<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using tramadol hydrochloride (TRH) as the template, acryl amide (AA) and 2-hydroxy ethyl meth acrylate (2-HEMA) as monomers, divinyl benzene as a cross linker, and benzoyl peroxide as initiator, respectively. The same composition was used to prepare non-imprinted polymers (NIPs), but without the template (Tramadol hydrochloride). Different plasticizers were employed to prepare the membranes; tris (ethyl hexyl) phosphate (TEHP), tri Butyl phosphate (TBP), di-octyl phthalate (DOP) and nitrobenzene (NB) in PVC matrix. The electrode characteristics and properties were studied, including: slope, detection limit, life time and linearity range. The results of selectivity coefficient measurements using amino acids as interfering species showed no effect on tramadol electrode response. The prepared electrodes were intended for use in determining tramadol in pharmaceutical samples</p></abstract>

Four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using tramadol hydrochloride (TRH) as the template, acryl amide (AA) and 2-hydroxy ethyl meth acrylate (2-HEMA) as monomers, divinyl benzene as a cross linker, and benzoyl peroxide as initiator, respectively. The same composition was used to prepare non-imprinted polymers (NIPs), but without the template (Tramadol hydrochloride). Different plasticizers were employed to prepare the membranes; tris (ethyl hexyl) phosphate (TEHP), tri Butyl phosphate (TBP), di-octyl phthalate (DOP) and nitrobenzene (NB) in PVC matrix. The electrode characteristics and properties were studied, including: slope, detection limit, life time and linearity range. The results of selectivity coefficient measurements using amino acids as interfering species showed no effect on tramadol electrode response. The prepared electrodes were intended for use in determining tramadol in pharmaceutical samples

Synthesis and Characterization of Molecularly Imprinted Polymer for Tramadol Hcl Using Acryl Amide and 2-Hydroxyethyl Meth Acrylate as Monomers

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using tramadol hydrochloride (TRH) as the template,...

Synthesis and Characterization of Molecularly Imprinted Polymer for Tramadol Hcl Using Acryl Amide and 2-Hydroxyethyl Meth Acrylate as Monomers

Published Online: Jul 28, 2018

Page range: 81 - 88

Received: Dec 18, 2017

Accepted: Feb 15, 2018

DOI: https://doi.org/10.1515/cipms-2018-0016

Keywords
molecularly imprinted electrodes, tramadol hydrochloride, potentiometric method, 2-HEMA, AA monomers

© 2018 Yehya Kamal Al-Bayati, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Synthesis and Characterization of Molecularly Imprinted Polymer for Tramadol Hcl Using Acryl Amide and 2-Hydroxyethyl Meth Acrylate as Monomers

Published Online: Jul 28, 2018

Page range: 81 - 88

Received: Dec 18, 2017

Accepted: Feb 15, 2018

DOI: https://doi.org/10.1515/cipms-2018-0016

Keywordsmolecularly imprinted electrodes, tramadol hydrochloride, potentiometric method, 2-HEMA, AA monomers

© 2018 Yehya Kamal Al-Bayati, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
molecularly imprinted electrodes, tramadol hydrochloride, potentiometric method, 2-HEMA, AA monomers