Open Access

Heavy metal intoxication compromises the host cytokine response in Ascaris Suum model infection


Cite

Behm, C.A., Ovington, K.S. (2000): The role of eosinophils in parasitic helminth infections: insights from genetically modified mice. Parasitol. Today, 16(5): 202 – 209. DOI: 10.1016/S0169-4758(99)01620-8BehmCAOvingtonKS2000The role of eosinophils in parasitic helminth infections: insights from genetically modified miceParasitol. Today165202209DOI:10.1016/S0169-4758(99)01620-8Open DOISearch in Google Scholar

Betson, M., Nejsum, P., Bendall, R.P., Deb, R.M., Stothard, J.R. (2014): Molecular epidemiology of ascariasis: a global perspective on the transmission dynamics of Ascaris in people and pigs. J. Infect. Dis., 210(6): 932 – 941. DOI: 10.1093/infdis/jiu193BetsonMNejsumPBendallRPDebRMStothardJR2014Molecular epidemiology of ascariasis: a global perspective on the transmission dynamics of Ascaris in people and pigsJ. Infect. Dis.2106932941DOI:10.1093/infdis/jiu193Open DOISearch in Google Scholar

Boes, J., Eriksen, L., Nansen, P. (1998): Embryonation and infectivity of Ascaris suum eggs isolated from worms expelled by pigs treated with albendazole, pyrantel pamoate, ivermectin or piperazine dihydrochloride. Vet. Parasitol, 75(2–3): 181 – 190. DOI:10.1016/S0304-4017(97)00197-0BoesJEriksenLNansenP1998Embryonation and infectivity of Ascaris suum eggs isolated from worms expelled by pigs treated with albendazole, pyrantel pamoate, ivermectin or piperazine dihydrochlorideVet. Parasitol752–3181190DOI:10.1016/S0304-4017(97)00197-0Open DOISearch in Google Scholar

Broekhuizen, R., Grimble, R.F., Howell, W.M., Shale, D.J., Creutzberg, E.C., Wouters, E.F., Schols, A.M. (2005): Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta -511 single nucleotide polymorphism. Am. J. Clin. Nutr, 82(5): 1059 – 1064.BroekhuizenRGrimbleRFHowellWMShaleDJCreutzbergECWoutersEFScholsAM2005Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta -511 single nucleotide polymorphismAm. J. Clin. Nutr8251059106410.1093/ajcn/82.5.1059Search in Google Scholar

Cooper, P.J., Chico, M.E., Sandoval, C., Espinel, I., Guevara, A., Kennedy, M.W., Urban, J.F. Jr, Griffin, G.E.J., Nutman, T.B. Jr. (2000): Human infection with Ascaris lumbricoides is associated with a polarized cytokine response. J. Infect. Dis., 182(4): 1207 – 1213. DOI: 10.1086/315830CooperPJChicoMESandovalCEspinelIGuevaraAKennedyMWUrbanJFJRGriffinGEJNutmanTBJR2000Human infection with Ascaris lumbricoides is associated with a polarized cytokine responseJ. Infect. Dis.182412071213DOI:10.1086/315830Open DOISearch in Google Scholar

Dvorožňáková, E., Hurníková, Z., Kolodziej-Sobocińska, M. (2011): Development of cellular immune response of mice to infection with low doses of Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis larvae. Parasitol. Res. 108(1): 169 – 176. DOI: 10.1007/s00436-010-2049-xDvorožňákováEHurníkováZKolodziej-SobocińskaM2011Development of cellular immune response of mice to infection with low doses of Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis larvaeParasitol. Res.1081169176DOI:10.1007/s00436-010-2049-xOpen DOISearch in Google Scholar

Dvorožňáková, E., Jalčová, M. (2013): Cytokine response of mice to heavy metal intoxication and Ascaris suum infection. In: Cozma, V. (Ed.) 11th European Multicolloquium of Parasitology (EMOP), 25-29 July, 2012, Cluj Napoca, Romania. Medimond s.r.l., Bologna, Italy (ISBN 978-88-7587-669-2), pp. 25 –27DvorožňákováEJalčováM2013Cytokine response of mice to heavy metal intoxication and Ascaris suum infectionCozmaV11th European Multicolloquium of Parasitology (EMOP), 25-29 July, 2012, Cluj Napoca, RomaniaMedimond s.r.l.Bologna, ItalyISBN978-88-7587-669-22527Search in Google Scholar

El-Gharabawy, R. M., El-Maddah, E. I., Oreby, M. M., Salem, H. S., Ramadan, M. O. (2013): Immunotoxicity and pulmonary toxicity induced by paints in Egyptian painters. J. Immunotoxicol. 10(3): 270 – 278. DOI: 10.3109/1547691X.2012.714005El-GharabawyRMEl-MaddahEIOrebyMMSalemHSRamadanMO2013Immunotoxicity and pulmonary toxicity induced by paints in Egyptian paintersJ. Immunotoxicol103270278DOI:10.3109/1547691X.2012.714005Open DOISearch in Google Scholar

Flickinger, E. L., Nichols, J. D. (1990): Small mammal populations at hazardous waste disposal sites near Houston, Texas, USA. Environ. Pollut. 65(2): 169 – 180. DOI:10.1016/0269-7491(90)90182-CFlickingerELNicholsJD1990Small mammal populations at hazardous waste disposal sites near Houston, Texas, USAEnviron. Pollut652169180DOI:10.1016/0269-7491(90)90182-COpen DOISearch in Google Scholar

García-Lestón, J., Roma-Torres, J., Mayan, O., Schroecksnadel, S., Fuchs, D., Moreira, A. O., Pásaro, E., Méndez, J., Teixeira, J. P., Laffon, B. (2012): Assessment of immunotoxicity parameters in individuals occupationally exposed to lead. J. Toxicol. Environ. Health A 75(13–15): 807 – 818. DOI: 10.1080/15287394.2012.690327García-LestónJRoma-TorresJMayanOSchroecksnadelSFuchsDMoreiraAOPásaroEMéndezJTeixeiraJPLaffonB2012Assessment of immunotoxicity parameters in individuals occupationally exposed to leadJ. Toxicol. Environ. Health A7513–15807818DOI:10.1080/15287394.2012.69032722788368Open DOISearch in Google Scholar

Gardner, R. M., Nyland, J. F., Evans, S. L., Wang, S. B., Doyle, K. M., Crainiceanu, C. M., Silbergeld, E. K. (2009) Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ. Health Perspect. 117:1932 – 1938. DOI: 10.1289/ehp.0900855GardnerRMNylandJFEvansSLWangSBDoyleKMCrainiceanuCMSilbergeldEK2009Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitroEnviron. Health Perspect11719321938DOI:10.1289/ehp.0900855279946920049214Open DOISearch in Google Scholar

Gardner, R. M., Nyland, J. F., Silva, A. I., Ventura, A. M., De Souza, J. M., Silbergeld, E. K. (2010): Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: Across-sectional study. Environ. Res. 110: 345 – 354. DOI: 10.1016/j.envres.2010.02.001GardnerRMNylandJFSilvaAIVenturaAMDe SouzaJMSilbergeldEK2010Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: Across-sectional studyEnviron. Res110345354DOI:10.1016/j.envres.2010.02.001287322820176347Open DOISearch in Google Scholar

Gazzinelli-Guimarães, P. H., Gazzinelli-Guimarães, A. C., Silva, F. N., Mati, V. L., Dhom-Lemos, L. De C., Barbosa, F. S., Passos, L. S., Gaze, S., Carneiro, C. M., Bartholomeu, D. C., Bueno, L. L., Fujiwara, R. T. (2013): Parasitological and immunological aspects of early Ascaris spp. infection in mice. Int. J. Parasitol. 43:697 – 706. DOI: 10.1016/j.ijpara.2013.02.009Gazzinelli-GuimarãesPHGazzinelli-GuimarãesACSilvaFNMatiVLDhom-LemosLDeCBarbosaFSPassosLSGazeSCarneiroCMBartholomeuDCBuenoLLFujiwaraRT2013Parasitological and immunological aspects of early Ascaris spp. infection in miceInt. J. Parasitol43697706DOI:10.1016/j.ijpara.2013.02.00923665127Open DOISearch in Google Scholar

HančuĽák, J., Bobro, M., Brehuv, J., Slančo, P. (2005): Deposition of heavy metals from dust fallout in selected areas of Eastern Slovakia (In Slovak). Acta Montanistica Slovaca 10(1): 246 – 252HančuľákJBobroMBrehuvJSlančoP2005Deposition of heavy metals from dust fallout in selected areas of Eastern Slovakia (In Slovak)Acta Montanistica Slovaca101246252Search in Google Scholar

Hančuľák, J., Bobro, M., Šestinová, O., Brehuv, J., Slančo, P. (2006): Mercury in the surrounding of old mining loads of Rudňany and Merník (In Slovak). Acta Montanistica Slovaca 11(2): 295 – 299HančuľákJBobroMŠestinováOBrehuvJSlančoP2006Mercury in the surrounding of old mining loads of Rudňany and Merník (In Slovak)Acta Montanistica Slovaca112295299Search in Google Scholar

Hančuľák, J., Fedorová, E., Šestinová, O., Špaldon, T., Matik, M. (2011): Influence of iron ore works in Nižná Slaná on atmospheric deposition of heavy metals. Acta Montan. Slovaca 16(3): 220 – 228HančuľákJFedorováEŠestinováOŠpaldonTMatikM2011Influence of iron ore works in Nižná Slaná on atmospheric deposition of heavy metalsActa Montan. Slovaca163220228Search in Google Scholar

Hemdan, N. Y. A., Emmrich, F., Adham, K., Wichmann, G., Lehmann, I., El-Massry, A., Ghoneim, H., Lehmann, J., Sack, U. (2005): Dose-dependent modulation of the in vitro cytokine production of human immune compotent cells by lead salts. Toxicol. Sci. 86 (1): 75 – 83. DOI: 10.1093/toxsci/kfi177HemdanNY AEmmrichFAdhamKWichmannGLehmannIEl-MassryAGhoneimHLehmannJSackU2005Dose-dependent modulation of the in vitro cytokine production of human immune compotent cells by lead saltsToxicol. Sci.8617583DOI:10.1093/toxsci/kfi17715843504Open DOISearch in Google Scholar

Hemdan, N. Y. A., Emmrich, F., Sack, U., Wichmann, G., Lehmann, J., Adham, K., Lehmann, I. (2006): The in vitro immune modulation by cadmium depends on the way of cell activation. Toxicology 222(1– 2): 37 – 45. DOI: 10.1016/j.tox.2006.01.026HemdanNY AEmmrichFSackUWichmannGLehmannJAdhamKLehmannI2006The in vitro immune modulation by cadmium depends on the way of cell activationToxicology2221–23745DOI:10.1016/j.tox.2006.01.02616510232Open DOISearch in Google Scholar

Hemdan, N. Y. A., Lehmann, I., Wichmann, G., Lehmann, J., Emmrich, F., Sack, U. (2007): Immunomodulation by mercuric chloride in vitro: application of diferent cell activation pathways. Clin. Exp. Immunol. 148(2): 325 – 337. DOI: 10.1111/j.1365-2249.2007.03338.xHemdanNY ALehmannIWichmannGLehmannJEmmrichFSackU2007Immunomodulation by mercuric chloride in vitro: application of diferent cell activation pathwaysClin. Exp. Immunol1482325337DOI:10.1111/j.1365-2249.2007.03338.x186888217302730Open DOISearch in Google Scholar

Hemdan, N. Y., Abu El-Saad, A. M., Sack, U. (2013): The role of T helper (TH)17 cells as a double-edged sword in the interplay of infection and autoimmunity with a focus on xenobiotic-induced immunomodulation. Clin. Dev. Immunol. 2013: Article ID 374769, 13 pages. DOI: 10.1155/2013/374769.HemdanNYAbu El-SaadAMSackU2013The role of T helper (TH)17 cells as a double-edged sword in the interplay of infection and autoimmunity with a focus on xenobiotic-induced immunomodulationClin. Dev. Immunol2013Article ID 374769, 13 pagesDOI:10.1155/2013/374769378765224151516Open DOISearch in Google Scholar

Heo, Y., Lee, W. T., Lawrence, D. L. (1998): Differential effects of lead and cAMP on development and activities of Th1-and Th2-lymphocytes. Toxicol. Sci. 43(2): 172 – 185. DOI: 10.1093/toxsci/43.2.172HeoYLeeWTLawrenceDL1998Differential effects of lead and cAMP on development and activities of Th1-and Th2-lymphocytesToxicol. Sci.432172185DOI:10.1093/toxsci/43.2.172Open DOISearch in Google Scholar

Holland, C.V. (2009) Predisposition to ascariasis: patterns, mechanisms and implications. Parasitology 136(12): 1537 – 1547. DOI: 10.1017/S0031182009005952HollandCV2009Predisposition to ascariasis: patterns, mechanisms and implicationsParasitology1361215371547DOI:10.1017/S003118200900595219450374Open DOISearch in Google Scholar

Holmes, P., James, K. A., Levy, L. S. (2009): Is low-level environmental mercury exposure of concern to human health? Sci. Total Environ. 408(2): 171 – 182. DOI: 10.1016/j.scitotenv.2009.09.043.HolmesPJamesKALevyLS2009Is low-level environmental mercury exposure of concern to human health?Sci. Total Environ4082171182DOI:10.1016/j.scitotenv.2009.09.04319850321Open DOISearch in Google Scholar

Hu, H., Moller, G., Abedi-Valugerdi, M. (1999): Mechanism of mercury induced autoimmunity: both T helper 1- and T helper 2-type responses are involved. Immunology 96(3): 348 – 357. DOI: 10.1046/j.1365-2567.1999.00671.xHuHMollerGAbedi-ValugerdiM1999Mechanism of mercury induced autoimmunity: both T helper 1- and T helper 2-type responses are involvedImmunology963348357DOI:10.1046/j.1365-2567.1999.00671.x232677410233715Open DOISearch in Google Scholar

Jalčová, M., Dvorožňáková, E. (2014): Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suum. Helminthologia 51(3): 171 – 180. DOI: 10.2478/s11687-014-0226-7JalčováMDvorožňákováE2014Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suumHelminthologia513171180DOI:10.2478/s11687-014-0226-7Open DOISearch in Google Scholar

Järup, L. (2003): Hazards of heavy metal contamination. Br. Med. Bull. 68(1): 167 – 182. DOI: 10.1093/bmb/ldg032JärupL2003Hazards of heavy metal contaminationBr. Med. Bull.681167182DOI:10.1093/bmb/ldg03214757716Open DOISearch in Google Scholar

Jomova, K., Valko, M. (2011): Advances in metal-induced oxidative stress and human disease. Toxicology 283(2–3): 65 – 87. DOI: 10.1016/j.tox.2011.03.001JomovaKValkoM2011Advances in metal-induced oxidative stress and human diseaseToxicology2832–36587DOI:10.1016/j.tox.2011.03.00121414382Open DOISearch in Google Scholar

Kutalek, R., Wewalka, G., Gundacker, C., Auer, H., Wilson, J., Haluza, D., Huhulescu, S., Hillier, S., Sager, M., Prinz, A. (2010): Geophagy and potential health implications: geohelminths, microbes and heavy metals. Trans. R. Soc. Trop. Med. Hyg. 104(12): 787 – 795. DOI: 10.1016/j.trstmh.2010.09.002KutalekRWewalkaGGundackerCAuerHWilsonJHaluzaDHuhulescuSHillierSSagerMPrinzA2010Geophagy and potential health implications: geohelminths, microbes and heavy metalsTrans. R. Soc. Trop. Med. Hyg10412787795DOI:10.1016/j.trstmh.2010.09.00220889178Open DOISearch in Google Scholar

Lafferty, K. D., Kuris, A. M. (1999): How environmental stress affects the impacts of parasites. Limnol. Oceanogr. 44(3, part2): 925 – 931LaffertyKDKurisAM1999How environmental stress affects the impacts of parasitesLimnol. Oceanogr443, part292593110.4319/lo.1999.44.3_part_2.0925Search in Google Scholar

Lewis, R., Behnke, J. M., Stafford, P., Holland, C. V. (2006) The development of a mouse model to explore resistance and susceptibility to early Ascaris suum infection. Parasitology 132(2): 289 – 300. DOI: 10.1017/S0031182005008978.LewisRBehnkeJMStaffordPHollandCV2006The development of a mouse model to explore resistance and susceptibility to early Ascaris suum infectionParasitology1322289300DOI:10.1017/S003118200500897816209722Open DOISearch in Google Scholar

Lewis, R., Behnke, J. M., Cassidy, J. P., Stafford, P., Murray, N., Holland, C. V. (2007): The migration of Ascaris suum larvae, and the associated pulmonary inflammatory response in susceptible C57BL/6j and resistant CBA/Ca mice. Parasitology 134(9): 1301 – 1314. DOI: 10.1017/S0031182007002582.LewisRBehnkeJMCassidyJPStaffordPMurrayNHollandCV2007The migration of Ascaris suum larvae, and the associated pulmonary inflammatory response in susceptible C57BL/6j and resistant CBA/Ca miceParasitology134913011314DOI:10.1017/S003118200700258217381887Open DOISearch in Google Scholar

Marth, E., Barth, S., Jelovcan, S. (2000): Influence of cadmium on the immune system. Description of stimulating reactions. Cent. Eur. J. Public Health, 8(1): 40 – 44MarthEBarthSJelovcanS2000Influence of cadmium on the immune system. Description of stimulating reactionsCent. Eur. J. Public Health814044Search in Google Scholar

Mulcahy, G., O’Neill, S., Fanning, J., Mccarthy, E., Sekiya, M. (2005): Tissue migration by parasitic helminths - an immunoevasive strategy? Trends Parasitol., 21(6): 273 – 277. DOI: 10.1016/j. pt.2005.04.003MulcahyGO’NeillSFanningJMccarthyESekiyaM2005Tissue migration by parasitic helminths - an immunoevasive strategy?Trends Parasitol.216273277DOI:10.1016/j. pt.2005.04.003Open DOISearch in Google Scholar

Ngui, R., Lim, Y.A., Chong Kin, L., Sek Chuen, C., Jaffar, S. (2012): Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West Malaysia. PLoS Negl. Trop. Dis., 6(3): e1550. DOI: 10.1371/journal.pntd.0001550.NguiRLimYAChong KinLSek ChuenCJaffarS2012Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West MalaysiaPLoS Negl. Trop. Dis.63e1550DOI:10.1371/journal.pntd.0001550329580622413027Open DOISearch in Google Scholar

Pollard, K.M., Kono, D. H. (2013): Requirements for innate immune pathways in environmentally induced autoimmunity. BMC Med., 11(4): 100. DOI: 10.1186/1741-7015-11-100.PollardKMKonoDH2013Requirements for innate immune pathways in environmentally induced autoimmunityBMC Med.114100DOI:10.1186/1741-7015-11-100361684523557436Open DOISearch in Google Scholar

Šnábel, V., Taira, K., Cavallero, S., D'amelio, S., Rudohradská, P., Saitoh, Y. (2012): Genetic structure of Ascaris roundworm in Japan and patterns of its geographical variation. Jpn. J. Infect. Dis., 65(2): 179 – 183ŠnábelVTairaKCavalleroSD'amelioSRudohradskáPSaitohY2012Genetic structure of Ascaris roundworm in Japan and patterns of its geographical variationJpn. J. Infect. Dis.65217918310.7883/yoken.65.179Search in Google Scholar

Šoltys, J., Borošková, Z., Dvorožňáková, E. (1997): Effects of concurrently administered copper and mercury on phagocytic cell activity and antibody levels in guinea pigs with experimental ascariasis. J. Helminthol., 71(4): 339 – 444ŠoltysJBoroškováZDvorožňákováE1997Effects of concurrently administered copper and mercury on phagocytic cell activity and antibody levels in guinea pigs with experimental ascariasisJ. Helminthol.71433944410.1017/S0022149X00016163Search in Google Scholar

Swiergosz-Kowalewska, R. (2001): Cadmium distribution and toxicity in tissues of small rodents. Microsc. Res. Tech., 55(3): 208 – 222. DOI: 10.1002/jemt.1171Swiergosz-KowalewskaR2001Cadmium distribution and toxicity in tissues of small rodentsMicrosc. Res. Tech.553208222DOI:10.1002/jemt.117111747096Open DOISearch in Google Scholar

Tersago, K., De Coen, W., Scheirs J., Vermeulen, K., Blust, R., Van Bockstaele, D., Verhagen, R. (2004): Immunotoxicology in wood mice along a heavy metal pollution gradient. Environ. Pollut., 132(3): 385 – 394. DOI:10.1016/j.envpol.2004.05.029TersagoKDe CoenWScheirsJVermeulenKBlustRVan BockstaeleDVerhagenR2004Immunotoxicology in wood mice along a heavy metal pollution gradientEnviron. Pollut.1323385394DOI:10.1016/j.envpol.2004.05.02915325454Open DOISearch in Google Scholar

Turner, J.D., Faulkner, H., Kamgno, J., Cormont, F., Van Snick, J., Else, K.J., Grencis, R.K., Behnke, J.M., Boussinesq, M., Bradley, J. E. (2003): Th2 cytokines are associated with reduced worm burdens in a human intestinal helminth infection. J. Infect. Dis., 188(11): 1768 – 1775. DOI: 10.1086/379370TurnerJDFaulknerHKamgnoJCormontFVan SnickJElseKJGrencisRKBehnkeJMBoussinesqMBradleyJE2003Th2 cytokines are associated with reduced worm burdens in a human intestinal helminth infectionJ. Infect. Dis.1881117681775DOI:10.1086/37937014639550Open DOISearch in Google Scholar

Valko, M., Morris, H., Cronin, M. T. (2005): Metals, toxicity and oxidative stress. Curr. Med. Chem., 12(10): 1161 – 1208. DOI: 10.2174/0929867053764635ValkoMMorrisHCroninMT2005Metals, toxicity and oxidative stressCurr. Med. Chem.121011611208DOI:10.2174/092986705376463515892631Open DOISearch in Google Scholar

eISSN:
1336-9083
ISSN:
0440-6605
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Life Sciences, Zoology, Ecology, other, Medicine, Clinical Medicine, Microbiology, Virology and Infection Epidemiology