Target delineation in post-operative radiotherapy of brain gliomas: inter-observer variability and impact of image registration of MR(pre-operative) images on treatment planning CT scans. Radiother Oncol 2005; 75: 217-23.CattaneoGMReniMRizzoGCastellonePCeresoliGLCozzariniCTarget delineation in post-operative radiotherapy of brain gliomas: inter-observer variability and impact of image registration of MR(pre-operative) images on treatment planning CT scansRadiother Oncol2005752172310.1016/j.radonc.2005.03.012Search in Google Scholar

Rasch C, Steenbakkers R, van Herk M. Target definition in prostate, head, and neck. Semin Radiat Oncol 2005; 15: 136-45.RaschCSteenbakkersRvan HerkMTarget definition in prostate, head, and neckSemin Radiat Oncol2005151364510.1016/j.semradonc.2005.01.005Search in Google Scholar

Tai P, Van Dyk J, Yu E, Battista J, Stitt L, Coad T. Variability of target volume delineation in cervical esophageal cancer. Int J Radiat Oncol Biol Phys 1998; 42: 277-88.TaiPVan DykJYuEBattistaJStittLCoadTVariability of target volume delineation in cervical esophageal cancerInt J Radiat Oncol Biol Phys1998422778810.1016/S0360-3016(98)00216-8Search in Google Scholar

Krengli M, Canillo B, Turri L, Bagnasacco P, Berretta L, Ferrara T, et al. Target volume delineation for preoperative radiotherapy of rectal cancer: inter-observer variability and potential impact of FDG-PET/CT imaging. Technol Cancer Res Treat 2010; 9: 393-8.KrengliMCanilloBTurriLBagnasaccoPBerrettaLFerraraTTarget volume delineation for preoperative radiotherapy of rectal cancer: inter-observer variability and potential impact of FDG-PET/CT imagingTechnol Cancer Res Treat20109393810.1177/15330346100090040820626204Search in Google Scholar

Hamilton CS, Joseph DJ, Skov A, Denham JW. CT scanning for definitive radiotherapy planning of prostate cancer: necessity or nicety? Results from survey of radiation oncologists working at different institutions in Australasia. Australas Radiol 1990; 34: 288-92.HamiltonCSJosephDJSkovADenhamJWCT scanning for definitive radiotherapy planning of prostate cancer: necessity or nicety? Results from survey of radiation oncologists working at different institutions in AustralasiaAustralas Radiol1990342889210.1111/j.1440-1673.1990.tb02658.x2092654Search in Google Scholar

Valicenti RK, Sweet JW, Hauck WW, Hudes RS, Lee T, Dicker AP, et al. Variation of clinical target volume definition in three-dimensional conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 1999; 44: 931-5.ValicentiRKSweetJWHauckWWHudesRSLeeTDickerAPVariation of clinical target volume definition in three-dimensional conformal radiation therapy for prostate cancerInt J Radiat Oncol Biol Phys199944931510.1016/S0360-3016(99)00090-5Search in Google Scholar

Tanderup K, Nesvacil N, Pötter R, Kirisits C. Uncertainties in image guided adaptive cervix cancer brachytherapy: Impact on planning and prescription. Radiother Oncol 2013; 107: 1-5.TanderupKNesvacilNPötterRKirisitsCUncertainties in image guided adaptive cervix cancer brachytherapy: Impact on planning and prescriptionRadiother Oncol20131071510.1016/j.radonc.2013.02.014Search in Google Scholar

Fotina I, Lütgendorf-Caucig C, Stock M, Pötter R, Georg D. Critical discussion of evaluation parameters for inter-observer variability in target definition for radiation therapy. Strahlenther Onkol 2012; 188: 160-7.FotinaILütgendorf-CaucigCStockMPötterRGeorgDCritical discussion of evaluation parameters for inter-observer variability in target definition for radiation therapyStrahlenther Onkol2012188160710.1007/s00066-011-0027-6Search in Google Scholar

Rasch CRN, Steenbakkers RJHM, Fitton I, Duppen JC, Nowak PJ, Pameijer FA, et al. Decreased 3D observer variation with matched CT-MRI, for target delineation in Nasopharynx cancer. Radiat Oncol 2010; 5: 21.RaschCRNSteenbakkersRJHMFittonIDuppenJCNowakPJPameijerFADecreased 3D observer variation with matched CT-MRI, for target delineation in Nasopharynx cancerRadiat Oncol201052110.1186/1748-717X-5-21Search in Google Scholar

Petrič P, Hudej R, Rogelj P, Blas M, Tanderup K, Fidarova E, et al. Uncertainties of target volume delineation in MRI guided adaptive brachytherapy of cervix cancer: a multi-institutional study. Radiother Oncol 2013; 107: 6-12.PetričPHudejRRogeljPBlasMTanderupKFidarovaEUncertainties of target volume delineation in MRI guided adaptive brachytherapy of cervix cancer: a multi-institutional studyRadiother Oncol201310761210.1016/j.radonc.2013.01.014Search in Google Scholar

Seddon B, Bidmead M, Wilson J, Khoo V, Dearnaley D. Target volume definition in conformal radiotherapy for prostate cancer: quality assurance in the MRC RT-01 trial. Radiother Oncol 2000; 56: 73-83.SeddonBBidmeadMWilsonJKhooVDearnaleyDTarget volume definition in conformal radiotherapy for prostate cancer: quality assurance in the MRC RT-01 trialRadiother Oncol200056738310.1016/S0167-8140(00)00191-2Search in Google Scholar

Steenbakkers RJHM, Duppen JC, Fitton I, Deurloo KE, Zijp LJ, Comans EF, et al. Reduction of observer variation using matched CT-PET for lung cancer delineation: A three-dimensional analysis. Int J Radiat Oncol Biol Phys 2006; 64: 435-48.SteenbakkersRJHMDuppenJCFittonIDeurlooKEZijpLJComansEFReduction of observer variation using matched CT-PET for lung cancer delineation: A three-dimensional analysisInt J Radiat Oncol Biol Phys2006644354810.1016/j.ijrobp.2005.06.03416198064Search in Google Scholar

Genovesi D, Cèfaro GA, Vinciguerra A, Augurio A, Di Tommaso M, Marchese R, et al. Interobserver variability of clinical target volume delineation in supra-diaphragmatic {Hodgkin}’s disease: a multi-institutional experience. Strahlenther Onkol 2011; 187: 357-66.GenovesiDCèfaroGAVinciguerraAAugurioADi TommasoMMarcheseRInterobserver variability of clinical target volume delineation in supra-diaphragmatic {Hodgkin}’s disease: a multi-institutional experienceStrahlenther Onkol20111873576610.1007/s00066-011-2221-y21603989Search in Google Scholar

Genovesi D, Ausili Cèfaro G, Trignani M, Vinciguerra A, Augurio A, Di Tommaso M, et al. Interobserver variability of clinical target volume delineation in soft-tissue sarcomas. Cancer Radiother 2014; 18: 89-96.GenovesiDAusili CèfaroGTrignaniMVinciguerraAAugurioADi TommasoMInterobserver variability of clinical target volume delineation in soft-tissue sarcomasCancer Radiother201418899610.1016/j.canrad.2013.11.01124440683Search in Google Scholar

Hong TS, Tome WA, Harari PM. Heterogeneity in head and neck IMRT target design and clinical practice. Radiother Oncol 2012; 103: 92-8.HongTSTomeWAHarariPMHeterogeneity in head and neck IMRT target design and clinical practiceRadiother Oncol201210392810.1016/j.radonc.2012.02.010369472822405806Search in Google Scholar

Buijsen J, van den Bogaard J, van der Weide H, Engelsman S, van Stiphout R, Janssen M, et al. FDG–PET–CT reduces the interobserver variability in rectal tumor delineation. Radiother Oncol 2012; 102: 371-6.BuijsenJvan den BogaardJvan der WeideHEngelsmanSvan StiphoutRJanssenMFDG–PET–CT reduces the interobserver variability in rectal tumor delineationRadiother Oncol2012102371610.1016/j.radonc.2011.12.016Search in Google Scholar

Nijkamp J, de Haas-Kock DFM, Beukema JC, Neelis KJ, Woutersen D, Ceha H, et al. Target volume delineation variation in radiotherapy for early stage rectal cancer in the Netherlands. Radiother Oncol 2012; 102: 14-21.NijkampJde Haas-KockDFMBeukemaJCNeelisKJWoutersenDCehaHTarget volume delineation variation in radiotherapy for early stage rectal cancer in the NetherlandsRadiother Oncol2012102142110.1016/j.radonc.2011.08.011Search in Google Scholar

Patel DA, Chang ST, Goodman KA, Quon A, Thorndyke B, Gambhir SS, et al. Impact of integrated PET/CT on variability of target volume delineation in rectal cancer. Technol Cancer Res Treat 2007; 6: 31-6.PatelDAChangSTGoodmanKAQuonAThorndykeBGambhirSSImpact of integrated PET/CT on variability of target volume delineation in rectal cancerTechnol Cancer Res Treat2007631610.1177/153303460700600105Search in Google Scholar

Gwynne S, Spezi E, Wills L, Nixon L, Hurt C, Joseph G, et al. Toward semi-automated assessment of target volume delineation in radiotherapy trials: The SCOPE 1 Pretrial Test Case. Int J Radiat Oncol 2012; 84: 1037-42.GwynneSSpeziEWillsLNixonLHurtCJosephGToward semi-automated assessment of target volume delineation in radiotherapy trials: The SCOPE 1 Pretrial Test CaseInt J Radiat Oncol20128410374210.1016/j.ijrobp.2012.01.094Search in Google Scholar

Petric P, Hudej R, Rogelj P, Blas M, Segedin B, Logar HB, et al. Comparison of 3D MRI with high sampling efficiency and 2D multiplanar MRI for contouring in cervix cancer brachytherapy. Radiol Oncol 2012; 46: 242-51.PetricPHudejRRogeljPBlasMSegedinBLogarHBComparison of 3D MRI with high sampling efficiency and 2D multiplanar MRI for contouring in cervix cancer brachytherapyRadiol Oncol2012462425110.2478/v10019-012-0023-1Search in Google Scholar

Fox JL, Rengan R, O’Meara W, Yorke E, Erdi Y, Nehmeh S, et al. Does registration of PET and planning CT images decrease interobserver and intraobserver variation in delineating tumor volumes for non-small-cell lung cancer? Int J Radiat Oncol Biol Phys 2005; 62: 70-5.FoxJLRenganRO’MearaWYorkeEErdiYNehmehSDoes registration of PET and planning CT images decrease interobserver and intraobserver variation in delineating tumor volumes for non-small-cell lung cancer?Int J Radiat Oncol Biol Phys20056270510.1016/j.ijrobp.2004.09.020Search in Google Scholar

Leunens G, Weltens A, Vertraete J, van der Schuren E. Quality assessment of medical decision making in radiation oncology: variability in target volume delineation for brain tumours. Radiother Oncol 1993; 29: 169-75.LeunensGWeltensAVertraeteJvan der SchurenEQuality assessment of medical decision making in radiation oncology: variability in target volume delineation for brain tumoursRadiother Oncol1993291697510.1016/0167-8140(93)90243-2Search in Google Scholar

Weltens C, Menten J, Feron M, Bellon E, Demaerel P, Maes F, et al. Interobserver variations in gross tumor volume delineation of brain tumors on computed tomography and impact of magnetic resonance imaging. Radiother Oncol 2001; 60: 49-59.WeltensCMentenJFeronMBellonEDemaerelPMaesFInterobserver variations in gross tumor volume delineation of brain tumors on computed tomography and impact of magnetic resonance imagingRadiother Oncol200160495910.1016/S0167-8140(01)00371-1Search in Google Scholar

Villeirs GM, Van Vaerenbergh K, Vakaet L, Bral S, Claus F, De Neve WJ, et al. Interobserver delineation variation using CT versus combined CT + MRI in intensity-modulated radiotherapy for prostate cancer. Strahlenther Onkol 2005; 181: 424-30.VilleirsGMVan VaerenberghKVakaetLBralSClausFDe NeveWJInterobserver delineation variation using CT versus combined CT + MRI in intensity-modulated radiotherapy for prostate cancerStrahlenther Onkol20051814243010.1007/s00066-005-1383-xSearch in Google Scholar

Segedin B, But Hadzic J, Rogelj P, Sesek M, Zobec Logar HB, Kragelj B, et al. Interobserver variation in MRI and CT based contouring for prostate cancer. [Abstract]. Radiother Oncol 2011; 99(Suppl 1): S285.SegedinBBut HadzicJRogeljPSesekMZobec LogarHBKrageljBInterobserver variation in MRI and CT based contouring for prostate cancer. [Abstract]Radiother Oncol2011991S28510.1016/S0167-8140(11)70837-4Search in Google Scholar

Giezen M, Kouwenhoven E, Scholten AN, Coerkamp EG, Heijenbrok M, Jansen WP, et al. MRI- versus CT-based volume delineation of lumpectomy cavity in supine position in breast-conserving therapy: An exploratory study. Int J Radiat Oncol Biol Phys 2012; 82: 1332-40.GiezenMKouwenhovenEScholtenANCoerkampEGHeijenbrokMJansenWPMRI- versus CT-based volume delineation of lumpectomy cavity in supine position in breast-conserving therapy: An exploratory studyInt J Radiat Oncol Biol Phys20128213324010.1016/j.ijrobp.2011.05.008Search in Google Scholar

Giezen M, Kouwenhoven E, Scholten AN, Coerkamp EG, Heijenbrok M, Jansen WP, et al. Magnetic resonance imaging– versus computed tomography–based target volume delineation of the glandular breast tissue (clinical target volume breast) in breast-conserving therapy: an exploratory study. Int J Radiat Oncol 2011; 81: 804-11.GiezenMKouwenhovenEScholtenANCoerkampEGHeijenbrokMJansenWPMagnetic resonance imaging– versus computed tomography–based target volume delineation of the glandular breast tissue (clinical target volume breast) in breast-conserving therapy: an exploratory studyInt J Radiat Oncol2011818041110.1016/j.ijrobp.2010.07.004Search in Google Scholar

Major T, Gutiérrez C, Guix B, Mózsa E, Hannoun-Levi JM, Lössl K, et al. Interobserver variations of target volume delineation in multicatheter partial breast brachytherapy after open cavity surgery. Brachytherapy 2015; 14: 925-32.MajorTGutiérrezCGuixBMózsaEHannoun-LeviJMLösslKInterobserver variations of target volume delineation in multicatheter partial breast brachytherapy after open cavity surgeryBrachytherapy2015149253210.1016/j.brachy.2015.06.008Search in Google Scholar

Steenbakkers RJH, Deurloo KE, Nowak PJC, Lebesque JV, van Herk M, Rasch CR. Reduction of dose delivered to the rectum and bulb of the penis using MRI delineation for radiotherapy of the prostate. Int J Radiat Oncol 2003; 57: 1269-79.SteenbakkersRJHDeurlooKENowakPJCLebesqueJVvan HerkMRaschCRReduction of dose delivered to the rectum and bulb of the penis using MRI delineation for radiotherapy of the prostateInt J Radiat Oncol20035712697910.1016/S0360-3016(03)01446-9Search in Google Scholar

Emami B, Sethi A, Petruzzelli GJ. Influence of MRI on target volume delineation and IMRT planning in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2003; 57: 481-8.EmamiBSethiAPetruzzelliGJInfluence of MRI on target volume delineation and IMRT planning in nasopharyngeal carcinomaInt J Radiat Oncol Biol Phys200357481810.1016/S0360-3016(03)00570-4Search in Google Scholar

Hellebust TP, Tanderup K, Lervåg C, Fidarova E, Berger D, Malinen E, et al. Dosimetric impact of interobserver variability in MRI-based delineation for cervical cancer brachytherapy. Radiother Oncol 2013; 107: 13-9.HellebustTPTanderupKLervågCFidarovaEBergerDMalinenEDosimetric impact of interobserver variability in MRI-based delineation for cervical cancer brachytherapyRadiother Oncol201310713910.1016/j.radonc.2012.12.01723462706Search in Google Scholar

Gwynne S, Spezi E, Sebag-Montefiore D, Mukherjee S, Miles E, Conibear J, et al. Improving radiotherapy quality assurance in clinical trials: assessment of target volume delineation of the pre-accrual benchmark case. Br J Radiol 2013; 86: 20120398.GwynneSSpeziESebag-MontefioreDMukherjeeSMilesEConibearJImproving radiotherapy quality assurance in clinical trials: assessment of target volume delineation of the pre-accrual benchmark caseBr J Radiol2013862012039810.1259/bjr.20120398363578523392188Search in Google Scholar

Schimek-Jasch T, Troost EG, Rucker G, Prokic V, Avlar M, Duncker-Rohr V, et al. A teaching intervention in a contouring dummy run improved target volume delineation in locally advanced non-small cell lung cancer: Reducing the interobserver variability in multicentre clinical studies. StrahlentherOnkol 2015; 191: 525-33.Schimek-JaschTTroostEGRuckerGProkicVAvlarMDuncker-RohrVA teaching intervention in a contouring dummy run improved target volume delineation in locally advanced non-small cell lung cancer: Reducing the interobserver variability in multicentre clinical studiesStrahlentherOnkol20151915253310.1007/s00066-015-0812-825665799Search in Google Scholar

Khoo ELH, Schick K, Plank AW, Poulsen M, Wong WW, Middleton M, et al. Prostate contouring variation: Can it be fixed? Int J Radiat Oncol Biol Phys 2012; 82: 1923-29.KhooELHSchickKPlankAWPoulsenMWongWWMiddletonMProstate contouring variation: Can it be fixed?Int J Radiat Oncol Biol Phys20128219232910.1016/j.ijrobp.2011.02.05021514071Search in Google Scholar

Steenbakkers RJHM, Duppen JC, Fitton I, Deurloo KE, Zijp L, Uitterhoeve AL, et al. Observer variation in target volume delineation of lung cancer related to radiation oncologist–computer interaction: A “Big Brother” evaluation. Radiother Oncol 2005; 77: 182-90.SteenbakkersRJHMDuppenJCFittonIDeurlooKEZijpLUitterhoeveALObserver variation in target volume delineation of lung cancer related to radiation oncologist–computer interaction: A “Big Brother” evaluationRadiother Oncol2005771829010.1016/j.radonc.2005.09.01716256231Search in Google Scholar

Mamede M, El Fakhri G, Abreu-e-Lima P, Gandler W, Nosé V, Gerbaudo VH. Pre-operative estimation of esophageal tumor metabolic length in FDG-PET images with surgical pathology confirmation. Ann Nucl Med 2007; 21: 553-62.MamedeMEl FakhriGAbreu-e-LimaPGandlerWNoséVGerbaudoVHPre-operative estimation of esophageal tumor metabolic length in FDG-PET images with surgical pathology confirmationAnn Nucl Med2007215536210.1007/s12149-007-0040-0Search in Google Scholar

Zhong X, Yu J, Zhang B, Mu D, Zhang W, Li D, et al. Using 18F-fluorodeoxyglucose positron emission tomography to estimate the length of gross tumor in patients with squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 2009; 73: 136-41.ZhongXYuJZhangBMuDZhangWLiDUsing 18F-fluorodeoxyglucose positron emission tomography to estimate the length of gross tumor in patients with squamous cell carcinoma of the esophagusInt J Radiat Oncol Biol Phys2009731364110.1016/j.ijrobp.2008.04.015Search in Google Scholar

Bradley J, Bae K, Choi N, Forster K, Siegel BA, Brunetti J, et al. A phase II comparative study of gross tumor volume definition with or without PET/ CT fusion in dosimetric planning for non-small-cell lung cancer (NSCLC): primary analysis of Radiation Therapy Oncology Group (RTOG) 0515. Int J Radiat Oncol Biol Phys 2012; 82: 435-41.BradleyJBaeKChoiNForsterKSiegelBABrunettiJA phase II comparative study of gross tumor volume definition with or without PET/ CT fusion in dosimetric planning for non-small-cell lung cancer (NSCLC): primary analysis of Radiation Therapy Oncology Group (RTOG) 0515Int J Radiat Oncol Biol Phys2012824354110.1016/j.ijrobp.2010.09.033Search in Google Scholar

Schaefer A, Kim YJ, Kremp S, Mai S, Fleckenstein J, Bohnenberger H, et al. PET-based delineation of tumour volumes in lung cancer: comparison with pathological findings. Eur J Nucl Med Mol Imaging 2013; 40: 1233-44.SchaeferAKimYJKrempSMaiSFleckensteinJBohnenbergerHPET-based delineation of tumour volumes in lung cancer: comparison with pathological findingsEur J Nucl Med Mol Imaging20134012334410.1007/s00259-013-2407-xSearch in Google Scholar

Daisne J-F, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H, et al. Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology 2004; 233: 93-100.DaisneJ-FDuprezTWeynandBLonneuxMHamoirMReychlerHTumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimenRadiology20042339310010.1148/radiol.2331030660Search in Google Scholar

Breen SL, Publicover J, De Silva S, Pond G, Brock K, O’Sullivan B, et al. Intraobserver and Interobserver Variability in GTV Delineation on FDG-PETCT Images of Head and Neck Cancers. Int J Radiat Oncol 2007; 68: 763-70.BreenSLPublicoverJDe SilvaSPondGBrockKO’SullivanBIntraobserver and Interobserver Variability in GTV Delineation on FDG-PETCT Images of Head and Neck CancersInt J Radiat Oncol2007687637010.1016/j.ijrobp.2006.12.039Search in Google Scholar

Geets X, Daisne J-F, Arcangeli S, Coche E, De Poel M, Duprez T, et al. Inter-observer variability in the delineation of pharyngo-laryngeal tumor, parotid glands and cervical spinal cord: Comparison between CT-scan and MRI. Radiother Oncol 2005; 77: 25-31.GeetsXDaisneJ-FArcangeliSCocheEDe PoelMDuprezTInter-observer variability in the delineation of pharyngo-laryngeal tumor, parotid glands and cervical spinal cord: Comparison between CT-scan and MRIRadiother Oncol200577253110.1016/j.radonc.2005.04.010Search in Google Scholar

Anderson CM, Sun W, Buatti JM, Maley JE, Policeni B, Mott SL, et al. Interobserver and intermodality variability in GTV delineation on simulation CT, FDG-PET, and MR images of head and neck cancer. Jacobs J Radiat Oncol 2014; 1: 006.AndersonCMSunWBuattiJMMaleyJEPoliceniBMottSLInterobserver and intermodality variability in GTV delineation on simulation CT, FDG-PET, and MR images of head and neck cancerJacobs J Radiat Oncol20141006Search in Google Scholar

Rasch CRN, Barillot I, Remeijer P, Touw A, van Herk M, Lebesque J V. Definition of the prostate in CT and MRI: a multi-observer study. Int J Radiat Oncol Biol Phys 1999; 43: 57-66.RaschCRNBarillotIRemeijerPTouwAvan HerkMLebesqueJVDefinition of the prostate in CT and MRI: a multi-observer studyInt J Radiat Oncol Biol Phys199943576610.1016/S0360-3016(98)00351-4Search in Google Scholar

Barkati M, Simard D, Taussky D, Delouya G. Magnetic resonance imaging for prostate bed radiotherapy planning: An inter- and intra-observer variability study. J Med Imaging Radiat Oncol 2015: Nov 16. 10.1111/17549485.12416. [Epub ahead of print].BarkatiMSimardDTausskyDDelouyaGMagnetic resonance imaging for prostate bed radiotherapy planning: An inter- and intra-observer variability studyJ Med Imaging Radiat Oncol2015Nov 1610.1111/17549485.12416Epub ahead of printOpen DOISearch in Google Scholar

Haie-Meder C, Pötter R, Van Limbergen E, Briot E, De Brabandere M, Dimopoulos J, et al. Recommendations from Gynaecological (GYN) GECESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol 2005; 74: 235-45.Haie-MederCPötterRVan LimbergenEBriotEDe BrabandereMDimopoulosJRecommendations from Gynaecological (GYN) GECESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTVRadiother Oncol2005742354510.1016/j.radonc.2004.12.01515763303Search in Google Scholar

Small W Jr, Mell LK, Anderson P, Creutzberg C, De Los Santos J, Gaffney D, et al. Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer. Int J Radiat Oncol Biol Phys 2008; 71: 428-34.SmallWJrMellLKAndersonPCreutzbergCDe Los SantosJGaffneyDConsensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancerInt J Radiat Oncol Biol Phys2008714283410.1016/j.ijrobp.2007.09.042Search in Google Scholar

Harris VA, Staffurth J, Naismith O, Esmail A, Gulliford S, Khoo V et al. Consensus guidelines and contouring atlas for pelvic node delineation in prostate and pelvic node intensity modulated radiation therapy. Int J Radiat Oncol 2015; 92: 874-83.HarrisVAStaffurthJNaismithOEsmailAGullifordSKhooVConsensus guidelines and contouring atlas for pelvic node delineation in prostate and pelvic node intensity modulated radiation therapyInt J Radiat Oncol2015928748310.1016/j.ijrobp.2015.03.021Search in Google Scholar

Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, et al. Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol 2014; 110: 172-81.GrégoireVAngKBudachWGrauCHamoirMLangendijkJADelineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC, CTG, NCRI, RTOG, TROG consensus guidelinesRadiother Oncol20141101728110.1016/j.radonc.2013.10.010Search in Google Scholar

Nielsen MH, Berg M, Pedersen AN, Andersen K, Glavicic V, Jakobsen EH, et al. Delineation of target volumes and organs at risk in adjuvant radiotherapy of early breast cancer: National guidelines and contouring atlas by the Danish Breast Cancer Cooperative Group. Acta Oncol (Madr) 2013; 52: 703-10.NielsenMHBergMPedersenANAndersenKGlavicicVJakobsenEHDelineation of target volumes and organs at risk in adjuvant radiotherapy of early breast cancer: National guidelines and contouring atlas by the Danish Breast Cancer Cooperative GroupActa Oncol (Madr)2013527031010.3109/0284186X.2013.765064Search in Google Scholar

Lim K, Small W, Portelance L, Creutzberg C, Jürgenliemk-Schulz IM, Mundt A, et al. Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer. Int J Radiat Oncol 2011; 79: 348-55.LimKSmallWPortelanceLCreutzbergCJürgenliemk-SchulzIMMundtAConsensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancerInt J Radiat Oncol2011793485510.1016/j.ijrobp.2009.10.075Search in Google Scholar

Wu AJ, Bosch WR, Chang DT, Hong TS, Jabbour SK, Kleinberg LR et al. Expert consensus contouring guidelines for intensity modulated radiation therapy in esophageal and gastroesophageal junction cancer. Int J Radiat Oncol 2015; 92: 911-20.WuAJBoschWRChangDTHongTSJabbourSKKleinbergLRExpert consensus contouring guidelines for intensity modulated radiation therapy in esophageal and gastroesophageal junction cancerInt J Radiat Oncol2015929112010.1016/j.ijrobp.2015.03.030Search in Google Scholar

Fuller CD, Nijkamp J, Duppen J, Rasch CR, Thomas CR Jr, Wang SJ, et al. Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting. Int J Radiat Oncol Biol Phys 2011; 79: 481-9.FullerCDNijkampJDuppenJRaschCRThomasCRJrWangSJProspective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group settingInt J Radiat Oncol Biol Phys201179481910.1016/j.ijrobp.2009.11.012Search in Google Scholar

Wong EK, Truong PT, Kader HA, Nichol AM, Salter L, Petersen R, et al. Consistency in seroma contouring for partial breast radiotherapy: impact of guidelines. Int J Radiat Oncol Biol Phys 2006; 66: 372-6.WongEKTruongPTKaderHANicholAMSalterLPetersenRConsistency in seroma contouring for partial breast radiotherapy: impact of guidelinesInt J Radiat Oncol Biol Phys200666372610.1016/j.ijrobp.2006.05.066Search in Google Scholar

Senan S, van Sornsen de Koste J, Samson M, Tankink H, Jansen P, Nowak PJ, et al. Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer. Radiother Oncol 1999; 53: 247-55.SenanSvan Sornsen de KosteJSamsonMTankinkHJansenPNowakPJEvaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancerRadiother Oncol1999532475510.1016/S0167-8140(99)00143-7Search in Google Scholar

Mitchell DM, Perry L, Smith S, Elliott T, Wylie JP, Cowan RA, et al. Assessing the effect of a contouring protocol on postprostatectomy radiotherapy clinical target volumes and interphysician variation. Int J Radiat Oncol 2009; 75: 990-3.MitchellDMPerryLSmithSElliottTWylieJPCowanRAAssessing the effect of a contouring protocol on postprostatectomy radiotherapy clinical target volumes and interphysician variationInt J Radiat Oncol200975990310.1016/j.ijrobp.2008.12.04219345515Search in Google Scholar

Bowden P, Fisher R, Mac Manus M, Wirth A, Duchesne G, Millward M, et al. Measurement of lung tumor volumes using three-dimensional computer planning software. Int J Radiat Oncol Biol Phys 2002; 53: 566-73.BowdenPFisherRMac ManusMWirthADuchesneGMillwardMMeasurement of lung tumor volumes using three-dimensional computer planning softwareInt J Radiat Oncol Biol Phys2002535667310.1016/S0360-3016(02)02783-9Search in Google Scholar

Jefferies S, Taylor A, Reznek R. Results of a national survey of radiotherapy planning and delivery in the UK in 2007. Clin Oncol 2009; 21: 204-17.JefferiesSTaylorAReznekRResults of a national survey of radiotherapy planning and delivery in the UK in 2007Clin Oncol2009212041710.1016/j.clon.2008.11.017Search in Google Scholar

Hurkmans CW, Borger JH, Pieters BR, Russell NS, Jansen EPM, Mijnheer BJ. Variability in target volume delineation on CT scans of the breast. Int J Radiat Oncol Biol Phys 2001; 50: 1366-72.HurkmansCWBorgerJHPietersBRRussellNSJansenEPMMijnheerBJVariability in target volume delineation on CT scans of the breastInt J Radiat Oncol Biol Phys20015013667210.1016/S0360-3016(01)01635-2Search in Google Scholar

Dewas S, Bibault J-E, Blanchard P, Vautravers-Dewas C, Pointreau Y, Denis F, et al. Delineation in thoracic oncology: a prospective study of the effect of training on contour variability and dosimetric consequences. Radiat Oncol 2011; 6: 118.DewasSBibaultJ-EBlanchardPVautravers-DewasCPointreauYDenisFDelineation in thoracic oncology: a prospective study of the effect of training on contour variability and dosimetric consequencesRadiat Oncol2011611810.1186/1748-717X-6-118319510121929770Search in Google Scholar

Szumacher E, Harnett N, Warner S, Kelly V, Danjoux C, Barker R, et al. Effectiveness of educational intervention on the congruence of prostate and rectal contouring as compared with a gold standard in three-dimensional radiotherapy for prostate. Int J Radiat Oncol Biol Phys 2010; 76: 379-85.SzumacherEHarnettNWarnerSKellyVDanjouxCBarkerREffectiveness of educational intervention on the congruence of prostate and rectal contouring as compared with a gold standard in three-dimensional radiotherapy for prostateInt J Radiat Oncol Biol Phys2010763798510.1016/j.ijrobp.2009.02.00819467804Search in Google Scholar

eISSN:
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology