<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Infective endocarditis (IE) is an infection of the endocardium and/or heart valves with the formation of a thrombus and secondary damage of the involved tissue, with significant mortality and severe complications. The prevention of bacterial endocarditis is of great controversy. Antimicrobial prophylaxis is usable in the prevention of endocarditis by killing bacteria before or after their extension to the damaged endocardium. No human studies offer strong evidence to support the efficacy of antibiotic prophylaxis so far, thus it could be potentially dangerous. Therefore, the European Society of Cardiology (ESC) may need to reconsider and update the previous guidelines with the proposal of reducing the prophylactic approach of IE. The 2015 Task Force recommends prophylaxis for highest risk patients undergoing highest risk procedures, focused on prevention rather than prophylaxis of IE, especially in nosocomial endocarditis.</p></abstract>

Infective endocarditis (IE) is an infection of the endocardium and/or heart valves with the formation of a thrombus and secondary damage of the involved tissue, with significant mortality and severe complications. The prevention of bacterial endocarditis is of great controversy. Antimicrobial prophylaxis is usable in the prevention of endocarditis by killing bacteria before or after their extension to the damaged endocardium. No human studies offer strong evidence to support the efficacy of antibiotic prophylaxis so far, thus it could be potentially dangerous. Therefore, the European Society of Cardiology (ESC) may need to reconsider and update the previous guidelines with the proposal of reducing the prophylactic approach of IE. The 2015 Task Force recommends prophylaxis for highest risk patients undergoing highest risk procedures, focused on prevention rather than prophylaxis of IE, especially in nosocomial endocarditis.

Infective Endocarditis in Children — New Approach in Antimicrobial Prophylaxis

Clinic of Pediatric Cardiology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Infective endocarditis (IE) is an infection of the endocardium and/or heart valves with the formation of a thrombus and secondary damage of the involved...

Infective Endocarditis in Children — New Approach in Antimicrobial Prophylaxis

Published Online: Jul 06, 2016

Page range: 9 - 11

Received: Mar 31, 2016

Accepted: May 17, 2016

DOI: https://doi.org/10.1515/jim-2016-0003

Keywords
infective endocarditis, prophylaxis, antibiotics

© 2016 Rodica Togănel, published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Infective Endocarditis in Children — New Approach in Antimicrobial Prophylaxis

Published Online: Jul 06, 2016

Page range: 9 - 11

Received: Mar 31, 2016

Accepted: May 17, 2016

DOI: https://doi.org/10.1515/jim-2016-0003

Keywordsinfective endocarditis, prophylaxis, antibiotics

© 2016 Rodica Togănel, published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
infective endocarditis, prophylaxis, antibiotics