Ischaemia-Driven Optimal Therapeutic Approach in Asymptomatic Patients with High Cardiovascular Risk: The Value of Clinical, Laboratory and Myocardial Spect Imaging Findings

1. Fuster V, Mearns BM. The CVD paradox: mortality vs prevalence. Nat Rev Cardiol. 2009; 6: 669.10.1038/nrcardio.2009.187Search in Google Scholar

2. Shah PK. Screening asymptomatic subjects for subclinical atherosclerosis: can we, does it matter, and should we? J Am Coll Cardiol. 2010; 56: 98-105.Search in Google Scholar

3. Henrik Sillesen, Erling Falk, Rigshospitalet, et al. Why not screen for subclinical atherosclerosis? The Lancet. 2011; 03: 28; 759-762.Search in Google Scholar

4. Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010; 56: e50-103.Search in Google Scholar

5. Wackers FJ, Young LH, Inzucchi SE, et al. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care. 2004; 27: 1954-1961.10.2337/diacare.27.8.1954Search in Google Scholar

6. Carli MF, Hachamovitch R. Should we screen for occult coronary artery disease among asymptomatic patients with diabetes? J Am Coll Cardiol. 2005; 45: 50-53.Search in Google Scholar

7. Rajagopalan N, Miller TD, Hodge DO, Frye RL, Gibbons RJ. Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging. J Am Coll Cardiol. 2005; 45: 43-49.10.1016/j.jacc.2004.06.078Search in Google Scholar

8. Bax JJ, Bonow RO, Tschöepe D, Insucchi SE, Barrett EJ. Early detection of coronary heart disease in diabetic patients without symptoms of coronary artery disease: implications for expanded use of myocardial perfusion imaging. Br J Diabetes Vasc Dis. 2005; 5: 283-288.10.1177/14746514050050050801Search in Google Scholar

9. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. European Heart Journal. (2012) 33, 1635-1701.Search in Google Scholar

10. Shaw LJ, Iskandrian AE. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol. 2004; 11: 171-185.10.1016/j.nuclcard.2003.12.004Search in Google Scholar

11. Kang X, Berman DS, Lewin H, et al. Comparative ability of myocardial perfusion single-photon emission computed tomography to detect coronary artery disease in patients with and without diabetes mellitus. Am Heart J. 1999; 137: 949- 957.10.1016/S0002-8703(99)70421-7Search in Google Scholar

12. Giri S, Shaw LJ, Murthy DR, Travin MI, Miller DD, Hachamovitch R, Borges-Neto S.Search in Google Scholar

13. De Lorenzo A, Lima RS, Siqueira-Fiho AG, Pantoja MR. Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with diabetes mellitus and no known coronary artery disease. Am J Cardiol. 2002; 90: 827-832.10.1016/S0002-9149(02)02702-9Search in Google Scholar

14. Zellweger MJ, Hachamovitch R, Kang X, et al. Prognostic relevance of symptoms versus objective evidence of coronary artery disease in diabetic patients. Eur Heart J. 2004; 25: 543- 550.10.1016/j.ehj.2004.02.01315120050Search in Google Scholar

15. Miller TD, Rajagopalan N, Hodge DO, Frye RL, Gibbons RJ (2004) Yield of stress single-photon emission computed tomography in asymptomatic patients with diabetes. Am Heart J. 147: 890-896.10.1016/j.ahj.2003.08.01515131547Search in Google Scholar

16. Jamieson M. Bourque, MD, MHS; George A. Beller. Stress Myocardial Perfusion Imaging for Assessing Prognosis: An Update. J Am Coll Cardiol Img. 2011; 4(12): 1305-1319.10.1016/j.jcmg.2011.10.00322172788Search in Google Scholar