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Analysis of Nicotine and Nicotine-Related Compounds in Electronic Cigarette Liquids and Aerosols by Liquid Chromatography-Tandem Mass Spectrometry


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1. Brown, C.J. and J.M. Cheng: Electronic Cigarettes: Product Characterization and Design Considerations; Tob. Control 23 (2014) ii4–ii10. DOI: 10.1136/tobaccocontrol-2013-05147610.1136/tobaccocontrol-2013-051476399527124732162Open DOISearch in Google Scholar

2. Medana, C., R. Aigotti, C. Sala, F. Dal Bello, V. Santoro, D. Gastaldi, and C. Baiocchi: Analysis of Nicotine Alkaloids and Impurities in Liquids for E-Cigarettes by LC-MS, GC-MS, and ICP-MS; Spectroscopy 14 (2016) 20–28.Search in Google Scholar

3. Hukkanen, J., P. Jacob III, and N.L. Benowitz: Metabolism and Disposition Kinetics of Nicotine; Pharmacol. Rev. 57 (2005) 79–115. DOI: 10.1124/pr.57.1.310.1124/pr.57.1.315734728Open DOISearch in Google Scholar

4. Etter, J.-F., E. Zäther, and S. Svensson: Analysis of Refill Liquids for Electronic Cigarettes; Addiction 108 (2013) 1671–1679. DOI: 10.1111/add.1223510.1111/add.1223523701634Open DOISearch in Google Scholar

5. Hoffman, D. and S.S. Hecht: Nicotine-Derived N-Nitrosamines and Tobacco-Related Cancer: Current Status and Future Directions; Cancer Res. 45 (1985) 934–944.Search in Google Scholar

6. Sheng, L.Q., L. Ding, H.W. Tong, G.P. Yong, X.Z. Zhou, and S.M. Liu: Determination of Nicotine-Related Alkaloids in Tobacco and Cigarette Smoke by GC-FID; Chromatographia 62 (2005) 63–68. DOI: 10.1365/s10337-005-0567-y10.1365/s10337-005-0567-yOpen DOISearch in Google Scholar

7. Cai, J., B. Liu, P. Lin, and Q. Su: Fast Analysis of Nicotine Related Alkaloids in Tobacco and Cigarette Smoke by Megabore Capillary Gas Chromatography; J. Chromatogr. A 1017 (2003) 187–193.10.1016/j.chroma.2003.07.003Search in Google Scholar

8. Yang, S.S., Smetena, S.I., and C. Huang: Determination of Tobacco Alkaloids by Gas Chromatography with Nitrogen–Phosphorus Detection; Anal. Bioanal. Chem. 373 (2002) 839–843. DOI: 10.1007/s00216-002-1380-110.1007/s00216-002-1380-112194047Search in Google Scholar

9. Lisko, J.G., S.B. Stanfill, B.W. Duncan, and C.H. Watson: Application of GC-MS/MS for the Analysis of Tobacco Alkaloids in Cigarette Filler and Various Tobacco Species; Anal. Chem. 85 (2013) 3380–3384. DOI: 10.1021/ac400077e10.1021/ac400077e457352523394466Open DOISearch in Google Scholar

10. Flora, J., W.N. Meruva, C.B. Huang, C.T. Wilkinson, R. Ballentine, D.C. Smith, M.S. Werley, and W.J. McKinney: Characterization of Potential Impurities and Degradation Products in Electronic Cigarette Formulations and Aerosols; Regul. Toxicol. Pharmacol. 74 (2016) 1–11. DOI: 10.1016/j.yrtph.2015.11.00910.1016/j.yrtph.2015.11.00926617410Search in Google Scholar

11. Trehy, M.L., W. Ye, M.E. Hadwiger, T.W. Moore, J.F. Allgire, J.T. Woodruff, S.S. Ahadi, J.C. Black, and B.J. Westenberger: Analysis of Electronic Cigarette Cartridges, Refill Solutions, and Smoke for Nicotine and Nicotine Related Impurities; J. Liq. Chromatogr. Relat. Technol. 34 (2011) 1442–1458. DOI: 10.1080/10826076.2011.57221310.1080/10826076.2011.572213Open DOISearch in Google Scholar

12. Tierney, P.A., C.D. Karpinski, J.E. Brown, W. Luo, and J.F. Pankow: Flavor Chemicals in Electronic Cigarette Fluids; Tob. Control. (2015) 1–6. DOI: 10.1136/tobaccocontrol-2014-05217510.1136/tobaccocontrol-2014-052175485354125877377Open DOISearch in Google Scholar

13. Velisek, J.: The Chemistry of Food; John Wiley & Sons, Hoboken, NJ, USA, 2013.Search in Google Scholar

14. Gorrod, J.W. and M.-C. Tsai: Nicotine and the Tobacco Alkaloids; in: Molecules of Death; edited by R.H. Waring, G.B. Steventon, and S.C. Mitchell, Imperial College Press, London, UK, 2002, pp. 163–181.10.1142/9781860944536_0009Search in Google Scholar

15. Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA): CORESTA Recommended Method No. 81: Routine Analytical Machine for E-Cigarette Aerosol Generation and Collection — Definitions and Standard Conditions; 2015, 1–6. Available at: https://www.coresta.org/sites/default/files/technical_documents/main/CRM_81.pdf (accessed July 2017)Search in Google Scholar

16. Gorrod, J.W. and P. Jacob III (eds.): Analytical Determination of Nicotine and Related Compounds and Their Metabolites; Elsevier, Amsterdam, The Netherlands, 1999, pp. 76–77.Search in Google Scholar

17. Wang, P., W. Chen, J. Liao, T. Matsuo, K. Ito, J. Fowles, D. Shusterman, M. Mendell, and K. Kumagai: A Device-Independent Evaluation of Carbonyl Emissions from Heated Electronic Cigarette Solvents; PLOS ONE, 12 (2017) e0169811. DOI: 10.1371/journal.pone.016981110.1371/journal.pone.0169811522672728076380Search in Google Scholar

18. Famele, M., J. Palmisani, C. Ferranti, C. Abenavoli, L. Palleschi, R. Mancinelli, R.M. Fidente, G.D. Gennaro, and R. Draisci: Liquid Chromatography with Tandem Mass Spectrometry Method for the Determination of Nicotine and Minor Tobacco Alkaloids in Electronic Cigarette Refill Liquids and Second-Hand Generated Aerosols; J. Sep. Sci. 40 (2017) 1049–1056. DOI: 10.1002/jssc.20160107610.1002/jssc.20160107628012240Open DOISearch in Google Scholar

19. International Council for Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH): ICH Harmonized Tripartite Guideline — Impurities in New Drug Products — Q3B (R2); ICH, Geneva, Switzerland, 2006. Available at: http://www.ich.org/products/guidelines/quality/qualitysingle/article/impurities-in-new-drug-products.html. (accessed July 2017)Search in Google Scholar

20. United States Pharmacopeia and the National Formulary: USP 38-NF 33; The United States Pharmacopeia Convention Inc., Rockville, MD, USA, 2015, pp. 1063–1066.Search in Google Scholar

21. Farsalinos, K.E., I.G. Gillman, S.S. Hecht, R. Polosa, and J. Thornburg: Analytical Assessment of E-Cigarettes: From Contents to Chemical and Particle Exposure Profiles; Elsevier, Amsterdam, The Netherlands, 2016, pp. 9–30.Search in Google Scholar

22. Miller, J. and J.W. Flora: Effect of Puff Duration and Puff Volume on E-Cigarette Aerosol Collection; 69th Tobacco Science Research Conference, Naples, FL, USA, September 2015. Program Booklet and Abstracts, pp. 58–59. Available at: https://www.coresta.org/sites/default/files/events/69th-TSRC-Prog-Abstracts_2015.pdf (accessed July, 2017)Search in Google Scholar

23. Geiss, O., I. Bianchi, and J. Barrero-Moreno: Correlation of Volatile Carbonyl Yields Emitted by E-Cigarettes With the Temperature of the Heating Coil and the Perceived Sensorial Quality of the Generated Vapors; Int. J. Hyg. Environ. Health 219 (2016) 268–277. DOI: 10.1016/j.ijheh.2016.01.00410.1016/j.ijheh.2016.01.00426847410Open DOISearch in Google Scholar

24. Rodgman, A. and T.A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke (second edition); CRC Press, Boca Raton, FL, USA, 2016, pp. 925–926.10.1201/b13973Search in Google Scholar

25. Flora, J.W., C.T. Wilkinson, K.M. Sink, D.L. McKinney, and J.H. Miller: Nicotine-Related Impurities in E-Cigarette Cartridges and Refill E-liquids; J. Liq. Chromatogr. Relat. Technol. 39 (2016) 821–829. DOI: 10.1080/10826076.2016.126650010.1080/10826076.2016.1266500Open DOISearch in Google Scholar

26. US Food and Drug Administration (FDA): Guidance for Industry. Drug Stability Guidelines; Available at: https://www.fda.gov/downloads/animalveterinary/guidancecomplianceenforcement/guidanceforindustry/ucm051556.pdf (accessed July 2017)Search in Google Scholar

27. Bertholon, J.F., M.H. Becquemin, I. Annesi-Maesano, and B. Dautzenberg: Electronic Cigarettes: A Short Review; Respiration 86 (2013) 433–438. DOI: 10.1159/00035325310.1159/00035325324080743Open DOISearch in Google Scholar

28. Choi, K., L. Fabian, N. Mottey, A. Corbett, and J. Forster: Young Adults’ Favorable Perceptions of Snus, Dissolvable Tobacco Products, and Electronic Cigarettes: Findings from a Focus Group Study; Am. J. Public Health 102 (2012) 2088–2093. DOI: 10.2105/AJPH.2011.30052510.2105/AJPH.2011.300525346975922813086Open DOISearch in Google Scholar

29. Wang, L., Y. Zhan, Q. Li, D. Zeng, S.J. Leischow, and J. Okamoto: An Examination of Electronic Cigarette Content on Social Media: Analysis of E-Cigarette Flavor Content on Reddit; Int. J. Environ. Res. Public Health 12 (11) (2015) 14916–35. DOI: 10.3390/ijerph12111491610.3390/ijerph121114916466168826610541Open DOISearch in Google Scholar

30. Marcilla, A., M.I. Beltrán, A. Gomez-Siurana, I. Martinez, and D. Berenguer: Study of the Effect of Different Catalysts in the Decomposition of Nicotine; 69th Tobacco Science Research Conference, Naples, FL, USA, September 2015. Program Booklet and Abstracts, p. 57, Poster, No. 67. Available at: https://www.coresta.org/sites/default/files/events/69th-TSRC-Prog-Abstracts_2015.pdf (accessed July 2017)Search in Google Scholar

31. Schmeltz, I., A. Wenger, D. Hoffmann, and T.C. Tso: Chemical Studies on Tobacco Smoke. 63. On the Fate of Nicotine during Pyrolysis and in a Burning Cigarette; J. Agric. Food Chem. 27 (1978) 602–608. DOI: 10.1021/jf60223a04410.1021/jf60223a044Open DOISearch in Google Scholar

32. Hădărugă, D.I., N.G. Hădărugă, G. Butnaru, C. Tatu, and A. Gruia: Bioactive Microparticles (10): Thermal and Oxidative Stability of Nicotine and its Complex with β-cyclodextrin; J. Incl. Phenom. Macrocycl. Chem. 68 (2010) 155–164. DOI: 10.1007/s10847-010-9761-010.1007/s10847-010-9761-0Search in Google Scholar

33. Kisaki, T., S. Maeda, A. Koiwai, Y. Mikami, T. Sasaki, and H. Matsushita: Transformation of Tobacco Alkaloids; Beitr. Tabakforsch. Int. 9 (1978) 308–316. DOI: 10.2478/cttr-2013-046110.2478/cttr-2013-0461Open DOISearch in Google Scholar

34. Linnell, R.H.: The Oxidation of Nicotine. I. Kinetics of the Liquid Phase Reaction near Room Temperature; Tob. Sci. 4 (1960) 89–91.Search in Google Scholar

35. Lisko, J.G., H. Tran, S. B. Stanfill, B.C. Blount, and C.H. Watson: Chemical Composition and Evaluation of Nicotine, Tobacco Alkaloids, pH and Selected Flavors in E-Cigarette Cartridges and Refill Solutions; Nicotine Tob. Res. 17 (10) (2015) 1270–1278. DOI: 10.1093/ntr/ntu27910.1093/ntr/ntu279457395525636907Search in Google Scholar

eISSN:
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Language:
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Journal Subjects:
General Interest, Life Sciences, other, Physics