<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> The aim of the research was to investigate the antiviral and immunoregulatory effects of saikosaponin A, saikosaponin D, Panax notoginseng saponins, notoginsenoside R1, and anemoside B4 saponins commonly found in Chinese herbal medicines.<bold>Material and Methods:</bold> control mice were challenged intramuscularly (im) with 0.2 mL of porcine circovirus 2 (PCV2) solution containing 107 TCID50 of the virus/mL. Mice of high-, middle-, and low-dose saponin groups were initially challenged im with 0.2 mL of PCV2 solution and three days later treated intraperitoneally (ip) with one of five saponins at one of three doses (10, 5, or 1 mg/kg b.w.). In the drug control group, mice were dosed ip with 10 mg/kg b.w. of a given saponin, and mice in a blank control group were administered the same volume of normal saline.<bold>Results:</bold> The results revealed that the saponins could reduce the incidence and severity of PCV2-induced immunopathological damage, <italic>e.g</italic>. body temperature elevation, weight loss, anaemia, and internal organ swelling. In addition, it was seen that the saponins could affect the immunoglobulin levels and protein absorption.<bold>Conclusion:</bold> The data suggested that the saponins might effectively regulate immune responses.</abstract>

Introduction: The aim of the research was to investigate the antiviral and immunoregulatory effects of saikosaponin A, saikosaponin D, Panax notoginseng saponins, notoginsenoside R1, and anemoside B4 saponins commonly found in Chinese herbal medicines.Material and Methods: control mice were challenged intramuscularly (im) with 0.2 mL of porcine circovirus 2 (PCV2) solution containing 107 TCID50 of the virus/mL. Mice of high-, middle-, and low-dose saponin groups were initially challenged im with 0.2 mL of PCV2 solution and three days later treated intraperitoneally (ip) with one of five saponins at one of three doses (10, 5, or 1 mg/kg b.w.). In the drug control group, mice were dosed ip with 10 mg/kg b.w. of a given saponin, and mice in a blank control group were administered the same volume of normal saline.Results: The results revealed that the saponins could reduce the incidence and severity of PCV2-induced immunopathological damage, e.g. body temperature elevation, weight loss, anaemia, and internal organ swelling. In addition, it was seen that the saponins could affect the immunoglobulin levels and protein absorption.Conclusion: The data suggested that the saponins might effectively regulate immune responses.

Antiviral and immunoregulatory role against PCV2 <italic>in vivo</italic> of Chinese herbal medicinal ingredients

Jiangsu Agri-animal Husbandry Vocational College

Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antiviral and immunoregulatory role against PCV2  of Chinese herbal medicinal ingredients

Introduction: The aim of the research was to investigate the antiviral and immunoregulatory effects of saikosaponin A, saikosaponin D, Panax notoginseng...

Antiviral and immunoregulatory role against PCV2 in vivo of Chinese herbal medicinal ingredients

Published Online: Dec 27, 2017

Page range: 405 - 410

Received: Jul 07, 2017

Accepted: Dec 04, 2017

DOI: https://doi.org/10.1515/jvetres-2017-0062

Keywords
porcine circovirus, saponins, antivirus properties, immune system

© 2017 Haifeng Yang et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antiviral and immunoregulatory role against PCV2 in vivo of Chinese herbal medicinal ingredients

Published Online: Dec 27, 2017

Page range: 405 - 410

Received: Jul 07, 2017

Accepted: Dec 04, 2017

DOI: https://doi.org/10.1515/jvetres-2017-0062

Keywordsporcine circovirus, saponins, antivirus properties, immune system

© 2017 Haifeng Yang et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
porcine circovirus, saponins, antivirus properties, immune system