<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Current treatment and prevention of chronic rhinitis (CR) and chronic tonsillitis (CT) highlights the need for clinical trials in the respective laboratory model, of better options, including new medicaments. Therefore, to understand CR and CT via the laboratory model, the chronic pro-inflammatory process was simulated in laboratory animals (“Chinchilla” rabbits) using the reference <italic>Staphylococcus aureus strain 209P</italic> (<italic>ATCC 6538-P</italic>). Initial sensitizing of the laboratory animals with the inactivated causative agent and subsequently infecting the required area with the reference-strain made it possible to work out a reproducible model of both chronic rhinitis and chronic tonsillitis. Adequacy of CR and CT development was confirmed by the results of microbiological and pathomorphological investigations. The proposed laboratory model can be used to solve theoretical and practical medical current issues, as well as pharmacological topical problems.</p></abstract>

Current treatment and prevention of chronic rhinitis (CR) and chronic tonsillitis (CT) highlights the need for clinical trials in the respective laboratory model, of better options, including new medicaments. Therefore, to understand CR and CT via the laboratory model, the chronic pro-inflammatory process was simulated in laboratory animals (“Chinchilla” rabbits) using the reference Staphylococcus aureus strain 209P (ATCC 6538-P). Initial sensitizing of the laboratory animals with the inactivated causative agent and subsequently infecting the required area with the reference-strain made it possible to work out a reproducible model of both chronic rhinitis and chronic tonsillitis. Adequacy of CR and CT development was confirmed by the results of microbiological and pathomorphological investigations. The proposed laboratory model can be used to solve theoretical and practical medical current issues, as well as pharmacological topical problems.

Chronic rhinitis and chronic tonsillitis of staphylococcal genesis in rabbits as laboratory animal model for experimental research

International NGO “UZCC” Clinic and State Institution “Prof. O.S. Kolomiichenko Institute of Otolaryngology of the National Academy of Medical Sciences of Ukraine”

State Institution “І.І. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine”

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Current treatment and prevention of chronic rhinitis (CR) and chronic tonsillitis (CT) highlights the need for clinical trials in the respective laboratory...

Chronic rhinitis and chronic tonsillitis of staphylococcal genesis in rabbits as laboratory animal model for experimental research

Published Online: Oct 29, 2018

Page range: 140 - 143

Received: Jan 10, 2018

Accepted: Mar 22, 2018

DOI: https://doi.org/10.1515/cipms-2018-0027

Keywords
laboratory model, chronic rhinitis, chronic tonsillitis

© 2018 Hans Manee et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Chronic rhinitis and chronic tonsillitis of staphylococcal genesis in rabbits as laboratory animal model for experimental research

Published Online: Oct 29, 2018

Page range: 140 - 143

Received: Jan 10, 2018

Accepted: Mar 22, 2018

DOI: https://doi.org/10.1515/cipms-2018-0027

Keywordslaboratory model, chronic rhinitis, chronic tonsillitis

© 2018 Hans Manee et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
laboratory model, chronic rhinitis, chronic tonsillitis