<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Breast cancer is a heterogenous disease. It consists of several histological subtypes that can be separated by morphology and immunohistochemistry. The aim of our study was to determine the distribution of breast cancer histological and molecular subtypes, and their relationship with clinical and pathological characteristics. A total of 561 patients who underwent breast carcinoma surgical treatment from January 2003 till December 2012 were enrolled in the study. In total, invasive ductal carcinomas not otherwise specified (IDC-NOS) plus invasive ductal carcinomas no special type (IDC-NST) were observed in 430 patients (76.65% of cases), medullar carcinoma in 14 patients (2.45%), other rare ductal carcinoma subtypes in 13 patients (2.31%), lobular carcinoma in 81 patients (14.4%) and tubulolobular carcinoma in 23 patients (4.19%). Ductal carcinoma, lobular and tubulolobular carcinoma had predominantly luminal A and B subtype, whereas medullar carcinoma had HER2-positive and triple-negative (TN) subtype. Tubular, cribriform, mucinous, papillary, and apocrine carcinomas had predominantly luminal A subtype. Significant differences between breast cancer histological subtypes and clinicopathological characteristics were observed. Our study for the first time reported the distribution and characteristics of breast cancer histological subtypes in Latvian women and relationship to clinical and tumour histopathological characteristics.</p></abstract>

Breast cancer is a heterogenous disease. It consists of several histological subtypes that can be separated by morphology and immunohistochemistry. The aim of our study was to determine the distribution of breast cancer histological and molecular subtypes, and their relationship with clinical and pathological characteristics. A total of 561 patients who underwent breast carcinoma surgical treatment from January 2003 till December 2012 were enrolled in the study. In total, invasive ductal carcinomas not otherwise specified (IDC-NOS) plus invasive ductal carcinomas no special type (IDC-NST) were observed in 430 patients (76.65% of cases), medullar carcinoma in 14 patients (2.45%), other rare ductal carcinoma subtypes in 13 patients (2.31%), lobular carcinoma in 81 patients (14.4%) and tubulolobular carcinoma in 23 patients (4.19%). Ductal carcinoma, lobular and tubulolobular carcinoma had predominantly luminal A and B subtype, whereas medullar carcinoma had HER2-positive and triple-negative (TN) subtype. Tubular, cribriform, mucinous, papillary, and apocrine carcinomas had predominantly luminal A subtype. Significant differences between breast cancer histological subtypes and clinicopathological characteristics were observed. Our study for the first time reported the distribution and characteristics of breast cancer histological subtypes in Latvian women and relationship to clinical and tumour histopathological characteristics.

Distribution And Clinicopathological Features Of Breast Cancer Histological Subtypes In Latvia

Latvian Oncology Centre, Rīga East Clinical University Hospital, Hipokrāta iela 4, Rīga, LV-1079, LATVIA

Centre of Pathology, Rīga East University Hospital, Hipokrāta iela 4, Rīga, LV-1079, LATVIA

Faculty of Medicine, University of Latvia, Šarlotes iela 1a, Rīga, LV-1001, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

PIENA DZIEDZERA AUDZĒJA HISTOLOĢISKO APAKŠTIPU IZPLATĪBA SAISTĪBĀ AR KLĪNISKIEM UN PATOLOĢISKIEM RĀDĪTĀJIEM

Breast cancer is a heterogenous disease. It consists of several histological subtypes that can be separated by morphology and immunohistochemistry. The aim of...

Distribution And Clinicopathological Features Of Breast Cancer Histological Subtypes In Latvia

Published Online: Jul 14, 2015

Page range: 14 - 19

Received: Dec 13, 2013

DOI: https://doi.org/10.1515/prolas-2015-0001

Keywords
breast cancer, histological subtypes, molecular subtypes, clinicopathological characteristics

© Andrejs Srebnijs et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Distribution And Clinicopathological Features Of Breast Cancer Histological Subtypes In Latvia

Published Online: Jul 14, 2015

Page range: 14 - 19

Received: Dec 13, 2013

DOI: https://doi.org/10.1515/prolas-2015-0001

Keywordsbreast cancer, histological subtypes, molecular subtypes, clinicopathological characteristics

© Andrejs Srebnijs et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
breast cancer, histological subtypes, molecular subtypes, clinicopathological characteristics