<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Systemic inflammatory activation in sepsis often leads to coagulation activation, but the relationship is bilateral, as coagulation also modulates the inflammatory response. This close associate has significant consequences for the pathogenesis of microvascular thrombosis and organ dysfunction in sepsis. While coagulation activation can be beneficial for immune defense, it can also be detrimental once it becomes widespread and uncontrolled. The knowledge of the pathophysiologic mechanisms involved in the interaction between infection and coagulation may lead to the better timing for the administration of targeted antithrombotic therapies in septic patients. This brief review highlights the pathophysiologic pathways leading to the prothrombotic state in sepsis and the mechanisms that play a role in the interaction between infection and coagulation.</p></abstract>

Systemic inflammatory activation in sepsis often leads to coagulation activation, but the relationship is bilateral, as coagulation also modulates the inflammatory response. This close associate has significant consequences for the pathogenesis of microvascular thrombosis and organ dysfunction in sepsis. While coagulation activation can be beneficial for immune defense, it can also be detrimental once it becomes widespread and uncontrolled. The knowledge of the pathophysiologic mechanisms involved in the interaction between infection and coagulation may lead to the better timing for the administration of targeted antithrombotic therapies in septic patients. This brief review highlights the pathophysiologic pathways leading to the prothrombotic state in sepsis and the mechanisms that play a role in the interaction between infection and coagulation.

Sepsis-Associated Coagulopathy

Department of Anesthesiology and Intensive Care III, Fundeni Clinical Institute, Bucharest,

University of Medicine and Pharmacy “Carol Davila”, Bucharest,

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Sepsis-Associated Coagulopathy"}

Systemic inflammatory activation in sepsis often leads to coagulation activation, but the relationship is bilateral, as coagulation also modulates the...

Sepsis-Associated Coagulopathy

Published Online: Nov 08, 2016

Page range: 156 - 163

Received: Aug 02, 2016

Accepted: Sep 29, 2016

DOI: https://doi.org/10.1515/jccm-2016-0024

Keywords
sepsis, coagulopathy, thrombosis

© 2016 Ecaterina Scarlatescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sepsis-Associated Coagulopathy

Published Online: Nov 08, 2016

Page range: 156 - 163

Received: Aug 02, 2016

Accepted: Sep 29, 2016

DOI: https://doi.org/10.1515/jccm-2016-0024

Keywordssepsis, coagulopathy, thrombosis

© 2016 Ecaterina Scarlatescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
sepsis, coagulopathy, thrombosis