<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method.<bold>Methods.</bold> The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated.<bold>Results.</bold> Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = −0.837, p &lt; 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p &lt; 0.0001). There was no statistical difference between tissue sampling methods.<bold>Conclusions.</bold> Because ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.</abstract>

Background. The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method.Methods. The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated.Results. Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = −0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods.Conclusions. Because ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.

Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

Department of Radiology, Ataturk University, Medical Faculty, Erzurum, Turkey

Department of Pulmonary Diseases, Ataturk University, Medical Faculty, Erzurum, Turkey

Department of Thoracic Surgery, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey

Department of Radiology, Pamukkale University, Medical Faculty, Denizli, Turkey

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer"}

Background. The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index...

Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

Published Online: Aug 21, 2015

Page range: 250 - 255

Received: Mar 11, 2015

Accepted: Jul 09, 2015

DOI: https://doi.org/10.1515/raon-2015-0032

Keywords
diffusion weighted-magnetic resonance imaging, apparent diffusion coefficient, Ki-67 index, adenocarcinoma, squamous cell carcinoma

© 2015 Adem Karaman et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

Published Online: Aug 21, 2015

Page range: 250 - 255

Received: Mar 11, 2015

Accepted: Jul 09, 2015

DOI: https://doi.org/10.1515/raon-2015-0032

Keywordsdiffusion weighted-magnetic resonance imaging, apparent diffusion coefficient, Ki-67 index, adenocarcinoma, squamous cell carcinoma

© 2015 Adem Karaman et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
diffusion weighted-magnetic resonance imaging, apparent diffusion coefficient, Ki-67 index, adenocarcinoma, squamous cell carcinoma