<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease.</p></abstract>

The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease.

Ultrastructural changes in murine liver following HSV infection and stroke

O.O. Bogomolets National Medical University

Gromashevsky L.V. Institute of Epidemiology and Infection Diseases of NAMS of Ukraine

State Institution “D.F. Chebotarev Institute of Gerontology” of NAMS of Ukraine

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Ultrastructural changes in murine liver following HSV infection and stroke"}

The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied,...

Ultrastructural changes in murine liver following HSV infection and stroke

Published Online: Apr 11, 2018

Page range: 10 - 12

Received: Nov 07, 2017

Accepted: Dec 27, 2017

DOI: https://doi.org/10.1515/cipms-2018-0002

Keywords
liver, ultrastructure, herpes simplex virus type I, stroke

© 2018 Natalia Motorna et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Ultrastructural changes in murine liver following HSV infection and stroke

Published Online: Apr 11, 2018

Page range: 10 - 12

Received: Nov 07, 2017

Accepted: Dec 27, 2017

DOI: https://doi.org/10.1515/cipms-2018-0002

Keywordsliver, ultrastructure, herpes simplex virus type I, stroke

© 2018 Natalia Motorna et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
liver, ultrastructure, herpes simplex virus type I, stroke