<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_fco-2015-0027_s_006_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Aim</h3><p>This trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid Cancer patients or not.</p></sec><sec id="j_fco-2015-0027_s_007_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Methods</h3><p>this study is a retrospective study of intermediate-risk papillary thyroid cancer patients that were treated with or without post operative RAI from 1st January 2002 till 1st January 2012. Overall survival (OS) and multivariate regression analyses were measured for all patients.</p></sec><sec id="j_fco-2015-0027_s_008_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Results</h3><p>100 patients were included in this trial : 70 patients received postoperative RAI and 30 patients did not. The mean follow-up time was 7.1 (4.8 -15.1 years), and a median survival time could not be estimated. Overall survival at 10 years was 96% in the RAI vs 93% in the group without RAI (P &lt; .001). RAI reduced risk of death by a 27% [hazard risk (HR) 0.73, confidence interval (CI) 0.64 - 0.84, P &lt; .001]. Older patient age, male gende, larger tumor size, multifocal tumors, lymph node metastases, aggressive histology, vascular invasion, positive surgical margin, minimal extrathyroidal extension and absence of postoperative RAI were accompanied by compromised OS (all P ≤ .001).</p></sec><sec id="j_fco-2015-0027_s_009_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Conclusion</h3><p>This representative study addresses the survival advantage of RAI for with intermediate risk PTC patients but conducting of large prospective randomized controlled trial is still warranted.</p></sec></abstract>

AimThis trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid Cancer patients or not.Methodsthis study is a retrospective study of intermediate-risk papillary thyroid cancer patients that were treated with or without post operative RAI from 1st January 2002 till 1st January 2012. Overall survival (OS) and multivariate regression analyses were measured for all patients.Results100 patients were included in this trial : 70 patients received postoperative RAI and 30 patients did not. The mean follow-up time was 7.1 (4.8 -15.1 years), and a median survival time could not be estimated. Overall survival at 10 years was 96% in the RAI vs 93% in the group without RAI (P < .001). RAI reduced risk of death by a 27% [hazard risk (HR) 0.73, confidence interval (CI) 0.64 - 0.84, P < .001]. Older patient age, male gende, larger tumor size, multifocal tumors, lymph node metastases, aggressive histology, vascular invasion, positive surgical margin, minimal extrathyroidal extension and absence of postoperative RAI were accompanied by compromised OS (all P ≤ .001).ConclusionThis representative study addresses the survival advantage of RAI for with intermediate risk PTC patients but conducting of large prospective randomized controlled trial is still warranted.

Is postoperative radioactive iodine associated with a survival advantage among…

Forum of Clinical Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

AimThis trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid...

	HR (95% Cl)	P Value
Age
< 45	1.00
≥ 45	1.36(0.94-1.92)	<0.001

Gender
Male	0.73(0.65-0.82)	<0.001
Female	1.00

Tumor size
T1	1.00	<0.001
T2	0.62(0.49-0.78)	<0.001
T3	0.74(0.56-0.97)

lymph nodes
N0	1.00
N1	1.45(1.05-2.12)	<0.001

Multifocality
Yes	0.83(0.75-0.92)	<0.001
No	1.00

Aggressive histology
Yes	0.94(0.58-1.66)	<0.001
No	1.00

vascular invasion
Yes	0.98(0.68-1.56)	<0.001
No	1.00

Positive margins
Yes	1.55(1.15-2.22)	<0.001
No	1.00

Extrathyroidal extension
Yes	0.62(0.49-0.78)	<0.001
No	1.00

RAI use
No	1.00
Yes	0.72(0.59-0.88)	<0.001

Characteristics	NO RAI		RAI		P
	%	n	%	n	Value
Age					<0.001
< 45	17	56.7	40	57.1%
≥ 45	13	43.3	30	42.9%

Gender					<0.001
Female	21	70	50	71.4%
Male	9	30	20	28.6%

Tumor size					<0.001
T1	18	60	10	14.2%
T2	6	20	20	28.7%
T3	6	20	40	57.1%

lymph nodes					<0.001
NO	22	73.3	10	14.2%
N1<1cm	8	26.7	10	14.2%
1:<2cm	0	0	20	28.7%
2:<3	0	0	30	42.9%

Multifocality					<0.001
Yes	10	33.3	36	49.1%
No	20	66.6	34	51.9%

Aggressive histology					<0.001
Yes	4	13.3	20	28.7%
No	26	86.7	50	71.3%

vascular invasion					<0.001
Yes	4	13.3	15	21.4%
No	26	86.7	55	78.6%

Positive margins					<0.001
Yes	5	16.7	15	21.4%
No	25	83.3	55	78.6%

Extrathyroidal extension					<0.001
Yes	4	13.3	15	21,4%
No	26	86,7	55	78.6%

Is postoperative radioactive iodine associated with a survival advantage among…

Published Online: Jun 30, 2017

Page range: 23 - 27

Received: Apr 11, 2017

Accepted: Aug 24, 2017

DOI: https://doi.org/10.1515/fco-2015-0027

Keywords
Postoperative radioactive iodine, intermediate-risk Papillary Thyroid Cancer

© 2017 Rasha Hamdy Hamed

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 1

Multivariate analysis of 100 patients with intermediate-risk papillary thyroid carcinoma.

Characteristics of Patients and Tumors.

Is postoperative radioactive iodine associated with a survival advantage among…

Published Online: Jun 30, 2017

Page range: 23 - 27

Received: Apr 11, 2017

Accepted: Aug 24, 2017

DOI: https://doi.org/10.1515/fco-2015-0027

KeywordsPostoperative radioactive iodine, intermediate-risk Papillary Thyroid Cancer

© 2017 Rasha Hamdy Hamed

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 1

Multivariate analysis of 100 patients with intermediate-risk papillary thyroid carcinoma.

Characteristics of Patients and Tumors.

Keywords
Postoperative radioactive iodine, intermediate-risk Papillary Thyroid Cancer