<abstract xmlns="http://www.w3.org/1999/xhtml">The aim of the study was to assess the changes of blood parameters in 12 three-week-old Polish Merino sheep subjected to experimental jaagsiekte sheep retrovirus (JSRV) infection.<bold>Material and Methods:</bold> Haematological (WBC with leukocyte subpopulations: GRA, LYM, MID, and RBC, MCV, MCH, MCHC, HGB, HCT, PLT, and MPV) and biochemical blood parameters (acid/base balance, cation/anion content, and gasometry) were determined in blood samples collected one month after JSRV infection, then at four-week intervals for five consecutive months.<bold>Results:</bold> A decrease in RBC, HCT, MCV, PLT, MPV, and LYM values in comparison with controls was found in the last month of observation. On the other hand, at the same time, an increase in HGB, MCH, MCHC, WBC, MID, and GRA indices was observed. Moreover, at the end of experiment blood gasometric indices such as pCO2, HCO3, and tCO2, and Na and K ion concentrations were higher in the affected lambs than in the healthy animals. The pH values of the challenged animals exhibited less alkaline character than in the case of controls, which was associated with a decrease in O2% saturation. However, the majority of differences between JSRV inoculated and control groups was not statistically significant.<bold>Conclusion:</bold> The observed changes in the examined blood parameters can be considered as prodromal symptoms in the preclinical phase of adenocarcinoma development associated with JSRV infection.</abstract>

The aim of the study was to assess the changes of blood parameters in 12 three-week-old Polish Merino sheep subjected to experimental jaagsiekte sheep retrovirus (JSRV) infection.Material and Methods: Haematological (WBC with leukocyte subpopulations: GRA, LYM, MID, and RBC, MCV, MCH, MCHC, HGB, HCT, PLT, and MPV) and biochemical blood parameters (acid/base balance, cation/anion content, and gasometry) were determined in blood samples collected one month after JSRV infection, then at four-week intervals for five consecutive months.Results: A decrease in RBC, HCT, MCV, PLT, MPV, and LYM values in comparison with controls was found in the last month of observation. On the other hand, at the same time, an increase in HGB, MCH, MCHC, WBC, MID, and GRA indices was observed. Moreover, at the end of experiment blood gasometric indices such as pCO2, HCO3, and tCO2, and Na and K ion concentrations were higher in the affected lambs than in the healthy animals. The pH values of the challenged animals exhibited less alkaline character than in the case of controls, which was associated with a decrease in O2% saturation. However, the majority of differences between JSRV inoculated and control groups was not statistically significant.Conclusion: The observed changes in the examined blood parameters can be considered as prodromal symptoms in the preclinical phase of adenocarcinoma development associated with JSRV infection.

Changes in blood parameters induced by experimental jaagsiekte sheep retrovirus infection

Department of Cattle and Sheep Diseases, National Veterinary Research Institute, 24-100 Pulawy,

Sub-Department of Internal Diseases of Farm Animals and Horses, Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612 Lublin,

Department of Pathology, National Veterinary Research Institute, 24-100 Pulawy,

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The aim of the study was to assess the changes of blood parameters in 12 three-week-old Polish Merino sheep subjected to experimental jaagsiekte sheep...

Changes in blood parameters induced by experimental jaagsiekte sheep retrovirus infection

Published Online: Sep 23, 2016

Page range: 245 - 251

Received: Jun 03, 2016

Accepted: Sep 06, 2016

DOI: https://doi.org/10.1515/jvetres-2016-0037

Keywords
sheep, jaagsiekte sheep retrovirus, adenocarcinoma, haematological and biochemical parameters

© 2016 Katarzyna Dudek et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Changes in blood parameters induced by experimental jaagsiekte sheep retrovirus infection

Published Online: Sep 23, 2016

Page range: 245 - 251

Received: Jun 03, 2016

Accepted: Sep 06, 2016

DOI: https://doi.org/10.1515/jvetres-2016-0037

Keywordssheep, jaagsiekte sheep retrovirus, adenocarcinoma, haematological and biochemical parameters

© 2016 Katarzyna Dudek et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
sheep, jaagsiekte sheep retrovirus, adenocarcinoma, haematological and biochemical parameters