Clinical Update. Clinical Presentations of Pulmonary Embolism in the Emergency Department

1. Heit JA, Silverstein MD, Mohr DN. The epidemiology of venous thromboembolism in the community. Thromb Haemost. 2001;86:452-463.10.1055/s-0037-1616243Search in Google Scholar

2. Jiménez Castro D, Sueiro A, Díaz G, et al. Prognostic significance of delays in diagnosis of pulmonary embolism. Thromb Res. 2007;121:153-158. doi: 10.1016/j.thromres.2007.03.028.Search in Google Scholar

3. De Perrot M, Granton J, Fadel E. Pulmonary hypertension after pulmonary emboli: an underrecognized condition. CMAJ : Canadian Medical Association Journal. 2006;174:1706.10.1503/cmaj.051646147182616754894Search in Google Scholar

4. Kopcke D, Harryman O, Benbow EW, Hay C, Chalmers N. Mortality from pulmonary embolism is decreasing in hospital patients. Journal of the Royal Society of Medicine. 2011;104:327-331. doi: 10.1258/jrsm.2011.100395.Search in Google Scholar

5. Aujesky D, Jimenez D, Mor MK, et al. Weekend versus weekday admission and mortality after acute pulmonary embolism. Circulation. 2009;119:962-968. doi: 10.1161/CIRCULATIONAHA.108.824292.Search in Google Scholar

6. Laporte S, Mismetti P, Decousus H, et al. Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry. Circulation. 2008;117:1711-1716. doi: 10.1161/CIRCULATIONAHA.107.726232.Search in Google Scholar

7. Charlebois D. Early recognition of pulmonary embolism: the key to lowering mortality. J Cardiovasc Nurs. 2005;20:254-259.10.1097/00005082-200507000-0001016000912Open DOISearch in Google Scholar

8. Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2014;35:3033-3069, 3069a-3069k. doi: 10.1093/eurheartj/ehu479.Search in Google Scholar

9. van Belle A, Buller HR, Huisman MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA. 2006;295:172-179. doi: 10.1001/jama.295.2.172.Search in Google Scholar

10. Janata K, Holzer M, Domanovits H, et al. Mortality of patients with pulmonary embolism. Wien Klin Wochenschr. 2002;114:766-772.Search in Google Scholar

11. Opincariu D, Mester A, Rațiu M, et al. Factors associated with one-year mortality in patients with acute pulmonary embolism. Journal of Cardiovascular Emergencies. 2016;2:63-70. doi: 10.1515/jce-2016-0010.Search in Google Scholar

12. McCaig LF, Burt CW. National hospital ambulatory medical care survey: 2002 emergency department summary. Adv Data. 2004;340:1-34.Search in Google Scholar

13. Roy PM, Meyer G, Vielle B, et al. Appropriateness of diagnostic management and outcomes of suspected pulmonary embolism. Ann Intern Med. 2006;144:157-164.10.7326/0003-4819-144-3-200602070-0000316461959Search in Google Scholar

14. Kline JA, Hernandez-Nino J, Jones AE, et al. Prospective study of the clinical features and outcomes of emergency department patients with delayed diagnosis of pulmonary embolism. Acad Emerg Med. 2007;14:592-598. doi: 10.1197/j.aem.2007.03.1356.Search in Google Scholar

15. Guo DJ, Zhao C, Zou YD, et al. Values of the Wells and revised Geneva scores combined with D-dimer in diagnosing elderly pulmonary embolism patients. Chin Med J (Engl). 2015;128:1052-1057. doi: 10.4103/0366-6999.155085.Search in Google Scholar

16. Di Marca S, Cilia C, Campagna A, et al. Comparison of Wells and Revised Geneva Rule to Assess Pretest Probability of Pulmonary Embolism in High-Risk Hospitalized Elderly Adults. J Am Geriatr Soc. 2015;63:1091-1097. doi: 10.1111/jgs.13459.Search in Google Scholar

17. Buchanan I, Teeples T, Carlson M, et al. Pulmonary Embolism Testing Among Emergency Department Patients Who Are Pulmonary Embolism Rule-out Criteria Negative. Acad Emerg Med. 2017. doi: 10.1111/acem.13270. [Epub ahead of print]Search in Google Scholar

18. de la Mora Cervantes R, Dennie C. Triple rule-out cardiaccomputed tomography: is it finally a reality? Minerva Cardioangiol. 2017;65:225-234. doi: 10.23736/S0026-4725.16.04272-9. Search in Google Scholar

19. Dobra M, Bordi L, Nyulas T, et al. Computed Tomography - an Emerging Tool for Triple Rule-Out in the Emergency Department. A Review. Journal of Cardiovascular Emergencies. 2017;3:36-40. doi: 10.1515/jce-2017-0005.Search in Google Scholar

20. Sawyer KN, Shah P, Qu L, et al. Triple Rule Out versus CT Angiogram Plus Stress Test for Evaluation of Chest Pain in the Emergency Department. West J Emerg Med. 2015;16:677-682. doi: 10.5811/westjem.2015.6.25958.Search in Google Scholar

21. Chae MK, Kim EK, Jung KY, et al. Triple rule-out computed tomography for risk stratification of patients with acute chest pain. J Cardiovasc Comput Tomogr. 2016;10:291-300. doi: 10.1016/j.jcct.2016.06.002.Search in Google Scholar

22. Le Gal G, Righini M, Roy PM, Sanchez O, Aujesky D, Bounameaux H, Perrier A. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med. 2006;144:165-171.10.7326/0003-4819-144-3-200602070-0000416461960Search in Google Scholar

23. Woolf SH, Grol R, Hutchinson A, Eccles M, Grimshaw J. Clinical guidelines: Potential benefits, limitations, and harms of clinical guidelines. BMJ. 1999;318:527-530.10.1136/bmj.318.7182.527111497310024268Search in Google Scholar

24. Wicki J, Perneger T, Junod A, et al. Assessing clinical probability of the pulmonary embolism in the emergency ward: a simple score. Arch Intern Med. 2001;161:92-97.10.1001/archinte.161.1.9211146703Search in Google Scholar

25. Douma RA, Mos IC, Erkens PM, et al. Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism. A prospective cohort study. Ann Intern Med. 2011;154:709-718. doi: 10.7326/0003-4819-154-11-201106070-00002.Search in Google Scholar

26. Wells PS, Anderson DR, Rodger M, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost. 2000;83:416-420.10.1055/s-0037-1613830Search in Google Scholar

27. El Wahsh RA, Agha MA. Clinical probability of pulmonary embolism: Comparison of different scoring systems. In Egyptian Journal of Chest Diseases and Tuberculosis. 2012; 61:419-424. doi: 10.1016/j.ejcdt.2012.07.002.Search in Google Scholar

28. Miniati M, Bottai M, Monti S. Simple and accurate prediction of the clinical probability of pulmonary embolism. Am J Respir Crit Care Med. 2008;178:290-294. doi: 10.1164/rccm.200802-207OC.Search in Google Scholar

29. Lucassen W, Geersing G, Erkens PM, et al. Clinical Decision Rules for Excluding Pulmonary Embolism: A Meta-analysis. Ann Intern Med. 2011;155:448-460. doi: 10.7326/0003-4819-155-7-201110040-00007.Search in Google Scholar

30. Aujesky D, Roy PM, Le Manach CP, et al. Validation of a model to predict adverse outcomes in patients with pulmonary embolism. Eur Heart J. 2006;27:476-481.10.1093/eurheartj/ehi58816207738Open DOISearch in Google Scholar

31. Spirk D, Aujesky D, Husmann M, et al. Cardiac troponin testing and the simplified Pulmonary Embolism Severity Index. The SWIss Venous Thrombo Embolism Registry (SWIVTER). Thromb Haemost. 2011;106:978-984. doi: 10.1160/TH11-06-0371.Search in Google Scholar

32. Prandoni P, Lensing AWA, Prins MH, et al. Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope. N Engl J Med. 2016;375:1524-1531. doi: 10.1056/ NEJMoa1602172.Search in Google Scholar

33. Oqab Z, Ganshorn H, Sheldon R. Prevalence of pulmonary embolism in patients presenting with syncope. A systematic review and meta-analysis. Am J Emerg Med. 2017;pii:S0735-6757(17)30740-4. doi: 10.1016/j.ajem.2017.09.015. [Epub ahead of print]Search in Google Scholar

34. Frizell A, Fogel N, Steenblik J, et al. Prevalence of pulmonary embolism in patients presenting to the emergency department with syncope. Am J Emerg Med. 2017;pii:S0735-6757(17)30639-3. doi: 10.1016/j.ajem.2017.07.090. [Epub ahead of print]Search in Google Scholar

35. Tripodi A, Chantarangkul V, Clerici M, Negri B, Galli M, Mannucci PM. Laboratory control of oral anticoagulant treatment by the INR system in patients with the antiphospholipid syndrome and lupus anticoagulant. Results of a collaborative study involving nine commercial thromboplastins. Br J Haematol. 2001;115:672-678.10.1046/j.1365-2141.2001.03178.x11736953Search in Google Scholar

36. Asherson RA, Piette JC. The catastrophic antiphospholipid syndrome: acute multiorgan failure associated with antiphospholipid antibodies: a review of 31 patients. Lupus. 1996;5:414-417.10.1177/0961203396005005168902772Open DOISearch in Google Scholar

37. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb Haemost. 2006;4:295-306. doi: 10.1111/j.1538-7836.2006.01753.x.Search in Google Scholar

38. Gorki H, Malinovski V, Stanbridge RDL. The antiphospholipid syndrome and heart valve surgery. Eur J CardioThorac Surg. 2008;33:168-181. doi: 10.1016/j.ejcts.2007.11.004. Search in Google Scholar

39. Cervera R, Serrano R, Pons-Estel GJ, et al. Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicenter prospective study of 1,000 patients. Ann Rheum Dis. 2015;74:1011-1018. doi: 10.1136/annrheumdis-2013-204838.Search in Google Scholar

40. Negrini S, Pappalardo F, Murdaca G, Indiveri F, Puppo F. The antiphospholipid syndrome: from pathophysiology to treatment. Clin Exp Med. 2017;17:257-267. doi: 10.1007/s10238-016-0430-5.Search in Google Scholar

41. Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med. 2004;10:1222-1226.10.1038/nm112115489858Search in Google Scholar

42. Gex G, Gerstel E, Righini M, et al. Is atrial fibrillation associated with pulmonary embolism? J Thromb Haemost. 2012;10:347-351. Search in Google Scholar

43. Bikdeli B, Abou Ziki MD, Lip GY. Pulmonary Embolism and Atrial Fibrillation: Two Sides of the Same Coin? A Systematic Review. Semin Thromb Hemost. 2017. doi: 10.1055/s-0036-1598005. [Epub ahead of print]Search in Google Scholar