<abstract xmlns="http://www.w3.org/1999/xhtml"> Objective. The aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the inflammation and autoimmunity.Methods. This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient files. Serum irisin levels were measured by ELISA kit.Results. The median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p&lt;0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p&lt;0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels.Conclusion. In patients with T1DM, which chronic inflammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. Th is may suggest that factors such as inflammation and autoimmunity can be effective in the synthesis of irisin.</abstract>

Objective. The aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the inflammation and autoimmunity.Methods. This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient files. Serum irisin levels were measured by ELISA kit.Results. The median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels.Conclusion. In patients with T1DM, which chronic inflammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. Th is may suggest that factors such as inflammation and autoimmunity can be effective in the synthesis of irisin.

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ankara Numune Training and Research Hospital, Department of Internal Medicine, Ankara,

Turkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara,

Ankara Numune Training and Research Hospital, Department of Biochemistry, Ankara,

Ankara Numune Training and Research Hospital, Department of Biochemistry, Ankara, Turkey

Hitit University School of Medicine, Department of Endocrinology and Metabolism, Çorum,

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Factors associated with increased irisin levels in the type 1 diabetes mellitus"}

Objective. The aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of...

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Published Online: Feb 17, 2017

Page range: 1 - 7

DOI: https://doi.org/10.1515/enr-2017-0001

Keywords
IAnti glutamic acid decarboxylase, fibronectin type III domain containing 5, HbA1c, hyperglycemia, PGC1α

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Published Online: Feb 17, 2017

Page range: 1 - 7

DOI: https://doi.org/10.1515/enr-2017-0001

KeywordsIAnti glutamic acid decarboxylase, fibronectin type III domain containing 5, HbA1c, hyperglycemia, PGC1α

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
IAnti glutamic acid decarboxylase, fibronectin type III domain containing 5, HbA1c, hyperglycemia, PGC1α