<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Sepsis is an injurious systemic host response to infection, which can often lead to septic shock and death. Recently, the immune-pathogenesis and genomics of sepsis have become a research topic focusing on the establishment of diagnostic and prognostic biomarkers. As yet, none have been identified as having the necessary specificity to be used independently of other factors in this respect. However the accumulation of current evidence regarding genetic variations, especially the single nucleotide polymorphisms (SNPs) of cytokines and other innate immunity determinants, partially explains the susceptibility and individual differences of patients with regard to the evolution of sepsis. This article outlines the role of genetic variation of some serum proteins which have the potential to be used as biomarker values in evaluating sepsis susceptibility and the progression of the condition.</p></abstract>

Sepsis is an injurious systemic host response to infection, which can often lead to septic shock and death. Recently, the immune-pathogenesis and genomics of sepsis have become a research topic focusing on the establishment of diagnostic and prognostic biomarkers. As yet, none have been identified as having the necessary specificity to be used independently of other factors in this respect. However the accumulation of current evidence regarding genetic variations, especially the single nucleotide polymorphisms (SNPs) of cytokines and other innate immunity determinants, partially explains the susceptibility and individual differences of patients with regard to the evolution of sepsis. This article outlines the role of genetic variation of some serum proteins which have the potential to be used as biomarker values in evaluating sepsis susceptibility and the progression of the condition.

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Infectious Diseases Clinic, University of Medicine and Pharmacy Tirgu Mures,

Discipline of Pathophysiology, University of Medicine and Pharmacy Tirgu Mures,

University of Washington, Medical Center, Seattle,

Anesthesiology and Intensive Care Clinic, University of Medicine and Pharmacy Tirgu Mures,

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sepsis is an injurious systemic host response to infection, which can often lead to septic shock and death. Recently, the immune-pathogenesis and genomics of...

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Published Online: Feb 18, 2017

Page range: 5 - 11

Received: Dec 01, 2016

Accepted: Jan 20, 2017

DOI: https://doi.org/10.1515/jccm-2017-0001

Keywords
sepsis, biomarkers, cytokines, cell receptors, genes

© 2017 Anca Meda Georgescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Published Online: Feb 18, 2017

Page range: 5 - 11

Received: Dec 01, 2016

Accepted: Jan 20, 2017

DOI: https://doi.org/10.1515/jccm-2017-0001

Keywordssepsis, biomarkers, cytokines, cell receptors, genes

© 2017 Anca Meda Georgescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
sepsis, biomarkers, cytokines, cell receptors, genes