<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Dynamic contrast enhanced MRI (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) are perfusion imaging techniques used mainly for clinical and preclinical measurement of vessel permeability and capillary blood flow, respectively. It is advantageous to apply both methods to exploit their complementary information about the perfusion status of the tissue. We propose a novel acquisition method that combines advantages of the current simultaneous and sequential acquisition. The proposed method consists of a DCE-MRI acquisition interrupted by DSC-MRI acquisition. A new method for processing of the DCE-MRI data is proposed which takes the interleaved acquisition into account. Analysis of both the DCE- and DSC-MRI data is reformulated so that they are approximated by the same pharmacokinetic model (constrained distributed capillary adiabatic tissue homogeneity model). This provides a straightforward evaluation of the methodology as some of the estimated DCE- and DSC-MRI perfusion parameters should be identical. Evaluation on synthetic data showed an acceptable precision and no apparent bias introduced by the interleaved character of the DCE-MRI acquisition. Intravascular perfusion parameters obtained from clinical glioma data showed a fairly high correlation of blood flow estimates from DCE- and DSC-MRI, however, an unknown scaling factor was still present mainly because of the tissue-specific <inline-formula><alternatives><inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_msr-2018-0036_eq_001.png"></inline-graphic><math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mrow><msubsup><mrow><mi>r</mi></mrow><mn>2</mn><mo>*</mo></msubsup></mrow></math><tex-math>$r_2^*$</tex-math></alternatives></inline-formula> relaxivity. The results show validity of the proposed acquisition method. They also indicate that simultaneous processing of both DCE- and DSC-MRI data with joint estimation of some perfusion parameters (included in both DCE- and DSC-MRI) might be possible to increase the reliability of the DCE- and DSC-MRI methods alone.</p></abstract>

Dynamic contrast enhanced MRI (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) are perfusion imaging techniques used mainly for clinical and preclinical measurement of vessel permeability and capillary blood flow, respectively. It is advantageous to apply both methods to exploit their complementary information about the perfusion status of the tissue. We propose a novel acquisition method that combines advantages of the current simultaneous and sequential acquisition. The proposed method consists of a DCE-MRI acquisition interrupted by DSC-MRI acquisition. A new method for processing of the DCE-MRI data is proposed which takes the interleaved acquisition into account. Analysis of both the DCE- and DSC-MRI data is reformulated so that they are approximated by the same pharmacokinetic model (constrained distributed capillary adiabatic tissue homogeneity model). This provides a straightforward evaluation of the methodology as some of the estimated DCE- and DSC-MRI perfusion parameters should be identical. Evaluation on synthetic data showed an acceptable precision and no apparent bias introduced by the interleaved character of the DCE-MRI acquisition. Intravascular perfusion parameters obtained from clinical glioma data showed a fairly high correlation of blood flow estimates from DCE- and DSC-MRI, however, an unknown scaling factor was still present mainly because of the tissue-specific r2*$r_2^*$ relaxivity. The results show validity of the proposed acquisition method. They also indicate that simultaneous processing of both DCE- and DSC-MRI data with joint estimation of some perfusion parameters (included in both DCE- and DSC-MRI) might be possible to increase the reliability of the DCE- and DSC-MRI methods alone.

Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI

Institute of Scientific Instruments of the Czech Academy of Sciences

Department of Biomedical Engineering, The Faculty of Electrical Engineering and Communication

Department of Theoretical and Experimental Electrical Engineering, The Faculty of Electrical Engineering and Communication

Institute of Information Theory and Automation of the Czech Academy of Sciences

Department of Radiology and Nuclear Medicine

The University Hospital Brno and Masaryk University

The Department of Biomedicine, Faculty of Medicine

Measurement Science Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI"}

Dynamic contrast enhanced MRI (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) are perfusion imaging techniques used mainly for clinical and...

Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI

Published Online: Nov 30, 2018

Page range: 262 - 271

Received: May 02, 2018

Accepted: Oct 29, 2018

DOI: https://doi.org/10.1515/msr-2018-0036

Keywords
Perfusion imaging, contrast agents, brain tumors, DCE-MRI, DSC-MRI

© 2018 Ondřej Macíček et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI

Published Online: Nov 30, 2018

Page range: 262 - 271

Received: May 02, 2018

Accepted: Oct 29, 2018

DOI: https://doi.org/10.1515/msr-2018-0036

KeywordsPerfusion imaging, contrast agents, brain tumors, DCE-MRI, DSC-MRI

© 2018 Ondřej Macíček et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Perfusion imaging, contrast agents, brain tumors, DCE-MRI, DSC-MRI