<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Honeybee collected pollen exhibits high nutritional and pharmaceutical benefits for the human diet and medicine. Pollen’s antioxidant, anti-ageing, anti-inflammatory, anti-atherosclerosis, and cardioprotective activity, depending on the floral origin, are well known. Recent studies proposed that pollen may also be an excellent cancer-fighting candidate, as pollen harbours high amounts of phenolic substances. In our study, Filipendula ulmaria pollen (bee collected) was methanol-water extracted and used to verify its in vitro pharmacological activities on C26 mice cancer tumour cells. Three different concentrations of the extract were tested in antitumour assays. Monitoring was done after 6, 12, 24, and 48 hours. Promising results were obtained for antiproliferative and apoptotic activity of the pollen extracts, with high efficiency for the highest concentration (1 mg/mL). For both activities, time and concentration-dependent effects were observed. Pollen extracts or bee collected pollen has a high potential as an antitumour agent for use in human medicine, because they are both rich in bioactive compounds.</p></abstract>

Honeybee collected pollen exhibits high nutritional and pharmaceutical benefits for the human diet and medicine. Pollen’s antioxidant, anti-ageing, anti-inflammatory, anti-atherosclerosis, and cardioprotective activity, depending on the floral origin, are well known. Recent studies proposed that pollen may also be an excellent cancer-fighting candidate, as pollen harbours high amounts of phenolic substances. In our study, Filipendula ulmaria pollen (bee collected) was methanol-water extracted and used to verify its in vitro pharmacological activities on C26 mice cancer tumour cells. Three different concentrations of the extract were tested in antitumour assays. Monitoring was done after 6, 12, 24, and 48 hours. Promising results were obtained for antiproliferative and apoptotic activity of the pollen extracts, with high efficiency for the highest concentration (1 mg/mL). For both activities, time and concentration-dependent effects were observed. Pollen extracts or bee collected pollen has a high potential as an antitumour agent for use in human medicine, because they are both rich in bioactive compounds.

Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells

Department of Apiculture and Sericulture, Faculty of Animal Breeding and Biotechnology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania

Department of Biotechnologies, Faculty of Animal Breeding and Biotechnology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania

Molecular Ecology, Institute for Biology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

Journal of Apicultural Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Honeybee collected pollen exhibits high nutritional and pharmaceutical benefits for the human diet and medicine. Pollen’s antioxidant, anti-ageing,...

Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells

Published Online: Jun 03, 2016

Page range: 135 - 144

Received: Mar 09, 2016

Accepted: May 12, 2016

DOI: https://doi.org/10.1515/jas-2016-0014

Keywords
Antioxidant activity, antitumour activity, apoptosis, bioactive compound, Filipendula ulmaria, floral origin

© by Silvio Erler

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells

Published Online: Jun 03, 2016

Page range: 135 - 144

Received: Mar 09, 2016

Accepted: May 12, 2016

DOI: https://doi.org/10.1515/jas-2016-0014

KeywordsAntioxidant activity, antitumour activity, apoptosis, bioactive compound, Filipendula ulmaria, floral origin

© by Silvio Erler

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Antioxidant activity, antitumour activity, apoptosis, bioactive compound, Filipendula ulmaria, floral origin