<abstract xmlns="http://www.w3.org/1999/xhtml"><p><bold>Background.</bold> Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for further improvement in differentiation efficiency remains. This review contains a description of molecular processes underlying the response of stem cells to ionizing radiation, indicating its potential application in differentiation procedures. In the first part, the radiation-induced damage response in various types of stem cells is described. Second, the role of the p53 protein in embryonic and adult stem cells is highlighted. Last, the hypothesis on the mitochondrial involvement in stem cell development including its response to ionizing radiation is presented.</p><p><bold>Conclusions.</bold> In summary, despite the many threats of ionizing radiation concerning genomic instability, subjecting cells to the appropriate dosage of ionizing radiation may become a useful method for enhancing directed differentiation in certain stem cell types.</p></abstract>

Background. Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for further improvement in differentiation efficiency remains. This review contains a description of molecular processes underlying the response of stem cells to ionizing radiation, indicating its potential application in differentiation procedures. In the first part, the radiation-induced damage response in various types of stem cells is described. Second, the role of the p53 protein in embryonic and adult stem cells is highlighted. Last, the hypothesis on the mitochondrial involvement in stem cell development including its response to ionizing radiation is presented.Conclusions. In summary, despite the many threats of ionizing radiation concerning genomic instability, subjecting cells to the appropriate dosage of ionizing radiation may become a useful method for enhancing directed differentiation in certain stem cell types.

The concept of radiation-enhanced stem cell differentiation

Radiobiology Laboratory, Department of Medical Physics, The Greater Poland Cancer Centre

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The concept of radiation-enhanced stem cell differentiation"}

Background. Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed...

The concept of radiation-enhanced stem cell differentiation

Published Online: Aug 21, 2015

Page range: 209 - 216

Received: Mar 09, 2015

Accepted: Jun 05, 2015

DOI: https://doi.org/10.1515/raon-2015-0022

Keywords
stem cells, ionizing radiation, differentiation, regenerative medicine, tissue engineering

© 2015 Adam A. Mieloch et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The concept of radiation-enhanced stem cell differentiation

Published Online: Aug 21, 2015

Page range: 209 - 216

Received: Mar 09, 2015

Accepted: Jun 05, 2015

DOI: https://doi.org/10.1515/raon-2015-0022

Keywordsstem cells, ionizing radiation, differentiation, regenerative medicine, tissue engineering

© 2015 Adam A. Mieloch et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
stem cells, ionizing radiation, differentiation, regenerative medicine, tissue engineering