Defining Metabolic Syndrome: Which Kind of Causality, if any, is Required?

Aguilar-Salinas, C.A.; Rojas, R.; Gómez-Pérez, F.J.; Mehta, R.; Franco, A.; Olaiz, G.; and Rull, J.A. 2005. The metabolic syndrome: a concept hard to define Archives of Medical Research 36(3):223–31.10.1016/j.arcmed.2004.12.003Search in Google Scholar

Alberti, K.G. 2005. Introduction to the metabolic syndrome. European Heart Journal Supplements 7 (D): D3–D5.10.1093/eurheartj/sui021Open DOISearch in Google Scholar

Alberti, K. G.; and Zimmet, P. F. 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetic Medicine 15(7): 539–53.10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-SOpen DOISearch in Google Scholar

Alberti, K.G.; Eckel, P.; Grundy, S.M. et al. 2009. Harmonizing the metabolic syndrome. A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention, National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640–5.Search in Google Scholar

Alberti, K. G. M.; Zimmet, P.; Shaw, J. and IDF Epidemiology Task Force Consensus Group. 2005. The metabolic syndrome—a new worldwide definition. The Lancet 366(9491): 1059–62.10.1016/S0140-6736(05)67402-8Search in Google Scholar

ATP III. 2001. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285(19): 2486–7.10.1001/jama.285.19.2486Search in Google Scholar

Balkau, B.; and Charles, M. A. 1999. Comment on the provisional report from the WHO consultation. Diabetic Medicine 16(5): 442–3.10.1046/j.1464-5491.1999.00059.xOpen DOISearch in Google Scholar

Boyd, R. 1991. Anti-foundationalism and the enthusiasm for natural kinds. Philosophical Studies 61(1–2): 127–48.10.1007/BF00385837Search in Google Scholar

Boyd, R. 1999. Homeostasis, species, and higher taxa. In Species: New Interdisciplinary Studies, ed. by R. Wilson. Cambridge, MA: MIT Press, 141–85.Search in Google Scholar

Campaner, R. 2011. Understanding mechanisms in the health sciences. Theoretical Medicine and Bioethics. 32 (1): 5–17.10.1007/s11017-010-9166-5Open DOISearch in Google Scholar

Craver, C. F. 2009. Mechanisms and natural kinds. Philosophical Psychology 22(5): 575–94.10.1080/09515080903238930Open DOISearch in Google Scholar

Enzi, G.; Busetto, L.; Inelmen, E. M.; Coin, A.; and Sergi, G. 2003. Historical perspective: visceral obesity and related comorbidity in Joannes Baptista Morgagni’s ‘De Sedibus et Causis Morborum per Anatomen Indagata’. International Journal of Obesity 27(4): 534–5.10.1038/sj.ijo.0802268Open DOISearch in Google Scholar

Eschwège, E. 2005. Metabolic syndrome: which definition(s) for which objective(s)?]. Annales d’Endocrinologie 66(2 Pt 2):1S32–44.10.1016/S0003-4266(05)81732-9Search in Google Scholar

Federspil, G.; Nisoli, E.; and Vettor, R. 2006. A critical reflection on the definition of metabolic syndrome. Pharmacological Research 53: 449–56.10.1016/j.phrs.2006.03.008Search in Google Scholar

Fujioka, S.; Matsuzawa, Y.; Tokunaga, K.; and Tarui, S. 1987. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36: 54–9.10.1016/0026-0495(87)90063-1Search in Google Scholar

Grundy, S. M.; Cleeman, J. I.; et al. 2006. Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Current Opinion in Cardiology 21: 1–6.Search in Google Scholar

Haller, H.; and Hanefeld, M. 1975. Synoptische Betrachtung Metabolischer Risikofaktoren. In Lipidstoffwechselstörungen, ed. by H. Haller, M. Hanefeld and W. Jaross. Jena: Gustav Fischer Verlag, 254–64.Search in Google Scholar

Hitzenberger, K.; and Richter-Quittner, M. 1921. Ein Beitrag zum Stoffwechsel bei der vasculären Hypertonie. Wiener Archive für Innere Medizin 2: 189–216.Search in Google Scholar

IDF (International Diabetes Federation). 2005. The IDF Consensus Worldwide Definition of the Metabolic Syndrome. Available at: www.idf.org/metabolic-syndrome.Search in Google Scholar

Jørgensen, M.E.; and Borch-Johnsen, K. 2004. The metabolic syndrome—is one global definition possible? Diabetic Medicine 21(10):1064–5.10.1111/j.1464-5491.2004.01400.xSearch in Google Scholar

Kahn, R. 2006. The metabolic syndrome (emperor) wears no clothes. Diabetes Care 29(7): 1693–6.10.2337/dc06-0671Search in Google Scholar

Kahn, R.; Buse, J.; Ferrannini, E.; and Stern, M. 2005. The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28(9): 2289–304.10.2337/diacare.28.9.2289Open DOISearch in Google Scholar

Kendler, K. S.; Zachar, P.; and Craver, C. 2011. What kinds of things are psychiatric disorders? Psychological Medicine 41(06): 1143–50.10.1017/S0033291710001844Open DOISearch in Google Scholar

Kincaid, H. 2008. Do we need theory to study disease? Lessons from cancer research and their implications for mental illness. Perspectives in Biology and Medicine 51(3): 367–78.10.1353/pbm.0.0019Open DOISearch in Google Scholar

Kincaid, H. 2011. Causal modelling, mechanisms, and probability in epidemiology. In Causality in the Sciences, ed. Phyllis McKay Illari, Federica Russo and Ion Williamson. Oxford: Oxford University Press: 70–90.Search in Google Scholar

Kincaid, H. 2012. Mechanisms, causal modeling, and the limitations of traditional regression. In The Oxford Handbook of Philosophy of Social Science, ed. Harold Kincaid. Oxford: Oxford University Press: 46–64.Search in Google Scholar

Kissebah, A.H.; Vydelingum, N.; Murray, R.; Evans, D. J.; Kalkhoff, R. K.; and Adams, P. W. 1982. Relation of body fat distribution to metabolic complications of obesity. The Journal of Clinical Endocrinology and Metabolism 54 (2): 254–60.10.1210/jcem-54-2-254Open DOISearch in Google Scholar

Kitano, H.; Oda, K.; Kimura, T.; Matsuoka, Y.; Csete, M.; Doyle, J.; and Muramatsu, M. 2004. Metabolic syndrome and robustness tradeoffs. Diabetes 53 (suppl 3): S6–S15.10.2337/diabetes.53.suppl_3.S6Search in Google Scholar

Kraja, A. T.; Province, M. A.; Huang, P.; Jarvis, J. P.; Rice, T.; Cheverud, J. M.; and Rao, D. C. 2008. Trends in metabolic syndrome and gene networks in human and rodent models. Endocrine, Metabolic and Immune Disorders-Drug Targets 8(3): 198–207.10.2174/187153008785700145Search in Google Scholar

Kylin, E. 1921. Hypertonie und Zuckerkrankenheit. Zentralblatt für innere Medizin 42: 873–7.Search in Google Scholar

Kylin, E. 1923. Studien über das Hypertonie-Hyperglykämie-Hyperurikämie Syndrom. Zentralblatt für innere Medizin 44: 105–27.Search in Google Scholar

Lam, D. W.; and LeRoith, D. 2015. Metabolic syndrome. In Endotext [Internet]. Ed. by L.J De De Groot, P. Beck-Peccoz, G. Chrousos et al. http://www.ncbi.nlm.nih.gov/pubmed/25905173.Search in Google Scholar

Leśniak, W.; and Kolasińska-Kloch, W. 2003. Do syndromes X, cardiac and metabolic, have any similar characteristics?. Folia Medica Cracoviensia 44(1–2): 59–69.Search in Google Scholar

Liberopoulos, E.N.; and Elisaf, M.S. 2005. Diagnosis of the metabolic syndrome: which definition should we use? The Hellenic Journal of Cardiology 46(4): 258–62.Search in Google Scholar

Lim, H.S.; Patel, J.V.; Lip, G.Y. 2004. Metabolic syndrome: a definition in progress. Circulation 110(4):e35; author reply e35.10.1161/01.CIR.0000139383.19636.D6Search in Google Scholar

Marañon, G. 1922. Über Hypertonie und Zuckerkrankenheit. Zentralblatt für Innere Medizin 43: 169–76.Search in Google Scholar

Mitka, M. 2005. Does the metabolic syndrome really exist? JAMA 294: 2010–3.10.1001/jama.294.16.2010Search in Google Scholar

Ninomiya, J.K.; L’Italien, G.; Criqui, M.H.; Whyte, J.L.; Gamst, A.; Chen, R. 2004. Association of the metabolic syndrome with history of myocardial infarction and stroke in the third National Health and Nutrition Examination Survey. Circulation 109: 42– 6.10.1161/01.CIR.0000108926.04022.0CSearch in Google Scholar

Oda, E. 2012. Metabolic syndrome: its history, mechanisms, and limitations. Acta Diabetologica 49(2): 89–95.10.1007/s00592-011-0309-6Open DOISearch in Google Scholar

Pearl, J. 2000. Causality: Models, Reasoning, and Inference. Cambridge: Cambridge University Press. 2^nd ed. 2010.Search in Google Scholar

Real, J.T.; and Carmena, R. 2005. Relevance of metabolic syndrome and its definition depending on the criteria employed. Medicina Clinica 124(10): 376–8.10.1157/13072572Search in Google Scholar

Reaven, G. M. 1988. Role of insulin resistance in human disease. Diabetes 37: 1595–607.10.2337/diab.37.12.1595Search in Google Scholar

Reaven, G M. 2004. The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinology and Metabolism Clinics of North America 33(2): 283–303.10.1016/j.ecl.2004.03.002Open DOISearch in Google Scholar

Reaven, G. M. 2005. The metabolic syndrome: requiescat in pace. Clinical Chemistry 51(6): 931–8.1574630010.1373/clinchem.2005.048611Search in Google Scholar

Reaven, G. M. 2006. The metabolic syndrome: is this diagnosis necessary? The American Journal of Clinical Nutrition 83(6): 1237–47.10.1093/ajcn/83.6.1237Open DOISearch in Google Scholar

Reaven, G. M. 2011. The metabolic syndrome: time to get off the merry-go-round? Journal of Internal Medicine 269 (2): 127–36.10.1111/j.1365-2796.2010.02325.xSearch in Google Scholar

Rosas Peralta, M. 2005. Definition of metabolic syndrome: Tower of Babel. Archivos de cardiología de México 75(2): 230–3.Search in Google Scholar

Shahar, E. 2010. Metabolic syndrome? A critical look from the viewpoints of causal diagrams and statistics. Journal of Cardiovascular Medicine 11(10): 772–9.10.2459/JCM.0b013e32833b9088Search in Google Scholar

Spirtes, P.; Glymour, C. N.; and Scheines, R. 1993. Causation, Prediction, and Search. Lecture Notes in Statistics. 2^nd ed. Cambridge: Cambridge University Press, 2009.10.1007/978-1-4612-2748-9_8Open DOISearch in Google Scholar

Vague, J. 1947. La différenciation sexuelle: facteur déterminant des formes de l’obesité. Presse Medicale 30: 339–40.Search in Google Scholar

Zimmermann, J. G. 1763. Von der Erfahrung in der Arzneykunst. 2 Bde. Zürich: bey Heidegger und Compagnie.Search in Google Scholar