Open Access

Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module


Cite

1. Cavuoto, P., & Fenech, M. F. (2012). A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat. Rev., 38, 726–736.10.1016/j.ctrv.2012.01.00422342103Search in Google Scholar

2. Lodi, F., Malizia, C., Castellucci, P., Cicoria, G., Fanti, S., & Boschi, S. (2012). Synthesis of oncological [11C] radiopharmaceuticals for clinical PET. Nucl. Med. Biol., 39, 447–460.10.1016/j.nucmedbio.2011.10.01622172394Search in Google Scholar

3. Jacobs, A. H., Thomas, A., Kracht, L. W., Li, H., Dittmar, C., Garlip, G., Galldiks, N., Klein, J. C., Sobesky, J., Hilker, R., Vollmar, S., Herholz, K., Wienhard, K., & Heiss, W. D. (2005). 18F-fluoro-L-thymidine and 11C-methionine as markers for increased transport and proliferation in brain tumors. J. Nucl. Med., 46, 1948–1958.Search in Google Scholar

4. Pirotte, B., Goldman, S., Massager, N., David, P., Wikler, D., Vandesteene, A., Salmon, I., Brotchi, J., & Levivier, M. (2004). Comparison of 18FFDG and 11C methionine for PET-guided stereotactic brain biopsy of gliomas. J. Nucl. Med., 45, 1293–1298.Search in Google Scholar

5. Pötzi, C., Becherer, A., Marosi, C., Karanikas, G., Szabo, M., Dudczak, R., Kletter, K., & Asenbaum, S. (2007). [11C] Methionine and [18F] fluorodeoxyglucose PET in the follow-up of glioblastoma multiforme. J. Neurooncol., 84, 305–314.10.1007/s11060-007-9375-617492401Search in Google Scholar

6. Hasebe, M., Yoshikawa, K., Ohashi, S., Toubaru, S., Kawaguchi, K., Sato, J., Mizoe, J., & Tsujii, H. (2010). A study on the prognostic evaluation of carbon ion radiotherapy for head and neck adenocarcinoma with C-11 methionine PET. Mol. Imaging Biol., 12, 554–562.10.1007/s11307-010-0318-920369300Search in Google Scholar

7. Matsuo, M., Miwa, K., Tanaka, O., Shinoda, J., Nishibori, H., Tsuge, Y., Yano, H., Iwama, T., Hayashi, S., Hoshi, H., Yamada, J., Kanematsu, M., & Aoyama, H. (2012). Impact of [11C]methionine positron emission tomography for target definition of glioblastoma multiforme in radiation therapy planning. Int. J. Radiat. Oncol. Biol. Phys., 82, 83–89.10.1016/j.ijrobp.2010.09.02021095072Search in Google Scholar

8. Comar, D., Cartron, J., Maziere, M., & Marazano, C. (1976). Labelling and metabolism of methionine-methyl-11C. Eur. J. Nucl. Med., 1, 11–14.10.1007/BF002532601017425Search in Google Scholar

9. European Pharmacopoeia, 8th ed. (2014).Search in Google Scholar

10. Application no. G004503 Supelco: HPLC Analysis of Methionine Enantiomers on Astec® CHIROBIOTIC® T.Search in Google Scholar

11. Pascali, C., Bogni, A., Iwata, R., Decise, D., Crippa, F., & Bombardieri, E. (1999). High efficiency preparation of L-[S-methyl-11C]methionine by on-column [11C] methylation on C18 Sep-Pak. J. Label. Compd. Radiopharm., 42, 715–724. DOI: 10.1002/(SICI)1099-1344(199908)42:8<715.Search in Google Scholar

12. Lodi, F., Rizzello, A., Trespidi, S., Di Pierro, D., Marengo, M., Farsad, M., Fanti, S., Al-Nahhas, A., Rubello, D., & Boschi, S. (2008). Reliability and reproducibility of N-[11C]methyl-choline and L-(S-methyl-[11C])methionine solid-phase synthesis: a useful and suitable method in clinical practice. Nucl. Med. Commun., 29, 736–740.10.1097/MNM.0b013e3282ffb44c18753828Search in Google Scholar

13. Gómez, V., Gispert, J. D., Amador, V., & Llop, J. (2008). New method for routine production of L-[methyl-11C]methionine: in loop synthesis. J. Label. Compd. Radiopharm., 51, 83–86.10.1002/jlcr.1483Search in Google Scholar

14. Cheung, M. K., & Ho, C. L. (2009). A simple, versatile, low-cost and remotely operated apparatus for [11C]acetate, [11C]choline, [11C]methionine and [11C] PIB synthesis. Appl. Radiat. Isot., 67, 581–589.10.1016/j.apradiso.2008.08.01819168366Search in Google Scholar

15. Lodi, F., Trespidi, S., Di Pierro, D., Marengo, M., Farsad, M., Fanti, S., Franchi, R., & Boschi, S. (2007). A simple Tracerlab module modification for automated on-column [11C]methylation and [11C] carboxylation. Appl. Radiat. Isot., 65, 691–695.10.1016/j.apradiso.2006.10.01117158055Search in Google Scholar

16. Pascali, C., Bogni, A., Cucchi, C., Laera, L., Crispu, O., Maiocchi, G., Crippa, F., & Bombardieri, E. (2011) Detection of additional impurities in the UV-chromatogram of L-[S-methyl-11C]methionine. J. Radioanal. Nucl. Chem., 288, 405–409.Search in Google Scholar

17. Schmitz, F., Plenevaux, A., Del-Fiore, G., Lemaire, C., Comar, D., & Luxen, A. (1995). Fast routine production of L-[11C-methyl]methionine with Al2O3KF. Appl. Radiat. Isot., 46(9), 893–897.10.1016/0969-8043(95)00181-CSearch in Google Scholar

18. Kobayashi, M., Hashimoto, F., Ohe, K., Nadamura, T., Nishi, K., Shikano, N., Nishii, R., Higashi, T., Okazawa, H., & Kawai, K. (2012). Transport mechanism of 11C-labeled L- and D-methionine in human-derived tumor cells. Nucl. Med. Biol., 39(8), 1213–1218.10.1016/j.nucmedbio.2012.06.00622795787Search in Google Scholar

19. Fukumura, T., Nakao, R., Yamaguchi, M., & Suzuki, K. (2004). Stability of 11C labeled PET radiopharmaceuticals. Appl. Radiat. Isot., 61, 1279–1287.10.1016/j.apradiso.2004.04.01115388122Search in Google Scholar

20. Bogni, A., Bombardieri, E., Iwata, R., Cadini, C., & Pascali, C. (2003). Stability of L-[S-methyl-11C] methionine solutions. J. Radioanal. Nucl. Chem., 256, 199–203.10.1023/A:1023964712999Search in Google Scholar

eISSN:
0029-5922
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Chemistry, Nuclear Chemistry, Physics, Astronomy and Astrophysics, other