<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Immune thrombocytopenia (ІTP) is one of the most common causes of clinically overt hemorrhage. Despite the progress made in recent years in clarifying the pathogenesis of the disease, the exact unlockmechanisms still remain unclear. The aim of the study was to correlate the oxidative stress markers and the severity of immune thrombocytopenia in adults and to investigate their predictive value of transforming the acute formof ITPinto chronicІTP.We studiedatotal of 58 subjects (14 patients with newly diagnosedІTP, 13 patients with chronic form ofІTR, and 31 controls). The plasma levels of human pantetheinase ( vanin-1) and lipid hydroperoxides were measured using commercial assay kits.We found that the form of the disease was not significantly related to the plasma vanin-1 levels (p=0.120). Asignificant difference in the vanin-1concentrations was observed between newly diagnosed IPTand the controls (p=0.046). Further studies with larger and more homogenous groups of patients and including more indicators of oxidative stress are needed to be able to draw statistically valid conclusions about the role of oxidative biomarkers in diagnosing and treatment ofІTP.</p></abstract>

Immune thrombocytopenia (ІTP) is one of the most common causes of clinically overt hemorrhage. Despite the progress made in recent years in clarifying the pathogenesis of the disease, the exact unlockmechanisms still remain unclear. The aim of the study was to correlate the oxidative stress markers and the severity of immune thrombocytopenia in adults and to investigate their predictive value of transforming the acute formof ITPinto chronicІTP.We studiedatotal of 58 subjects (14 patients with newly diagnosedІTP, 13 patients with chronic form ofІTR, and 31 controls). The plasma levels of human pantetheinase ( vanin-1) and lipid hydroperoxides were measured using commercial assay kits.We found that the form of the disease was not significantly related to the plasma vanin-1 levels (p=0.120). Asignificant difference in the vanin-1concentrations was observed between newly diagnosed IPTand the controls (p=0.046). Further studies with larger and more homogenous groups of patients and including more indicators of oxidative stress are needed to be able to draw statistically valid conclusions about the role of oxidative biomarkers in diagnosing and treatment ofІTP.

Original Article. Diagnostic and Prognostic Potential of Oxidative Stress Markers in Adults with Immune Thrombocytopenia

Clinic of Hematology, University Hospital, 8a, Georgi Kochev Blvd. Pleven, 5800,

Department of Physics and Biophysics, Medical University – Pleven,

Division of Biology, Medical University – Pleven,

Department of Nephrology, Haematology and Gastroenterology, Division of Haematology, Medical University – Pleven,

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Immune thrombocytopenia (ІTP) is one of the most common causes of clinically overt hemorrhage. Despite the progress made in recent years in clarifying the...

Original Article. Diagnostic and Prognostic Potential of Oxidative Stress Markers in Adults with Immune Thrombocytopenia

Published Online: Apr 06, 2017

Page range: 121 - 125

Received: Nov 21, 2016

Accepted: Dec 20, 2016

DOI: https://doi.org/10.1515/jbcr-2016-0017

Keywords
immune thrombocytopenia, oxidative stress, vanin-1, lipid hydroperoxides

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Original Article. Diagnostic and Prognostic Potential of Oxidative Stress Markers in Adults with Immune Thrombocytopenia

Published Online: Apr 06, 2017

Page range: 121 - 125

Received: Nov 21, 2016

Accepted: Dec 20, 2016

DOI: https://doi.org/10.1515/jbcr-2016-0017

Keywordsimmune thrombocytopenia, oxidative stress, vanin-1, lipid hydroperoxides

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
immune thrombocytopenia, oxidative stress, vanin-1, lipid hydroperoxides