<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> Coronary artery disease (CAD) is the leading cause of death worldwide and is associated with a significant socio-economic impact. In many cases, patients are treated with implanted coronary stents that carry a significant risk for reobstruction. The <bold>aim</bold> of our study was to evaluate the importance of coronary computed tomography angiography (CCTA) in evaluating the significance of in-stent restenosis lesions and for establishing the indication for reintervention in these cases.<bold>Materials and methods:</bold> We evaluated 25 patients who underwent CCTA examination. We determined the contrast density, expressed in Hounsfield units at two levels, proximal and distal to the stent.<bold>Results:</bold> There were no statistically significant differences between the study groups in terms of gender (41.17% females in Group 1 vs. 37.5% in Group 2, p = 1), presence of hypertension (41.17% in Group 1 vs. 62.5% in Group 2, p = 0.31), smoking status (41.17% in Group 1 vs. 37.5% in Group 2, p = 0.31), incidence of dyslipidemia (47.05% vs. 50%, p = 1) and diabetes mellitus (35.29% vs. 0%, p = 0.31). However, the age of the study population was significantly higher in the groups with significant ISR (58.94 ± 8.35 vs. 47.25 ± 11.2, p = 0.02). Patients who showed significant angiographic in-stent stenosis (more than 70%) were found to have a higher transluminal attenuation gradient, compared with those with less severe lesions (14.5 ± 5.4 vs. 5.14 ± 2.4, p = 0.02).<bold>Conclusions:</bold> The transluminal attenuation gradient, assessed by CCTA is a non-invasive-derived parameter that can help the clinician to determine the right time for revascularization in case of in-stent restenosis.</abstract>

Introduction: Coronary artery disease (CAD) is the leading cause of death worldwide and is associated with a significant socio-economic impact. In many cases, patients are treated with implanted coronary stents that carry a significant risk for reobstruction. The aim of our study was to evaluate the importance of coronary computed tomography angiography (CCTA) in evaluating the significance of in-stent restenosis lesions and for establishing the indication for reintervention in these cases.Materials and methods: We evaluated 25 patients who underwent CCTA examination. We determined the contrast density, expressed in Hounsfield units at two levels, proximal and distal to the stent.Results: There were no statistically significant differences between the study groups in terms of gender (41.17% females in Group 1 vs. 37.5% in Group 2, p = 1), presence of hypertension (41.17% in Group 1 vs. 62.5% in Group 2, p = 0.31), smoking status (41.17% in Group 1 vs. 37.5% in Group 2, p = 0.31), incidence of dyslipidemia (47.05% vs. 50%, p = 1) and diabetes mellitus (35.29% vs. 0%, p = 0.31). However, the age of the study population was significantly higher in the groups with significant ISR (58.94 ± 8.35 vs. 47.25 ± 11.2, p = 0.02). Patients who showed significant angiographic in-stent stenosis (more than 70%) were found to have a higher transluminal attenuation gradient, compared with those with less severe lesions (14.5 ± 5.4 vs. 5.14 ± 2.4, p = 0.02).Conclusions: The transluminal attenuation gradient, assessed by CCTA is a non-invasive-derived parameter that can help the clinician to determine the right time for revascularization in case of in-stent restenosis.

Correlations Between the Contrast Density Gradient along the Coronary Stents and Functional Significance of In-stent Restenosis

Clinic of Cardiology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Center of Advanced Research in Multimodality Cardiac Imaging, Cardio Med Medical Center, Tîrgu Mureș, Romania

Clinic of Radiology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: Coronary artery disease (CAD) is the leading cause of death worldwide and is associated with a significant socio-economic impact. In many cases,...

Correlations Between the Contrast Density Gradient along the Coronary Stents and Functional Significance of In-stent Restenosis

Published Online: Jul 06, 2016

Page range: 79 - 82

Received: Apr 01, 2016

Accepted: May 19, 2016

DOI: https://doi.org/10.1515/jim-2016-0015

Keywords
in-stent restenosis, CT coronary angiography, transluminal attenuation gradient

© 2016 Marius Orzan et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Correlations Between the Contrast Density Gradient along the Coronary Stents and Functional Significance of In-stent Restenosis

Published Online: Jul 06, 2016

Page range: 79 - 82

Received: Apr 01, 2016

Accepted: May 19, 2016

DOI: https://doi.org/10.1515/jim-2016-0015

Keywordsin-stent restenosis, CT coronary angiography, transluminal attenuation gradient

© 2016 Marius Orzan et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
in-stent restenosis, CT coronary angiography, transluminal attenuation gradient