<abstract xmlns="http://www.w3.org/1999/xhtml"> Angiooedema is a local and self-limiting swelling of the subcutaneous and sub mucosal tissues, produced by vasoactive peptides that temporary increase the vascular permeability.It is recognized that recurrent angiooedema exposes patients to the risk of fatalities and reduced quality of life, being in some circumstances associated with a critical condition.Angiooedema can occur with or without wheals. The first symptom is urticaria, the second is a distinct nosologic entity. In absence of an identifiable cause, recurrent angiooedema without wheals can be defined as idiopathic and marked“idiopathic histaminergic angiooedema” when it is responsive to anti histamine treatment, and “idiopathic non-histaminergic angiooedema” when it is not. Furthermore, idiopathic non-histaminergic angiooedema can be diagnosed as hereditary or sporadic by family history.In this review, we summarize the approaches to diagnose and treat different forms of idiopathic angiooedema.</abstract>

Angiooedema is a local and self-limiting swelling of the subcutaneous and sub mucosal tissues, produced by vasoactive peptides that temporary increase the vascular permeability.It is recognized that recurrent angiooedema exposes patients to the risk of fatalities and reduced quality of life, being in some circumstances associated with a critical condition.Angiooedema can occur with or without wheals. The first symptom is urticaria, the second is a distinct nosologic entity. In absence of an identifiable cause, recurrent angiooedema without wheals can be defined as idiopathic and marked“idiopathic histaminergic angiooedema” when it is responsive to anti histamine treatment, and “idiopathic non-histaminergic angiooedema” when it is not. Furthermore, idiopathic non-histaminergic angiooedema can be diagnosed as hereditary or sporadic by family history.In this review, we summarize the approaches to diagnose and treat different forms of idiopathic angiooedema.

Differential diagnosis and management issues of idiopathic angiooedema and their resolution

Department of Biomedical and Clinical Sciences “L. Sacco” University of Milan and Ospedale L. Sacco Milan, Italy

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Angiooedema is a local and self-limiting swelling of the subcutaneous and sub mucosal tissues, produced by vasoactive peptides that temporary increase the...

Differential diagnosis and management issues of idiopathic angiooedema and their resolution

Published Online: Jun 05, 2015

Page range: 55 - 60

Received: Mar 10, 2015

Accepted: Apr 18, 2015

DOI: https://doi.org/10.1515/jccm-2015-0008

Keywords
angiooedema, idiopathic, C1 inhibitor, factor XII, bradykinin, tranexamic acid

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Differential diagnosis and management issues of idiopathic angiooedema and their resolution

Published Online: Jun 05, 2015

Page range: 55 - 60

Received: Mar 10, 2015

Accepted: Apr 18, 2015

DOI: https://doi.org/10.1515/jccm-2015-0008

Keywordsangiooedema, idiopathic, C1 inhibitor, factor XII, bradykinin, tranexamic acid

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
angiooedema, idiopathic, C1 inhibitor, factor XII, bradykinin, tranexamic acid